Comparison of Chloral Hydrate and Hydroxyzine in Pediatric Electroencephalogram Recording; Sedation Successes and Changes in Vital Signs

Abstract

During electroencephalogram (EEG) recording of children, sedatives are frequently needed. It’s reported that Chloral hydrate (CH) and Hydroxyzine (H) have negligible negative effect on EEG and are safe. The effect of CH and H on vital signs has not been studied in detail previously. We compared the sedation success, side effects, and effects on vital signs of CH and H during pediatric EEG recording. A total of 60 children with a mean age of 43.3 ± 33 months (CH) and 39.7 ± 29 months (H) were involved in the study. Oral CH (50 mg/kg) was given to thirty children, and oral H (1 mg/kg) to another 30. Vital signs were recorded during the procedure. Sedation success of CH (96.6%) was higher than H (76.6%) (p=0.023). Mean Ramsay Sedation Score (RSS) of CH (4.8±0.7) was higher than H (3.5±1.6) (p=0.00). The mean procedure time in CH group was significantly longer (p=0.000). The CH significantly reduced the mean systolic and diastolic blood pressure compared to H (p=0.007, p=0.003, respectively). SO2 of a patient from CH group decreased to 87%, and vomiting (6.6%) and agitation (3.3%) were observed in two patients. Our findings indicate that CH, due to it’s higher success rate, can be preferred in children who need sedation for EEG. However, in patients who have limited time, H with a shorter total procedure time can be preferred. More comprehensive studies are required about the effects of decreased blood pressure on systems, caused by CH.

Keywords

• Child
• Chloral hydrate
• Electroencephalogram
• Hydroxyzine
• Sedation

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