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The effect of COVID-19 on autologous cord blood and cord tissue banking in Turkey: a cross-sectional and retrospective study.

Year 2020, Volume: 1 Issue: 2, 90 - 93, 30.09.2020

Abstract

Introduction: Since 1988, when cord blood was used for the first time in bone marrow transplant, over 35,000 units of cord blood have been used successfully. The collection, transfer, processing, and cryopreservation of cord blood and cord tissues have been defined by standardized protocols. There is limited data on autologous cord blood and cord tissue banking in extraordinary cases such as pandemics. Apart from the measures adopted at the global level in the fight against a pandemic, there may be varying practices at the national level. These differences are due to factors such as human behaviors, opportunities to access medical care, number of healthcare professionals, infrastructure of the healthcare institutions, and timing of the measures in different societies. The aim of this study was to retrospectively evaluate the effects of the measures adopted to fight COVID-19 pandemic on autologous cord blood and cord tissue banking in the three-month period following the first case in Turkey.
Materials and Methods: The study was planned as a cross-sectional and retrospective study. The information about the cord blood collected was retrieved from the data recording software called KORDDATA and analyzed at our center. SPSS 21 software was used for statistical analysis. p < 0.05 was considered statistically significant for the Mann–Whitney U test result.
Results: Quantities, transfer times, viability rates, and microbiological contamination rates of cord tissues and cord blood delivered to our center for storage purposes were evaluated and compared with the data from the period of 3 months during which there were no cases. Due to the measures adopted and the restrictions imposed, transfer times were prolonged, but no negative effects were observed on viability and microbiological contamination rates.
Conclusion: This result shows that autologous cord blood and cord tissue banking can continue smoothly in Turkey during the pandemic.

Supporting Institution

Antalya Teknokent Babylife Özel Sağlık Yatırımları San. Tic. A.Ş.

Project Number

2020-SC1

Thanks

I would like to thank statistician Ezgi Afşar Gür for her contributions to the statistical analyses and Antalya Teknokent Babylife Özel Sağlık Yatırımları San. Tic. A.Ş. for their financial support.

References

  • Gluckman E. Umbilical cord blood biology and transplantation. Curr Opin Hematol 1995;2(6) :413‐416.
  • M-Reboredo N, Diaz A, Castro A, Villaescusa RG. Collection, processing and cryopreservation of umbilical cord blood for unrelated transplantation. Bone Marrow Transplant 2000;26(12):1263‐1270.
  • Iafolla MA, Thai J, Allan DS. Transplantation of umbilical cord blood-derived cells for novel indications in regenerative therapy or immune modulation: a scoping review of polystudies. Biol Blood Marrow Transplant 2014;20(1):20‐25.
  • Broxmeyer HE. Enhancing the efficacy of engraftment of cord blood for hematopoietic cell transplantation. Transfus Apher Sci 2016;54(3):364‐372.
  • Model Criteria for Regulation of Cord Blood Banks and Cord Blood Banking: Adopted by the Cord Blood Association, Board of Directors, January 29, 2019. Stem Cells Transl Med 2019; 8(4):340‐343.
  • Mayani H, Wagner JE, Broxmeyer HE. Cord blood research, banking, and transplantation: achievements, challenges, and perspectives. Bone Marrow Transplant 2020;55(1):48‐61.
  • Narayanan DL, Phadke SR. Concepts, Utility and Limitations of Cord Blood Banking: What Clinicians Need to Know. Indian J Pediatricians 2019;86(1):44‐48.
  • Dessels C, Alessandrini M, Pepper MS. Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape. Stem Cells Transl Med 2018;7(9):643‐650.
  • Siddell S, Wege H, Ter Meulen V. The biology of coronaviruses. J Gen Virol 1983;64(Pt 4):761‐776.
  • Atluri S, Manchikanti L, Hirsch JA. Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use. Pain Physician 2020;23(2):E71‐E83.
  • Vaught J. Biobanking During the COVID-19 Pandemic. Biopreserv Biobank. Volume 18, Number 3, 2020
  • Demirbilek Y, Pehlivantürk G, Özgüler ZÖ, Alp Oak E. COVID-19 outbreak control, example of ministry of health of Turkey. Turk J Med Sci 2020;50(L-1):489‐494.
  • Brand A, Rebulla P, Engelfriet CP, et al. Cord blood banking. Vox Sang 2008;95(4):335‐348.
  • Guttridge MG, Soh TG, Belfield H, Sidders C, Watt SM. Storage time affects umbilical cord blood viability. Transfusion 2014;54(5):1278‐1285
Year 2020, Volume: 1 Issue: 2, 90 - 93, 30.09.2020

