TİYOSEMİKARBAZON VE METAL KOMPLEKSLERİNİN RATLARDA SERUM AMİNO ASİT DÜZEYLERİNE ETKİSİ

Year 2013, Volume: 8 Issue: 1, 32 - 38, 01.02.2013

Mustafa Karatepe

Abstract

Tiyosemikarbazon ve Schiff bazlarının çeşitli türevleri ve bunların metal kompleksleri antitümör, antineoplastik, antiviral, antibakteriyel, antimalarial gibi biyolojik fonksiyonlarından dolayı kimya, biyoloji ve farmakoloji bilim dallarında büyük ilgi görmektedir. Ayrıca bu bileşiklerin yapı aktivite ilişkisi (QSAR) araştırmaları birçok çalışmaya konu olmaktadır. Bu çalışmada, Tiyosemikarbazon türevi bileşiklerin ve metal komplekslerinin serum amino asit düzeylerine etkisi incelendi. Yapılan çalışmalar sonucunda, bileşiklerin serum amino asit düzeylerini azalttığı görülmüştür.

Keywords

Tiyosemikarbazon, metal kompleksi, serum, amino asit, rat,

SERUM AMINO ACID LEVELS WITH THIOSEMICARBAZONE DERIVATIVES AND ITS METAL COMPLEXES TREATED RATS

Abstract

Thiosemicarbazone (TSC) and Schiff base (SB) derivatives have raised considerable interest in chemistry, biology and pharmacology due to their antitumor, antibacterial, antimalarial, antineoplastic and antiviral activities. In addition, many studies have focused on qualitative structure activity relationship (QSAR) of the compounds. In this study, effects of the serum free amino acid level of the thiosemicarbazone and its metal complexes on rats. Our findings indicate that all compounds were decreased serum amino acid levels.

