Role of Hyperoside on Ovarian Tissue Damage Created by Ovarian Torsion Detorsion

Abstract

Purpose: Here, hyperoside (HYP) was investigated against ovarian tissue injury induced by bilateral ovarian torsion detorsion (T/D) model. Material and Methods: 18 Sprague Dawley female rats were grouped as sham, torsion detorsion (T/D) and T/D+HYP. Sham group, abdominal incision was performed and repaired with no additional intervention. T/D group, T/D model was established. T/D+HYP group, HYP was administered by oral gavage prior to detorsion. Following detorsion, rats were sacrificed and the ovarian tissues were excised. Results and Conclusion: Oxidant parameters declined and antioxidant values elevated in T/D group compared to sham group. HYP treatment decreased oxidant biomarkers and increased antioxidant mediators. After all, HYP prevented ovarian tissue injury generated by T/D model in rats.

Keywords

• Hyperoside,Ovarian Torsion Detorsion,Ovary,Rat

References

1. 1. Bayer AI, Wiskind AK. Adnexal torsion: can the adnexa be saved? Am J Obstet Gynecol. 1994;171(6):1506-10; discussion 10-1.
2. 2. Oelsner G, Shashar D. Adnexal torsion. Clin Obstet Gynecol. 2006;49(3):459-63.
3. 3. Erkanli Senturk G, Erkanli K, Aydin U, Yucel D, Isiksacan N, Ercan F, et al. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides. 2013;40:82-8.
4. 4. Rey-Bellet Gasser C, Gehri M, Joseph JM, Pauchard JY. Is It Ovarian Torsion? A Systematic Literature Review and Evaluation of Prediction Signs. Pediatr Emerg Care. 2016;32(4):256-61.
5. 5. Smolinski SE, Kreychman A, Catanzano T. Ovarian Torsion: Multimodality Review of Imaging Characteristics. J Comput Assist Tomogr. 2015;39(6):922-4.
6. 6. Kalogeris T, Bao Y, Korthuis RJ. Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol. 2014;2:702-14.
7. 7. Rodrigo R, Libuy M, Feliú F, Hasson D. Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage. Dis Markers. 2013;35(6):773-90.
8. 8. Aycicek A, Ipek A. Maternal active or passive smoking causes oxidative stress in cord blood. European journal of pediatrics. 2008;167(1):81-5.

