Investigation of Lipid Peroxidation and Antioxidant Enzyme Activity in Sleep Apnea Patients

Abstract

Aim:The goal of this study was to investigate the activities of malondialdehyde (MDA), a product of lipid peroxidation, and glutathione peroxidase (GPx), anantioxidant enzyme, in sleep apnea patients.

Method: The study involved 40 healthy control patients and 40 sleep apnea patients.  Participants in the experimental group were between the ages of 18 and 65, were diagnosed and treated in the Respiratory Diseases Clinic of Yüzüncü Yıl University Medical Faculty.  Malondialdehyde (MDA) and glutathione peroxidase (GPx) levelsin blood samples were measured using spectrophotometry.

Findings:  According to our results, the difference in the enzyme activity of glutathione peroxidase (GPx) between the experimental group (0.03 ± 0.04U/ml) and the control group (0.06 ± 0.03 U/ ml) was significant (p<0.001).MDA levels were determined to be3.292 U/L (± 0.724U/L) in the experimental groupand 0.882 U/L (± 0.226) in the control group (p<0.001).

Conclusion:  Based on our results, we can conclude that sleep apnea causes a decrease in the GPx enzyme, by means of the body’s antioxidant defense system,and an increase in malondialdehyde, a symptom of oxidative stress.

 

Keywords

• Sleep Apnea,MDA; GPx

Investigation of Lipid Peroxidation and Antioxidant Enzyme Activity in Sleep Apnea Patients

Öz

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