Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation

Murat Aydın; Nurten Nur Aydın; Mehtap Hülya Aslan

doi:10.56766/ntms.1862290

Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation

Abstract

This study aimed to evaluate antibiotic resistance rates of Klebsiella isolates obtained from patients in the intensive care unit (ICU) of a tertiary hospital. Klebsiella isolates cultured from clinical specimens of adult ICU patients between June 2021 and December 2023 were analyzed retrospectively. Demographic data and microbiological results were obtained from the hospital information system. A total of 416 Klebsiella strains were isolated from 337 patients. The mean age was 71±14.9 years, with 52.2% male. The most common sample type was tracheal aspirate (44.0%), followed by urine (27.6%), blood (18.3%), and other specimens (9.1%). Extended-spectrum beta-lactamase (ESBL) production was detected in 326 isolates (78.4%). In this group, resistance to imipenem and meropenem was found to be 66.3% and 68.1%, respectively, while both rates were 1.1% among ESBL-negative isolates. Colistin resistance was observed in 17.8% of ESBL-positive strains, while only one (1.1%) ESBL-negative isolate was resistant. Overall resistance rates to carbapenems were 52.2% for imipenem and 53.6% for meropenem. The highest overall resistance rates were for ceftriaxone (78.4%), ceftazidime (77.2%), and ciprofloxacin (69.5%). The lowest resistance rates were observed for amikacin (31.0%) and colistin (14.2%). Annually, ESBL positivity rose from 73.7% in 2021 to 75.5% in 2022 and 83.1% in 2023. High rates of ESBL production and carbapenem resistance have been observed among Klebsiella isolates from ICUs, with carbapenem resistance exceeding 65% in ESBL-positive isolates, thereby limiting empirical treatment options. These findings underscore the urgent need to develop up-to-date antibiotic policies based on local resistance data and to strengthen effective antibiotic management programmes.

Keywords

References

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Details

Primary Language

English

Subjects

Infectious Diseases

Journal Section

Research Article

Authors

Murat Aydın ^*
0000-0002-0167-0802
Türkiye

Nurten Nur Aydın
0000-0003-4138-2490
Türkiye

Mehtap Hülya Aslan
0000-0002-8455-5120
Türkiye

Publication Date

June 30, 2026

Submission Date

January 13, 2026

Acceptance Date

June 24, 2026

Published in Issue

Year 2026 Volume: 7 Number: 2

DOI

https://doi.org/10.56766/ntms.1862290

IZ

https://izlik.org/JA79JA96AW

Cite

RIS / Bibtex

APA

Aydın, M., Aydın, N. N., & Aslan, M. H. (2026). Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation. New Trends in Medicine Sciences, 7(2), 47-52. https://doi.org/10.56766/ntms.1862290

AMA

1.Aydın M, Aydın NN, Aslan MH. Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation. New Trend Med Sci. 2026;7(2):47-52. doi:10.56766/ntms.1862290

Chicago

Aydın, Murat, Nurten Nur Aydın, and Mehtap Hülya Aslan. 2026. “Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation”. New Trends in Medicine Sciences 7 (2): 47-52. https://doi.org/10.56766/ntms.1862290.

EndNote

Aydın M, Aydın NN, Aslan MH (June 1, 2026) Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation. New Trends in Medicine Sciences 7 2 47–52.

IEEE

[1]M. Aydın, N. N. Aydın, and M. H. Aslan, “Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation”, New Trend Med Sci, vol. 7, no. 2, pp. 47–52, June 2026, doi: 10.56766/ntms.1862290.

ISNAD

Aydın, Murat - Aydın, Nurten Nur - Aslan, Mehtap Hülya. “Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation”. New Trends in Medicine Sciences 7/2 (June 1, 2026): 47-52. https://doi.org/10.56766/ntms.1862290.

JAMA

1.Aydın M, Aydın NN, Aslan MH. Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation. New Trend Med Sci. 2026;7:47–52.

MLA

Aydın, Murat, et al. “Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation”. New Trends in Medicine Sciences, vol. 7, no. 2, June 2026, pp. 47-52, doi:10.56766/ntms.1862290.

Vancouver

1.Murat Aydın, Nurten Nur Aydın, Mehtap Hülya Aslan. Antibiotic Resistance Profile of Klebsiella Isolates from Intensive Care Units: A Retrospective Evaluation. New Trend Med Sci. 2026 Jun. 1;7(2):47-52. doi:10.56766/ntms.1862290