9. 9. Akcilar R, Akcilar A, Savran B, Ayada C, Kocak C, Kocak FE, et al. Effects of ukrain in rats with intestinal ischemia and reperfusion. The Journal of surgical research. 2015;195(1):67-73.
10. 10. Eraslan E, Tanyeli A, Polat E, Polat E. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol. 2019;234(4):4572-81.
11. 11. Eraslan E, Tanyeli A, Polat E, Yetim Z. Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study. J Cell Biochem. 2019;120(10):17159-66.
12. 12. Ozturk D, Erdogan DG, Tanyeli A, Çomaklı S, Baylan H, Polat E. The protective effects of urapidil on lung tissue after intestinal ischemia-reperfusion injury. 2019;44(4):539.
13. 13. Tanyeli A, author N, Guler M, Eraslan E, Eki F, nci n, et al. Barbaloin attenuates ischemia reperfusion-induced oxidative renal injury via antioxidant and anti-inflammatory effects. 2020;9:246.
14. 14. Dogan C, Halici Z, Topcu A, Cadirci E, Karakus E, Bayir Y, et al. Effects of amlodipine on ischaemia/reperfusion injury in the rat testis. Andrologia. 2016;48(4):441-52.
15. 15. Zou YP, Lu YH, Wei DZ. Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro. J Agr Food Chem. 2004;52(16):5032-9.
16. 16. Conforti F, Statti GA, Tundis R, Menichini F, Houghton P. Antioxidant activity of methanolic extract of Hypericum triquetrifolium Turra aerial part. Fitoterapia. 2002;73(6):479-83.
17. 17. Schettler V, Methe H, Staschinsky D, Schuff-Werner P, Muller GA, Wieland E. Review: the oxidant/antioxidant balance during regular low density lipoprotein apheresis. Ther Apher. 1999;3(3):219-26.
18. 18. Shi YP, Qiu XX, Dai MJ, Zhang XB, Jin GX. Hyperoside Attenuates Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Inhibiting Apoptosis in Rats. Transpl P. 2019;51(6):2051-9.
19. 19. Xiao R, Xiang AL, Pang HB, Liu KQ. Hyperoside protects against hypoxia/reoxygenation induced injury in cardiomyocytes by suppressing the Bnip3 expression. Gene. 2017;629:86-91.
20. 20. Piao MJ, Kang KA, Zhang R, Ko DO, Wang ZH, You HJ, et al. Hyperoside prevents oxidative damage induced by hydrogen peroxide in lung fibroblast cells via an antioxidant effect. Bba-Gen Subjects. 2008;1780(12):1448-57.
21. 21. Ohkawa H, Ohishi N, Yagi K. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem. 1979;95(2):351-8.
22. 22. Sun Y, Oberley LW, Li Y. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem. 1988;34(3):497-500.
23. 23. Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78(3):206-9.
24. 24. Hibbard LT. Adnexal torsion. Am J Obstet Gynecol. 1985;152(4):456-61.
25. 25. Sak ME, Soydinc HE, Sak S, Evsen MS, Alabalik U, Akdemir F, et al. The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. Int J Surg. 2013;11(9):967-70.
26. 26. Ozkisacik S, Yazici M, Gursoy H, Culhaci N. Does gradual detorsion protect the ovary against ischemia-reperfusion injury in rats? Pediatr Surg Int. 2014;30(4):437-40.
27. 27. Ozler A, Turgut A, Soydinç HE, Sak ME, Evsen MS, Alabalik U, et al. The biochemical and histologic effects of adnexal torsion and early surgical intervention to unwind detorsion on ovarian reserve: an experimental study. Reprod Sci. 2013;20(11):1349-55.
28. 28. Yaman Tunc S, Agacayak E, Goruk NY, Icen MS, Turgut A, Alabalik U, et al. Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study. Drug Des Devel Ther. 2016;10:1077-83.
29. 29. A Tanyeli DG. Investigation into the Biochemical Effects of Barbaloin on Renal Tissue in Cecal Ligation and Puncture-Induced Polymicrobial Sepsis Model in Rats. Southern Clinics of Istanbul Eurasia 2019;30:285-9.
30. 30. Ayhan Tanyeli DG. Alliin mitigates Cecal Ligation Puncture (CLP)-induced lung injury through antioxidant and antiinflammatory effects. Turhish Journal of Sciences. 2019;4(2):46-59.
31. 31. Ekinci Akdemir FN TA. The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced by Cecal Ligation and Puncture. 2019;4(1):22-9.
32. 32. Ayhan Tanyeli EE, Mustafa Can Guler, Saime Ozbek Sebin, Demet Celebi, Fatma Betul Ozgeris, Erdem Toktay. Investigation of biochemical and histopathological effects of tarantula cubensis D6 on lung tissue in cecal ligation and puncture-induced polymicrobial sepsis model in rats. Medicine Science International Medical Journal. 2019;8(3):644-50.
