CEREBROSPINAL FLUID (CSF) IL-17A, IL-17F, IL-34 AND CXCL-13 LEVELS IN AMYOTROPHIC LATERAL SCLEROSIS (ALS/MND) PATIENTS

Year 2019, Volume: 14 Issue: 3, 154 - 162, 08.07.2019

Hayriye Orallar Şeyda Karabörk Bihter Gökçe Bozat Şule Aydın Türkoğlu

Abstract

In this study, our clinic follow-up ALS/MND diagnose the cerebrospinal fluid of patients (CSF), IL-17A, IL-17F, IL-34 cytokines and CXCL-13 chemokine to evaluate the levels. that were determined by ELISA. In our study, significantly higher in the patient group and the proinflammatory cytokine, IL-17A and IL-17F of endothelial cells, fibroblasts and also known to be expressed in neurones. However, CXCL13 level is considered among the patient group and the control group was not statistically significant difference. IL-34 also to be increased when compared to the patient group (n=4) than the control group (n=6), a recently described cytokine due to the IL-34 Th17 with modulating immune pathogenesis and immune with cytokines released from cells in a short time to be involved ALS/MND such as rare as to be made further studies for the diagnosis of a disease to a powerful new biomarker may and science has been suggested to contribute in this respect. 

Keywords

ALS/MND, IL-17, IL-34, CXCL-13, Patient

Cerebrospinal Fluid (CSF) IL-17A, IL-17F, IL-34 and CXCL-13 Levels in Amyotrophic Lateral Sclerosis (ALS/MND) Patients

Abstract

     In this study, our clinic follow-up ALS/MND diagnose
the cerebrospinal fluid of patients (CSF), IL-17A, IL-17F, IL-34 cytokines and
CXCL-13 chemokine to evaluate the levels. that were determined by ELISA. In our
study, significantly higher in the patient group and the proinflammatory
cytokine, IL-17A and IL-17F of endothelial cells, fibroblasts and also known to
be expressed in neurones. However, CXCL-13 level is considered among the
patient group and the control group was not statistically significant difference.
IL-34 also to be increased when compared to the patient group (n=4) than the
control group (n=6), a recently described cytokine due to the IL-34 Th17 with
modulating immune pathogenesis and immune with cytokines released from cells in
a short time to be involved ALS/MND such as rare as to be made further studies
for the diagnosis of a disease to a powerful new biomarker may and science has
been suggested to contribute in this respect.

Keywords

ALS/MND, IL-17, IL-34, CXCL-13, Patient

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