Review

Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review

Volume: 2 Number: 2 May 31, 2026
TR EN

Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review

Abstract

Sedation and analgesia management in intensive care units is one of the fundamental care processes that directly affects mechanical ventilation duration, patient safety, and clinical outcomes. Sedation levels are determined based on criteria such as the patient's level of consciousness, preservation of airway reflexes, adequacy of spontaneous ventilation, and cardiovascular stability. The dose and rate of administration of sedative and analgesic agents, as well as patient-specific clinical characteristics, determine the depth of sedation; inadequate or excessive sedation is associated with patient-ventilator mismatch, hemodynamic instability, and prolonged mechanical ventilation. Therefore, clinical guidelines recommend that sedation management be goal-oriented, protocol-based, and conducted within a framework of systematic assessment. In Turkey, sedation management is carried out according to a plan determined by the physician, but the effectiveness of the process largely depends on the continuous assessment and decision-making process carried out by the nurse at the bedside. Nurses titrate medications by assessing the patient's immediate clinical condition and depth of sedation, detect potential side effects early, and actively manage the achievement of goals. In this context, nurses are not merely implementers; they are healthcare professionals who play a central role in ensuring that sedation is safe, effective, and individualized. This review examines the effects of nurse-controlled sedation protocols on the mechanical ventilation process and the contribution of nurses' clinical knowledge and practices in sedation management to patient outcomes, based on findings from the current literature.

Keywords

Supporting Institution

This research did not receive any financial support from any funding agency or industry.

Ethical Statement

This study is a review article; therefore, ethics committee approval was not required.

References

  1. Aitken, L. M., Bucknall, T., Kent, B., Mitchell, M., Burmeister, E., & Keogh, S. (2016). Sedation protocols to reduce duration of mechanical ventilation in the ICU. Journal of Advanced Nursing, 72(2), 261–272.
  2. Al-Bkkour, A. M., Al-Omar, R. K., Kabba, S. I., & Abou Zied, W. R. (2025). Effect of a nurse-led sedation protocol on sedation quality in patients with traumatic brain injury: A randomized trial. Journal of Neurocritical Care, 18(2), 95–105.
  3. Benzoni, T., Agarwal, A., & Cascella, M. (2025). Procedural sedation. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK551685
  4. Boncyk, C., Rolfsen, M. L., Richards, D., Stollings, J. L., Mart, M. F., Hughes, C. G., & Ely, E. W. (2024). Management of pain and sedation in the intensive care unit. BMJ, 387, bmj-2024-079789.
  5. Çelik, P., & Aydın, H. T. (2017). Yoğun bakım ünitesinde hemşire kontrollü sedasyon protokollerinin kullanımı. Yoğun Bakım Hemşireliği Dergisi, 21(2), 50–54.
  6. Devlin, J.W., Skrobik, Y., Gélinas, C., Needham, D.M., Slooter, A. J. C., Pandharipande, P.P., Watson, P.L., Weinhouse, G.L., Nunnally, M.E., Rochwerg, B., Balas, M.C., van den Boogaard, M., Bosma, K.J., Brummel, N. E., Chanques, G.,
  7. Denehy, L., Drouot, X., Fraser, G.L., Harris, J.E., … Alhazzani, W. (2018). Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Critical Care Medicine, 46(9), e825–e873.
  8. Dreyfus, L., Javouhey, E., Denis, A., Touzet, S., & Bordet, F. (2017). Implementation and evaluation of a paediatric nurse-driven sedation protocol in a paediatric intensive care unit. Annals of Intensive Care, 7(1), 36.

Details

Primary Language

English

Subjects

ICU Nursing

Journal Section

Review

Authors

Dilek Kaya
Türkiye

Publication Date

May 31, 2026

Submission Date

February 13, 2026

Acceptance Date

May 30, 2026

Published in Issue

Year 2026 Volume: 2 Number: 2

APA
Akduran, F., & Kaya, D. (2026). Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review. Northern Journal of Health Sciences, 2(2), 135-143. https://doi.org/10.71340/njhs.1888352
AMA
1.Akduran F, Kaya D. Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review. Northern Journal of Health Sciences. 2026;2(2):135-143. doi:10.71340/njhs.1888352
Chicago
Akduran, Funda, and Dilek Kaya. 2026. “Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review”. Northern Journal of Health Sciences 2 (2): 135-43. https://doi.org/10.71340/njhs.1888352.
EndNote
Akduran F, Kaya D (May 1, 2026) Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review. Northern Journal of Health Sciences 2 2 135–143.
IEEE
[1]F. Akduran and D. Kaya, “Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review”, Northern Journal of Health Sciences, vol. 2, no. 2, pp. 135–143, May 2026, doi: 10.71340/njhs.1888352.
ISNAD
Akduran, Funda - Kaya, Dilek. “Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review”. Northern Journal of Health Sciences 2/2 (May 1, 2026): 135-143. https://doi.org/10.71340/njhs.1888352.
JAMA
1.Akduran F, Kaya D. Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review. Northern Journal of Health Sciences. 2026;2:135–143.
MLA
Akduran, Funda, and Dilek Kaya. “Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review”. Northern Journal of Health Sciences, vol. 2, no. 2, May 2026, pp. 135-43, doi:10.71340/njhs.1888352.
Vancouver
1.Funda Akduran, Dilek Kaya. Nurse-Controlled Sedation Protocols in the Intensive Care Unit: An Evidence-Based Traditional Review. Northern Journal of Health Sciences. 2026 May 1;2(2):135-43. doi:10.71340/njhs.1888352