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The Role of Trace Elements in Thyroid Cancers

Year 2021, Volume: 2 Issue: 2, 157 - 163, 15.09.2021

Abstract

Thyroid cancer is one of the most common endocrine cancers. Trace elements act as enzyme components in biological systems or as catalysts in chemical reactions in cells. For this reason, it is known that excessive or insufficient intake of many elements causes many diseases, including various types of cancer. This study aims to evaluate the element concentration in thyroid tissue, nodule and serum of thyroid cancer patients.
The study was conducted on a total of 60 participants, 21 malignant and 39 benign. In thyroid tissue, nodule and serum samples obtained from malignant and benign individuals, copper (Cu), zinc (Zn), aluminum (Al), cobalt (Co), iron (Fe), nickel (Ni), silver (Ag), chromium (Cr), selenium (Se), cadmium (Cd), manganese (Mn), arsenic (As) and lead (Pb) were evaluated using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).
Nodule Pb level in the malignant group was found to be significantly higher than that of the nodule Pb in the benign group. In addition, as a result of the evaluation between nodule and tissue in the malignant and benign groups, Al and Mn were higher in the malignant group than in the nodule in the thyroid tissue; Ni, Cu and Se were found to be significantly lower. In addition, Al was higher in the benign group than the nodule in the thyroid tissue, while Ni was significantly lower (p <0.05).
All these results suggest that trace elements have serious roles in the etiology of thyroid cancer.

Supporting Institution

Atatürk University Scientific Research Projects Coordination Unit (BAP).

Project Number

PRJ2016/61

Thanks

This research (Project No: PRJ2016/61) was funded by Atatürk University Scientific Research Projects Coordination Unit (BAP).