33. 33. Ergenoglu M, Erbaş O, Akdemir A, Yeniel A, Yildirim N, Oltulu F, et al. Attenuation of ischemia/reperfusion-induced ovarian damage in rats: does edaravone offer protection? Eur Surg Res. 2013;51(1-2):21-32.
34. 34. Yildirim N, Yigitturk G, Sahingoz Yildirim AG, Akdemir A, İlgen O, Yeniel O, et al. Octreotide protects ovary against ischemia-reperfusion injury in rats: Evaluation of histological and biochemical parameters. J Obstet Gynaecol Res. 2015;41(10):1591-7.
35. 35. Akdemir A, Erbas O, Gode F, Ergenoglu M, Yeniel O, Oltulu F, et al. Protective effect of oxytocin on ovarian ischemia-reperfusion injury in rats. Peptides. 2014;55:126-30.
36. 36. Zhang Y, Zhu J, Guo L, Zou Y, Wang F, Shao H, et al. Cholecystokinin protects mouse liver against ischemia and reperfusion injury. International immunopharmacology. 2017;48:180-6.
37. 37. Meister A. Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacology & therapeutics. 1991;51(2):155-94.
38. 38. Raup-Konsavage WM, Gao T, Cooper TK, Morris SM, Jr., Reeves WB, Awad AS. Arginase-2 mediates renal ischemia-reperfusion injury. American journal of physiology Renal physiology. 2017;313(2):F522-f34.
39. 39. Sengul O, Ferah I, Polat B, Halici Z, Bayir Y, Yilmaz M, et al. Blockade of endothelin receptors with bosentan limits ischaemia/reperfusion-induced injury in rat ovaries. Eur J Obstet Gynecol Reprod Biol. 2013;170(2):458-63.
40. 40. Lutz J, Thürmel K, Heemann U. Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation. J Inflamm (Lond). 2010;7:27.
41. 41. Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev. 2008;88(2):581-609.
42. 42. Kumas M, Altintas O, Karatas E, Kocyigit A. Protective Effect of Ischemic Preconditioning on Myocardium Against Remote Tissue Injury Following Transient Focal Cerebral Ischemia in Diabetic Rats. Arq Bras Cardiol. 2017;109(6):516-26.
43. 43. Soylu Karapinar O, Pinar N, Özcan O, Özgür T, Dolapçıoğlu K. Protective effect of alpha-lipoic acid in methotrexate-induced ovarian oxidative injury and decreased ovarian reserve in rats. Gynecol Endocrinol. 2017;33(8):653-9.
44. 44. Rabus M, Demirbag R, Sezen Y, Konukoglu O, Yildiz A, Erel O, et al. Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2008;36(8):536-40.
45. 45. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-11.
46. 46. Arosio B, Gagliano N, Fusaro LM, Parmeggiani L, Tagliabue J, Galetti P, et al. Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. Pharmacology & toxicology. 2000;87(5):229-33.
47. 47. Wang XX, Fan GM, Wei FM, Bu Y, Huang WH. Hyperoside protects rat ovarian granulosa cells against hydrogen peroxide-induced injury by sonic hedgehog signaling pathway. Chem-Biol Interact. 2019;310.
48. 48. Liu ZY, Tao XY, Zhang CW, Lu YH, Wei DZ. Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide. Biomed Pharmacother. 2005;59(9):481-90.
49. 49. Tanyeli A, Ekinci Akdemir F, Eraslan E, Guler M, Sebin S, Gülçin I. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Kocaeli Medical Journal. 2020;9:166-73.
50. 50. Topdagi O, Tanyeli A, Akdemir FNE, Eraslan E, Guler MC, Comakli S. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life sciences. 2020;242:117217.
51. 51. Derya Guzel AT. Investigation of Chlorogenic Acid (Cga) as An Antioxidant in Renal Ischemia-Reperfusion Injury: An Experimental Study. Sakarya Medical Journal. 2018;8(2):410-5.
52. 52. Derya GÜZEL AT. Investigation of Oxidative Damage of Lung Tissue in Experimental Renal Ischemia Reperfusion Model and The Protective Effects of Chlorogenic Acid (CGA). Sakarya Medical Journal. 2018;8(2):260-5.
53. 53. Ö TOPDAĞI AT, FNE AKDEMİR, DG ERDOĞAN, MC GÜLER. Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study Turkish Journal of Science 4(2).
54. 54. Ayhan Tanyeli FNEA, Ersen Eraslan, Mustafa Can Güler, Saime Özbek Sebin, İlhami Gülçin. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Sakarya Medical Journal. 2020;9(1):166-73.