Abstract

Project Number

2020-SC1

References

  • Gluckman E. Umbilical cord blood biology and transplantation. Curr Opin Hematol 1995;2(6) :413‐416.
  • M-Reboredo N, Diaz A, Castro A, Villaescusa RG. Collection, processing and cryopreservation of umbilical cord blood for unrelated transplantation. Bone Marrow Transplant 2000;26(12):1263‐1270.
  • Iafolla MA, Thai J, Allan DS. Transplantation of umbilical cord blood-derived cells for novel indications in regenerative therapy or immune modulation: a scoping review of polystudies. Biol Blood Marrow Transplant 2014;20(1):20‐25.
  • Broxmeyer HE. Enhancing the efficacy of engraftment of cord blood for hematopoietic cell transplantation. Transfus Apher Sci 2016;54(3):364‐372.
  • Model Criteria for Regulation of Cord Blood Banks and Cord Blood Banking: Adopted by the Cord Blood Association, Board of Directors, January 29, 2019. Stem Cells Transl Med 2019; 8(4):340‐343.
  • Mayani H, Wagner JE, Broxmeyer HE. Cord blood research, banking, and transplantation: achievements, challenges, and perspectives. Bone Marrow Transplant 2020;55(1):48‐61.
  • Narayanan DL, Phadke SR. Concepts, Utility and Limitations of Cord Blood Banking: What Clinicians Need to Know. Indian J Pediatricians 2019;86(1):44‐48.
  • Dessels C, Alessandrini M, Pepper MS. Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape. Stem Cells Transl Med 2018;7(9):643‐650.
  • Siddell S, Wege H, Ter Meulen V. The biology of coronaviruses. J Gen Virol 1983;64(Pt 4):761‐776.
  • Atluri S, Manchikanti L, Hirsch JA. Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use. Pain Physician 2020;23(2):E71‐E83.
  • Vaught J. Biobanking During the COVID-19 Pandemic. Biopreserv Biobank. Volume 18, Number 3, 2020
  • Demirbilek Y, Pehlivantürk G, Özgüler ZÖ, Alp Oak E. COVID-19 outbreak control, example of ministry of health of Turkey. Turk J Med Sci 2020;50(L-1):489‐494.
  • Brand A, Rebulla P, Engelfriet CP, et al. Cord blood banking. Vox Sang 2008;95(4):335‐348.
  • Guttridge MG, Soh TG, Belfield H, Sidders C, Watt SM. Storage time affects umbilical cord blood viability. Transfusion 2014;54(5):1278‐1285
There are 14 citations in total.

Details

Primary Language English
Subjects Clinical Sciences, ​Internal Diseases, Medical Physiology
Journal Section Research Articles
Authors

Durmus Burgucu 0000-0003-3980-982X

Project Number 2020-SC1
Publication Date September 30, 2020
Submission Date August 17, 2020
Published in Issue Year 2020 Volume: 1 Issue: 2

Cite

EndNote Burgucu D (September 1, 2020) The effect of COVID-19 on autologous cord blood and cord tissue banking in Turkey: a cross-sectional and retrospective study. New Trends in Medicine Sciences 1 2 90–93.