References

  • 1. Tan GH, Gharib H. Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging. Ann Intern Med 1997; 126(3):226-231
  • 2. Cibas ES, Ali SZ.The Bethesda System for Reporting Thyroid Cytopathology. Thyroid 2009; 19(11):1159- 1165
  • 3. Crippa S, Mazzucchelli L, Cibas ES, Ali SZ. The Bethesda System for reporting thyroid fine-needle aspiration specimens. Am J Clin Pathol 2010; 134(2):343-344
  • 4. Kurt N. Türkiye’ nin Doğusunda Yaşayan İntestinal Parazitli Çocuklarda Serum Çinko, Selenyum, Bakır, Magnezyum ve Demir Düzeyleri. Institute of Health Sciences, Department of Medical Biochemistry. Master Thesis. Erzurum: Ataturk University 2010.
  • 5. Weinberg, E. D. The role of iron in cancer. Eur. J. Cancer Prev. 1996; 5: 19–36.
  • 6. Z. Pawlowicz, B. A. Zachara, U. Trafikowska, et al., Blood selenium concentrations and glutathione peroxidase activities in patients with breast cancer and with advanced gastrointestinal cancer, J. Trace Elements Electolytes Health Dis. 1991; 5, 275–277
  • 7. M. Kogata, M. Kobayashi, M. Yananura, et al., Selenium levels in malignant and normal tissues of gastroinestinal cancer patients, J. Clin. Biochem. Nutr. 1988; 5, 93–101.
  • 8. M. D. Chen, Y. M. Song, C. T. Tsou, et al., Leptin concentration and the Zn/Cu ration in plasma in women with thyroid disorder, Biol. Trace Element Res. 2000; 75, 99–105
  • 9. G. Saner, S. V. Baysal, E. Ünüvar, et al., Serum zinc, copper levels and copper/zinc ratios in infants with sepsis syndrome, J. Trace Elements Exp. Med. 2000; 13, 265–270
  • 10. Golasik, M., Przybyłowicz, A., Woźniak, A., Herman, M., Gawęcki, W., Golusiński, W., Florek, E. Essential metals profile of the hair and nails of patients with laryngeal cancer. Journal of Trace Elements in Medicine and Biology, 2015; 31: 67-73.
  • 11. Chiang LC, Chang JE, Wen TC. Indirect Oxidation Effect in Flectrochemical Oxidation of Landfill Leachate. Water Research, 1995; 29(2): 671-678.
  • 12. Yücel, F. Arpaci, A. Özet, et al., Serum copper and zinc levels and copper/zinc ration in patients with breast cancer, Biol. Trace Element Res. 1994; 40, 31–38
  • 13. Goodman V, Brewer, G, Merajver S. Copper deficiency as an anti-cancer strategy. Endocrinerelated cancer, 2004; 11(2): 255-263.
  • 14. Costello LC, Franklin RB, TanM, Bagasra O. Zinc and prostate cancer: a critical scientific, medical, and public interest issue (United States). Cancer Causes Control 2005; 16: 901–915.
  • 15. McMurray CT, Tainer JA. Cancer, cadmium and genome integrity. Nature Genetics 2003; 34: 239–241.
  • 16. Waalkes MP. Cadmium carcinogenesis in review. J Inorg Chem 2000; 79:241- 244.
  • 17. Shimada H, Shiao YH, Shibata M, Waalkes MP. Cadmium suppresses apoptosis induced by chromium. J Toxicol Environ Health 1998; 54:159–168.
  • 18. Platz EA, Helzlsouer KJ, Hoffman SC, Morris JS, Basket CK, Comstock GW. Prediagnostic toenail cadmium and zinc and subsequent prostate cancer risk. Prostate 2002; 52: 288–296
  • 19. Celen I, Şenol F, Müezzinoğlu T. Bulletin of Urooncology. The effect of trace elements in prostate cancer. 2011; 2:27-32.
  • 20. Koçak ÖF, Albayrak M, Özgeriş FB. Trace Elements Analysis in Cancer and Healthy Larynx Tissues by ICP-MS Method. Journal of the Institute of Science and Technology, 2020; 10(3): 1779-1785, 2020
  • 21. Msteo M, Martin B, Santos M et al. Catalase activity in erythrocytes from colon and gastric cancer patients. Influence of nickel, lead, mercury and cadmium. Biol. Trace Elem. Res. 1997; 57: 79-90.
Year 2021, Volume: 2 Issue: 2, 157 - 163, 15.09.2021

