Stomach Glomus Tumor

Abstract

A glomus tumor is a benign mesenchymal tumor developing either from the neuromuscular glomus cells or from the glomus bodies of the smooth muscle cells. While the gastrointestinal system is rarely the location for glomus tumors, extracutaneous glomus tumors are often encountered in the stomach. This study presents a 36-year-old male patient who applied to the hospital with complaints of nausea and vomiting accompanied by a stomach pain that gradually increased over two days, and the endoscopic inspections have revealed a subepithelial lesion, which was removed with partial gastrectomy. Histopathological evaluations have shown that the tumor is based on the submucosal layer, and had infiltrated into the muscular mucosa. Histopathologic evaluations and immunohistochemical staining had revealed the tumor as a glomus tumor.

Keywords

• stomach mesenchymal tumors,glomus tumors,pathology

References

1. [1] Batra RB, Mehta A, Rama Mohan PV, Singh KJ: Glomus tumor of the stomach. Indian journal of pathology & microbiology 2009, 52:77-9.
2. [2] Liu KL, Wang HP, Tseng WY, Shun CT, Chen SJ, Tsang YM: Glomus tumor of the stomach: MRI findings. AJR American journal of roentgenology 2005, 185:1190-2.
3. [3] Dong LL, Chen EG, Sheikh IS, Jiang ZN, Huang AH, Ying KJ: Malignant glomus tumor of the lung with multiorgan metastases: case report and literature review. OncoTargets and therapy 2015, 8:1909-14.
4. [4] Lee HW, Lee JJ, Yang DH, Lee BH: A clinicopathologic study of glomus tumor of the stomach. Journal of clinical gastroenterology 2006, 40:717-20.
5. [5] Miettinen M, Paal E, Lasota J, Sobin LH: Gastrointestinal glomus tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 32 cases. The American journal of surgical pathology 2002, 26:301-11.
6. [6] Wang LM, Chetty R: Selected unusual tumors of the stomach: a review. International journal of surgical pathology 2012, 20:5-14.
7. [7] Essia Saïji M, Louis Guillou, MD, and Jason L. Hornick, MD, PhD: Epithelioid and Epithelial-like Tumors; Glomus Tumor. Practical soft tissue pathology : a diagnostic approach. Edited by Hornick JL. 1600 John F. Kennedy Blvd.Ste 1800 Philadelphia, PA 19103-2899: by Saunders, an imprint of Elsevier Inc., 2013. pp. 162-5.
8. [8] Fang HQ, Yang J, Zhang FF, Cui Y, Han AJ: Clinicopathological features of gastric glomus tumor. World journal of gastroenterology 2010, 16:4616-20.

9. [9] Orellana F, Onetto C, Balbontin P, Videla D, Manriquez L, Plass R, Araya R, Sepulveda R, Saenz R, Rios H: Gastric glomus tumor: report of one case and review. Endoscopy 2011, 43 Suppl 2 UCTN:E71-2.
10. [10] Tsuneyoshi M, Enjoji M: Glomus tumor: a clinicopathologic and electron microscopic study. Cancer 1982, 50:1601-7.
11. [11] Vassiliou I, Tympa A, Theodosopoulos T, Dafnios N, Fragulidis G, Koureas A, Kairi E: Gastric glomus tumor: a case report. World journal of surgical oncology 2010, 8:19.
12. [12] Nascimento EF, Fonte FP, Mendonca RL, Nonose R, de Souza CA, Martinez CA: Glomus tumor of the stomach: a rare cause of upper gastrointestinal bleeding. Case reports in surgery 2011, 2011:371082.
13. [13] Nagtegaal I, Odze R, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington M, Carneiro F, Cree I: The 2019 WHO classification of tumours of the digestive system - Glomus tumor. Histopathology, 2019. pp. 473-4.
14. [14] Miettinen M: Glomus Tumor, Sinonasal Hemangiopericytoma, and Myopericytoma - Glomus Tumor. Modern soft tissue pathology : tumors and non-neoplastic conditions Edited by Miettinen M. 32 Avenue of the Americas, New York, NY 10013-2473, USA: Cambridge University Press, 2010. pp. 648-9.
15. [15] Campbell MJ, Irani S, Olgac S, Chang LC: Laparoscopic resection of a gastric glomus tumor. The Indian journal of surgery 2011, 73:230-2.
16. [16] Bauerova L, Gabris V, Honsova E, Povysil C: Glomus tumor of the stomach: a case report and review of the literature. Ceskoslovenska patologie 2011, 47:128-9.
17. [17] Kang G, Park HJ, Kim JY, Choi D, Min BH, Lee JH, Kim JJ, Kim KM, Park CK, Sohn TS, Kim S: Glomus tumor of the stomach: a clinicopathologic analysis of 10 cases and review of the literature. Gut and liver 2012, 6:52-7.
18. [18] Folpe AL, Fanburg-Smith JC, Miettinen M, Weiss SW: Atypical and malignant glomus tumors: analysis of 52 cases, with a proposal for the reclassification of glomus tumors. The American journal of surgical pathology 2001, 25:1-12.
19. [19] Chabowski M, Paszkowski A, Skotarczak J, Dorobisz T, Lesniak M, Janczak D, Janczak D: Glomus Tumor of the Stomach - A Case Report and A Literature Review. Polski przeglad chirurgiczny 2016, 88:356-8.
20. [20] Kay S, Callahan WP, Jr., Murray MR, Randall HT, Stout AP: Glomus tumors of the stomach. Cancer 1951, 4:726-36.
21. [21] Yan SL, Yeh YH, Chen CH, Yang CC, Kuo CL, Wu HS: Gastric glomus tumor: a hypervascular submucosal tumor on power Doppler endosonography. Journal of clinical ultrasound : JCU 2007, 35:164-8.
22. [22] Imamura A, Tochihara M, Natsui K, Murashima Y, Suga T, Yaosaka T, Fujinaga A, Koito K, Miyakawa H, Higashino K, et al.: Glomus tumor of the stomach: endoscopic ultrasonographic findings. The American journal of gastroenterology 1994, 89:271-2
23. [23] Agawa H, Matsushita M, Nishio A, Takakuwa H: Gastric glomus tumor. Gastrointestinal endoscopy 2002, 56:903.
24. [24] Lin Y-M, Chiu N-C, Li AF-Y, Liu C-A, Chou Y-H, Chiou Y-Y: Unusual gastric tumors and tumor-like lesions: Radiological with pathological correlation and literature review. World journal of gastroenterology 2017, 23:2493-504.
25. [25] Lindberg MR, Lucas D, Gardner JM, Cassarino DS, Stallings-Archer K: Glomus Tumors (and Variants). DIAGNOSTIC PATHOLOGY: SOFT TISSUE TUMORS, SECOND EDITION. Edited by Lindberg MR. 2 ed. Philadelphia, PA 19103-2899: Elsevier, 2016. pp. 338-43.
26. [26] Vig T, Bindra MS, Kumar RM, Alexander S: Gastric Glomus Tumour Misdiagnosed as Gastric Carcinoid: An Unfamiliar Entity with Aids to Diagnosis and Review of Literature. Journal of clinical and diagnostic research : JCDR 2017, 11:Ed32-ed3.