UTERINE TUMOR RESEMBLING OVARIAN SEX CORD TUMOR; A RARE CASE REPORT WITH HISTOPATHOLOGY, IMMUNOHISTOCHEMICAL FINDINGS AND P53 EXPRESSION

Year 2024, Issue: 1, 29 - 36, 14.03.2024

Ebru Altındal Susem

Abstract

Uterine tumors resembling ovarian sex cord tumors, is a rare mesenchymal tumor of the uterus that displays similar histological features of sex cord tumors. The pathogenesis for this tumor, which was first described by Morehead and Bowman in 1945 and about 100 cases of which have been published so far, is still unknown (1). It is frequently seen in perimenopausal or menopausal women around the age of 45 (2). It can manifest itself with gynecological symptoms such as menorrhagia, postmenopausal bleeding, abdominal pain, or it can be detected incidentally with no symptoms (3). Although it behaves like benign tumors, its attitude is unpredictable due to publications reporting that it recurs and metastases and it can be considered as a low malignancy potential tumor (4,5,6). Therefore, bilateral salpingooferectomy and hysterectomy is the most reliable method in the treatment, except for the reproductive age where only tumor resection is performed (7).
Histopathologically, they show varying features such as glandular, macrofollicular, microfollicular, trabecular, tubular, cords, retiform, solid clusters, diffuse or mixed. Immunohistochemically, it displays a pattern of unknown origin due to its staining with epithelial, smooth muscle and sex cord markers. For this reason, it is among the miscellaneous mesenchymal tumors of the corpus uteri in the World Health Organization classification (8).
Here, I present a case of this rare tumor accompanied by histomorphological findings and immunohistochemical studies including P53. P53 marker study in uterine tumor resembling ovarian sex cord tumor has been reported in only four cases in the literature; three of them showed P53 marker positivity and one mentioned that it could be associated with recurrence or tumor progression (3,7,9). More studies need to be done in terms of prognostic or diagnostic value between uterine tumors resembling ovarian sex cord tumors and P53 marker. Our case showed overt expression with p53.

Keywords

OVARY, SEX CORD TUMOURS, UTERINE TUMOR RESEMBLING

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