The Toxic Effects on the Testis of Flutamide vs. Bicalutamide vs. Cyproterone Acetate: An Experimental Rat Study

Year 2024, Volume: 5 Issue: 2, 84 - 90, 30.05.2024

Metin Gür , Eyüp Dil , Ekrem Akdeniz , Ümit Çobanoğlu , Nuri İhsan Kalyoncu , Murat Topbaş , Rasin Özyavuz

https://doi.org/10.56766/ntms.1441182

Abstract

The aim of this study was to investigate the toxic effects on the rat testis of flutamide, bicalutamide, and cyproterone acetate using histopathological methods. Twenty-four male Sprague-Dawley rats were randomly divided into four groups, control (Group 1), flutamide (Group 2), bicalutamide (Group 3), and cyproterone acetate (Group 4). Physiological saline solution or anti-androgens were administered via oral gavage for 14 days. At the end of the study, the testes were harvested for histological toxic effect scoring. The mean histopathology scores were 0 in Group 1, 0.33 ± 0.81 in Group 2, 1.66 ± 1.36 in Group 3, and 2.93 ± 0.98 in Group 4. The histopathology score in Group 4 was significantly higher than that in Group 1 (p = 0.002), but was not significantly different to those in groups 2 and 3 (p = 0.317 and p = 0.028, respectively). No significant difference was also observed between the other groups. Cyproterone acetate, a steroidal antiandrogen, resulted in significant impairment of testis histology relative to the non-steroidal antiandrogens flutamide and bicalutamide. A non-steroidal agent such as flutamide or bicalutamide should therefore be selected if antiandrogen therapy is to be initiated for reasons such as acne, hirsutism, and paraphilias, particularly in young males.

Keywords

Flutamide, bicalutamide, cyproterone acetate, testis, histopathology

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