Abstract

Project Number

PRJ2016/61

References

  • 1. Tan GH, Gharib H. Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging. Ann Intern Med 1997; 126(3):226-231
  • 2. Cibas ES, Ali SZ.The Bethesda System for Reporting Thyroid Cytopathology. Thyroid 2009; 19(11):1159- 1165
  • 3. Crippa S, Mazzucchelli L, Cibas ES, Ali SZ. The Bethesda System for reporting thyroid fine-needle aspiration specimens. Am J Clin Pathol 2010; 134(2):343-344
  • 4. Kurt N. Türkiye’ nin Doğusunda Yaşayan İntestinal Parazitli Çocuklarda Serum Çinko, Selenyum, Bakır, Magnezyum ve Demir Düzeyleri. Institute of Health Sciences, Department of Medical Biochemistry. Master Thesis. Erzurum: Ataturk University 2010.
  • 5. Weinberg, E. D. The role of iron in cancer. Eur. J. Cancer Prev. 1996; 5: 19–36.
  • 6. Z. Pawlowicz, B. A. Zachara, U. Trafikowska, et al., Blood selenium concentrations and glutathione peroxidase activities in patients with breast cancer and with advanced gastrointestinal cancer, J. Trace Elements Electolytes Health Dis. 1991; 5, 275–277
  • 7. M. Kogata, M. Kobayashi, M. Yananura, et al., Selenium levels in malignant and normal tissues of gastroinestinal cancer patients, J. Clin. Biochem. Nutr. 1988; 5, 93–101.
  • 8. M. D. Chen, Y. M. Song, C. T. Tsou, et al., Leptin concentration and the Zn/Cu ration in plasma in women with thyroid disorder, Biol. Trace Element Res. 2000; 75, 99–105
  • 9. G. Saner, S. V. Baysal, E. Ünüvar, et al., Serum zinc, copper levels and copper/zinc ratios in infants with sepsis syndrome, J. Trace Elements Exp. Med. 2000; 13, 265–270
  • 10. Golasik, M., Przybyłowicz, A., Woźniak, A., Herman, M., Gawęcki, W., Golusiński, W., Florek, E. Essential metals profile of the hair and nails of patients with laryngeal cancer. Journal of Trace Elements in Medicine and Biology, 2015; 31: 67-73.
  • 11. Chiang LC, Chang JE, Wen TC. Indirect Oxidation Effect in Flectrochemical Oxidation of Landfill Leachate. Water Research, 1995; 29(2): 671-678.
  • 12. Yücel, F. Arpaci, A. Özet, et al., Serum copper and zinc levels and copper/zinc ration in patients with breast cancer, Biol. Trace Element Res. 1994; 40, 31–38
  • 13. Goodman V, Brewer, G, Merajver S. Copper deficiency as an anti-cancer strategy. Endocrinerelated cancer, 2004; 11(2): 255-263.
  • 14. Costello LC, Franklin RB, TanM, Bagasra O. Zinc and prostate cancer: a critical scientific, medical, and public interest issue (United States). Cancer Causes Control 2005; 16: 901–915.
  • 15. McMurray CT, Tainer JA. Cancer, cadmium and genome integrity. Nature Genetics 2003; 34: 239–241.
  • 16. Waalkes MP. Cadmium carcinogenesis in review. J Inorg Chem 2000; 79:241- 244.
  • 17. Shimada H, Shiao YH, Shibata M, Waalkes MP. Cadmium suppresses apoptosis induced by chromium. J Toxicol Environ Health 1998; 54:159–168.
  • 18. Platz EA, Helzlsouer KJ, Hoffman SC, Morris JS, Basket CK, Comstock GW. Prediagnostic toenail cadmium and zinc and subsequent prostate cancer risk. Prostate 2002; 52: 288–296
  • 19. Celen I, Şenol F, Müezzinoğlu T. Bulletin of Urooncology. The effect of trace elements in prostate cancer. 2011; 2:27-32.
  • 20. Koçak ÖF, Albayrak M, Özgeriş FB. Trace Elements Analysis in Cancer and Healthy Larynx Tissues by ICP-MS Method. Journal of the Institute of Science and Technology, 2020; 10(3): 1779-1785, 2020
  • 21. Msteo M, Martin B, Santos M et al. Catalase activity in erythrocytes from colon and gastric cancer patients. Influence of nickel, lead, mercury and cadmium. Biol. Trace Elem. Res. 1997; 57: 79-90.
There are 21 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other)
Journal Section Research Articles
Authors

Özge Nur Türkeri 0000-0001-8791-5331

Nezahat Kurt 0000-0002-1685-5332

Mustafa Yeni 0000-0003-2384-2094

Fatma Betül Özgeriş 0000-0002-4568-5782

Mehmet Ali Gül 0000-0002-5849-0116

Nuri Bakan 0000-0002-2139-7268

Erdem Karadeniz 0000-0001-6319-1754

Müfide Nuran Akçay 0000-0001-8470-1741

Project Number PRJ2016/61
Publication Date September 15, 2021
Submission Date July 25, 2021
Published in Issue Year 2021 Volume: 2 Issue: 2

Cite

EndNote Türkeri ÖN, Kurt N, Yeni M, Özgeriş FB, Gül MA, Bakan N, Karadeniz E, Akçay MN (September 1, 2021) The Role of Trace Elements in Thyroid Cancers. New Trends in Medicine Sciences 2 2 157–163.