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Radiological Characteristics of Immunization Adenitis in the Axilla Following the Covid-19 Vaccine

Year 2023, Volume: 4 Issue: Supplemental Issue, 163 - 168, 20.10.2023
https://doi.org/10.56766/ntms.1341236

Abstract

It was aimed to investigate the ultrasonography (US) features of axillary COVID-19 immunization adenitis. Patients with axillary COVID-19 immunization adenitis detected between April 2021 and January 2022 were included. US features of the lymph nodes identified at the patient's initial US were all recorded. Radiological follow-up information and if exists pathology results were investigated. 104 immunization adenitis in the axilla following Covid-19 vaccine were detected. Only 18.3 percent had axillary pain or edema. Biopsy was recommended for 4 patients and follow-up was recommended for the other 100 patients. Core biopsy results were lymphoid tissue with focal micro-abscess formations, reactive lymphoid hyperplasia and plasma cell increase. All of the patients had a history of vaccination in the last 3 months. After immunization, initial US imaging was conducted mean 24-days later. The mean long and short axis were 22-mm and 13-mm, respectively. The mean long-short axes ratio was 2.2. The mean thickness of the cortex was 4.8-mm. The long and short axes of the lymph nodes in the first US and control examinations were compared statistically and they decreased in time. The hilum existed (96%). Elastography revealed soft features. The majority of the immunization adenitis are just enlarged benign-appearing lymph nodes. The majority were found during the extensive immunization campaign and were asymptomatic. Patients and their physicians should be aware of the vaccination and imaging evaluation of specific patient groups considering that these vaccinations will continue to be used for a while in the next years.

Project Number

-

References

  • 1. https://www.who.int/health-topics/vaccines-and-immunization#tab=tab_1
  • 2. Wendt S, Trawinski H, Pietsch C, Borte M, Lübbert C. Impfungen [Vaccinations]. Internist (Berl). 2021; 62(12):1295-309.
  • 3. https://www.cdc.gov/vaccines/pubs/pinkbook/genrec.html
  • 4. Lapin JH, Tuason J. Immunization adenitis. J Am Med Assoc. 1955 Jun 11;158(6):472.
  • 5. Studdiford J, Lamb K, Horvath K, Altshuler M, Stonehouse A. Development of unilateral cervical and supraclavicular lymphadenopathy after human papilloma virus vaccination. Pharmacotherapy. 2008; 28(9):1194-97.
  • 6. Durur-Subasi I, Karaman A, Demirci E, Sipal S, Akcay MN. The benign mimickers of carcinoma on breast MRI. J Mind Med Sci. 2022; 9(1):96-101.
  • 7. Yuan QQ, Xiao SX, Farouk O, et al. Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition). Mil Med Res. 2022; 9(1):20.
  • 8. Durur Subaşı I. Breast Imaging for Non-radiologists. Erciyes Med J. 2022; 44(2):129-37.
  • 9. Ko D, Han JW, Youn J, Yang HB, Oh C, Yun KW, Kim HY. Clinical Course of Bacillus Calmette-Guerin Lymphadenitis. Children (Basel). 2022; 9(5):610.
  • 10. Expert Panel on Breast Imaging, Le-Petross HT, Slanetz PJ, et al. ACR Appropriateness Criteria® Imaging of the Axilla. J Am Coll Radiol. 2022; 19(5S):S87-S113.
  • 11. Mortazavi S. COVID-19 Vaccination-Associated Axillary Adenopathy: Imaging Findings and Follow-Up Recommendations in 23 Women. AJR Am J Roentgenol. 2021; 217(4):857-58.
  • 12. Dialani V, James DF, Slanetz PJ. A practical approach to imaging the axilla. Insights Imaging. 2015; 6(2):217-29.
  • 13. Yoshimura G, Sakurai T, Oura S, Suzuma T, Tamaki T, Umemura T, Kokawa Y, Yang Q. Evaluation of Axillary Lymph Node Status in Breast Cancer with MRI. Breast Cancer. 1999; 6(3):249-58.
  • 14. Schiaffino, S., Pinker, K., Magni, V. et al. Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging (EUSOBI). Insights Imaging. 2021; 12:119.
  • 15. US Centers for Disease Control. Local reactions, systemic reactions, adverse events, and serious adverse events: Moderna COVID-19 Vaccine. Accessed June 15, 2021. https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/reactogenicity.html
  • 16. Robinson KA, Maimone S, Gococo-Benore DA, Li Z, Advani PP, Chumsri S. Incidence of Axillary Adenopathy in Breast Imaging After COVID-19 Vaccination. JAMA Oncol. 2021; 7(9):1395-97.
  • 17. Subasi M, Duger M, Erol C, Durur-Subasi I. Opportunistic retrospective assessment of HUAC, bone density, SFT and breast density on CT images and relationship with severity of COVID-19. J Mind Med Sci. 2023; 10(1):148-55.
Year 2023, Volume: 4 Issue: Supplemental Issue, 163 - 168, 20.10.2023
https://doi.org/10.56766/ntms.1341236