Keywords

Thiosemicarbazone, metal complex, serum, amino acid, rat,

References

• Liberta, A.E. and West, D.X., (1992). Antifungal and Antitumour Activity of Heterocyclic Thiosemicarbazones and Their Metal Complexes, Biometals, 5, 121-126.
• Demertzi, D.K., Domopoulou, A., Demertzis, M.A., Valle, G., and Papageorgiou, A., (1997). Palladium (II) Complexes of 2Acetylpyridine N(4)-Methyl, N(4)-Ethyl and N(4)-Phenyl Thiosemicarbazones. Crystal Structure of Chloro (2-Acetylpyridine N(4)-Methylthiosemicarbazonato) Palladium (II). Synthesis, Spectral Studies, In Vitro and In Vivo Antitumour Activity, J. of Inorg. Biochem., 68, 147-155.
• Offing, O.E. and Martelli, S., (1994). Antibacterial Activity of Metal Complexes of Benzyl and Benzoin Thiosemicarbazones, IL Farmaco, 49 (7,8), 513-518.
• Chan-Stier, C.H., Minkel, D., and Petering, D.H., (1976). Reactions of bis (Thiosemicarbazonato) Copper (II) Complexes with Tumor Cells and Mitochondria, Bioinorganic Chem., 6 (3), 203-217. Durackova, Z., Mendiola, M.A., Sevilla, M.T., and Valent, A., (1999). Thiohydrazone Copper (II) Complexes. The Relationship Between Redox Properties and Superoxide Dismutase Mimetic Activity, Bioelectrochemistry and Bioenergetics, 48, 109-116.
• Rohde, W., Cordell, B., Webster, R., and Levinson, W., (1977). Inhibition of Amino Acyl tRNA Synthetase Activity by Copper Complexes of Two Metalbinding Ligands, Biochemica et Biophy. Acta, 477, 102-111.
• Öner, H., Karatepe, M., Karatas, F., Öner, J., Yilmaz, I., and Cukurovalı, A. (2004) Effects on the rat testes of thiosemicarbazone derivative schiff base (4-(1-PhenylMethylcyclobutane-3-yl)-2-(2-Hydroxybenzylidenehydrazino) Thiazole) and its cadmium (II) complex. Cell Biochem. And Function, 22, 1-7.
• Karatepe, M. and Karatas, F., (2006). Antioxidant, Pro-Oxidant Effect of the Thiosemicarbazone Derivative Schiff Base (4-(1Phenylmethylcyclobutane-3-Yl)-2-(2 Hydroxybenzylidenehydrazino) Thiazole) and its Metal Complexes on Rats.” Cell Biochem. And Function, 24(6), 547-554.
• Chapman, J.M., Delucy, P., Wong, O.T., and Hall, I.H., (1990). Structure Activity Relationship of Imido N-Alkyl Semicarbazones, Thiosemicarbazones and Acethydrazones as Hypolipidemic Agents in Rodents, Lipids, 25 (7), 391-397.
• Kumamoto, T., Toyooka, K., Nishida, M., Kuwahara, H., Yoshimura, Y., Kawada, J., and Kubota, S., (1990) Effect of 2,4-Dihydro-3H1,2,4-Triazole-3-Thiones and Thiosemicarbazones on Iodide Uptake by the Mouse Thyroid: The Relationship Between Their Structure and Anti- Thyroid Activity. Chem. Pharm. Bull., 38(9): 2596-2596.
• Strehler, B.L., Schmid, P., Li, M.P., Martin, K., and Fliss, H., (1982). Oxidative Peptide (and Amide) Formation from Schiff Base Complexes. J. Mol. Evol., 19(1): 1-8.
• Chapman, J.M., Delucy, P., Wong, O.T., and Hall, I.H., (1990). Structure Activity Relationship of Imido N-Alkyl Semicarbazones, Thiosemicarbazones and Acethydrazones as Hypolipidemic Agents in Rodents, Lipids, 25 (7), 391-397.
• Papageorgiou, Z., Iakovidou, D.M., Mioglou, E., Boutis, L., Kotsis, A., Demertzi, D.K., Domopoulou, A., West, D.X., and Demertzis, M.A., (1997). Antineoplastic and Cytogenetic Effects of Complexes of Pd (II) with 4N-Substituted Derivatives of 2-AcetylPyridine-Thiosemicarbazone, Anticancer Research, 17, 247-252.
• Liu, C.M., Lin, T.S., and Sartorelli, A.C., (1992). Synthesis and Antitumor Activity of Amino Derivatives of Pyridine-2Carboxoldehyde Thiosemicarbazone, J. Med. Chem., 35, 3672-3677.
• Mitja, K., Irma, V.K., and Mirko, P., (2007). Determination of derivatized amino acids in human embryo culture media by gas chromatography. Journal of Chromatography B.; 858: 292–295.
• Liberta, A.E. and West, D.X., (1992). Antifungal and Antitumour Activity of Heterocyclic Thiosemicarbazones and Their Metal Complexes, Biometals, 5, 121-126.
• Liu CM, Lin TS, and Sartorelli AC. (1992). Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J. Med. Chem.; 35: 3672-3677.
• Murray, R.K., Mayes, P.A., Granner, D.K., and Rodwell, V.W., (1993). Harper'in Biyokimyası (Çev. Ed. Menteş, G., Ersöz, B), Barış Kitapevi, İstanbul.
• Teitz, Y., Barko, N., Abramoff, M., and Ronen, D., (1994). Relationship Between Structure and Antiretroviral Activity of Thiosemicarbazone Derivatives, Chemotherapy, 40, 195-200.
• Rohde, W., Shafer, R., Idriss, T., Levinson, W., (1979). Binding of N-Methyl Isatin Beta - Thiosemicarbazone - Copper Complexes to Proteins and Nucleic Acids, J. Inorganic Biochem., 10 (3), 183-94. Satoh, A., Histomi, M., and Igarashi, K., (1995). Effects of Spinach Leaf Protein Concentrate on The Cholesterol and Amino Acid Concentrations in Rats Fed a Cholesterol - Free Diet, J. of Nutritional Sci. and Vit., 41 (5), 563-573.