Decreased Serum VEGF and TGF-Β1 Levels in Advanced Alzheimer's Patients; a preliminary study

Year 2024, Issue: 2, 55 - 65, 30.09.2024

Ender Kaya , Durmuş Ayan , Esma Özmen , Seyyid Mehmet Bulut , İsmail Sarı , Serpil Erşan

Abstract

Aim: This study aimed to investigate Vascular endothelial growth factor (VEGF) and Transforming growth factor beta 1(TGF-β1) levels in advanced Alzheimer's disease (AD).
Materials and Methods: A total of 60 participants were evaluated within the scope of the study. 30 of them constituted the patient group and 30 constituted the control group. VEGF and TGF-β1 levels in serum samples of the patient and control groups were measured by Enzyme-Linked Immunosorbent Assay (ELISA).
Results: In the AD group, serum VEGF levels were found to be statistically significantly lower than in the control group (1373.66±486.07 ng/L vs. 986.27±261.44 ng/L, p<0.001). TGFβ-1 levels were also found to be significantly decreased in the AH group compared to the control group (21.26±3.77 ng/ml vs. 24.63±2.73 ng/ml, p<0.001).
Conclusion: Our findings suggest that the decrease in VEGF and TGF-β1 levels in the AD group may be related to the disease. However, more comprehensive and large-scale studies are needed.

Keywords

Alzheimer disease, VEGF, TGF-β1

İleri Alzheimer Hastalarında Azalmış Serum VEGF ve TGF-Β1 Seviyeleri; bir ön çalışma

Abstract

Amaç: Bu araştırmada ileri evre Alzheimer hastalığında (AH) VEGF (Vasküler Endotelyal Büyüme Faktörü) ve TGF-β1 (Dönüştürücü Büyüme Faktörü-Beta 1) seviyelerinin incelenmesi amaçlanmıştır.
Gereç ve Yöntemler: Çalışma kapsamında toplam 60 katılımcı değerlendirilmiştir. Bunların 30'u hasta grubunu, 30'u ise kontrol grubunu oluşturmaktadır. Hasta ve kontrol grubuna ait serum örneklerinde VEGF ve TGF-β1 düzeyleri (ELISA) yöntemiyle ölçülmüştür.
Bulgular: AH grubunda, serum VEGF düzeyleri kontrol grubuna göre istatistiksel olarak anlamlı düzeyde düşük bulunmuştur (1373,66±486,07 ng/L'e karşılık 986,27±261,44 ng/L, p<0,001). TGFβ-1 düzeylerinin de AH grubunda kontrol grubuna göre önemli ölçüde azaldığı tespit edilmiştir (21,26±3,77 ng/ml'e karşılık 24,63±2,73 ng/ml, p<0,001).
Sonuç: Bulgularımız, AH grubunda VEGF ve TGF-β1 düzeylerindeki azalmanın hastalıkla ilişkili olabileceğini göstermektedir, ancak daha kapsamlı ve geniş katılımlı çalışmalara ihtiyaç olduğu düşünülmektedir.

Keywords

Alzheimer hastalığı, VEGF, TGF-β1

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