Abstract

Supporting Institution

yok

Project Number

-

References

  • 1. https://www.who.int/health-topics/vaccines-and-immunization#tab=tab_1
  • 2. Wendt S, Trawinski H, Pietsch C, Borte M, Lübbert C. Impfungen [Vaccinations]. Internist (Berl). 2021; 62(12):1295-309.
  • 3. https://www.cdc.gov/vaccines/pubs/pinkbook/genrec.html
  • 4. Lapin JH, Tuason J. Immunization adenitis. J Am Med Assoc. 1955 Jun 11;158(6):472.
  • 5. Studdiford J, Lamb K, Horvath K, Altshuler M, Stonehouse A. Development of unilateral cervical and supraclavicular lymphadenopathy after human papilloma virus vaccination. Pharmacotherapy. 2008; 28(9):1194-97.
  • 6. Durur-Subasi I, Karaman A, Demirci E, Sipal S, Akcay MN. The benign mimickers of carcinoma on breast MRI. J Mind Med Sci. 2022; 9(1):96-101.
  • 7. Yuan QQ, Xiao SX, Farouk O, et al. Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition). Mil Med Res. 2022; 9(1):20.
  • 8. Durur Subaşı I. Breast Imaging for Non-radiologists. Erciyes Med J. 2022; 44(2):129-37.
  • 9. Ko D, Han JW, Youn J, Yang HB, Oh C, Yun KW, Kim HY. Clinical Course of Bacillus Calmette-Guerin Lymphadenitis. Children (Basel). 2022; 9(5):610.
  • 10. Expert Panel on Breast Imaging, Le-Petross HT, Slanetz PJ, et al. ACR Appropriateness Criteria® Imaging of the Axilla. J Am Coll Radiol. 2022; 19(5S):S87-S113.
  • 11. Mortazavi S. COVID-19 Vaccination-Associated Axillary Adenopathy: Imaging Findings and Follow-Up Recommendations in 23 Women. AJR Am J Roentgenol. 2021; 217(4):857-58.
  • 12. Dialani V, James DF, Slanetz PJ. A practical approach to imaging the axilla. Insights Imaging. 2015; 6(2):217-29.
  • 13. Yoshimura G, Sakurai T, Oura S, Suzuma T, Tamaki T, Umemura T, Kokawa Y, Yang Q. Evaluation of Axillary Lymph Node Status in Breast Cancer with MRI. Breast Cancer. 1999; 6(3):249-58.
  • 14. Schiaffino, S., Pinker, K., Magni, V. et al. Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging (EUSOBI). Insights Imaging. 2021; 12:119.
  • 15. US Centers for Disease Control. Local reactions, systemic reactions, adverse events, and serious adverse events: Moderna COVID-19 Vaccine. Accessed June 15, 2021. https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/reactogenicity.html
  • 16. Robinson KA, Maimone S, Gococo-Benore DA, Li Z, Advani PP, Chumsri S. Incidence of Axillary Adenopathy in Breast Imaging After COVID-19 Vaccination. JAMA Oncol. 2021; 7(9):1395-97.
  • 17. Subasi M, Duger M, Erol C, Durur-Subasi I. Opportunistic retrospective assessment of HUAC, bone density, SFT and breast density on CT images and relationship with severity of COVID-19. J Mind Med Sci. 2023; 10(1):148-55.
There are 17 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Research Articles
Authors

Mustafa Düger 0000-0002-4091-6465

Abdulkadir Eren 0000-0003-0958-6581

Project Number -
Publication Date October 20, 2023
Submission Date August 11, 2023
Published in Issue Year 2023 Volume: 4 Issue: Supplemental Issue

Cite

EndNote Düger M, Eren A (October 1, 2023) Radiological Characteristics of Immunization Adenitis in the Axilla Following the Covid-19 Vaccine. New Trends in Medicine Sciences 4 Supplemental Issue 163–168.