The Relationship The Leptin Hormone, Obesity and Diabetes

Year 2020, Volume: 15 Issue: 2, 40 - 48, 23.04.2020

Aysel Sarı , Mateen Bahjat Sadeq

Abstract

           Leptin, which is adipocytes, secreted of the hormone, over food intake regulation, energy expenditure has also an important role in acting as neuroendocrine hormone, and metabolic function.it is interested in glucose metabolism and interacts with insulin metabolism. In addition to distrusting metabolism, leptin also impairs endocrine, immune functions, reproductive function, adipose tissue metabolism and energy order. Leptin also exerts peripheral effects directly on glucose metabolism and gluconeogenesis. it is obvious that leptin deficiency or leptin resistance is responsible for obesity which is also correlated with body fat stores, here we have to refer that is the obesity is one of the most causes of diabetes also it leads to insulin resistance. In these studies, we will focus on the relationship between leptin and diabetes mellitus type 2 and insulin resistance with obesity. In this study, we will focus on the relationship between the leptin hormone and obesity with diabetes. 

Keywords

Leptin, Obesity, Diabetes, Human, Metabolism

References

• [1] Hussain, Z. and Khan, J.A., (2017). Food Intake Regulation by Leptin: Mechanisms Mediating Gluconeogenesis and Energy Expenditure, 10(10):940-944.
• [2] Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M.J.N., (1994). Positional Cloning of the Mouse Obese Gene and Its Human Homologue, 372(6505):425.
• [3] Faust, I.M., Johnson, P.R., and Hirsch, J.J.S., (1977). Adipose Tissue Regeneration Following Lipectomy, 197(4301):391-393.
• [4] Harris, R.B., (1990). Role of Set-Point Theory in Regulation of Body Weight, 4(15):3310-3318.
• [5] Sari, A., (2013). The Relationship Between Leptin and Fatty Acid, 4(139):2.
• [6] Meier, U. and Gressner, A.M., (2004). Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin, 50(9):1511-1525.
• [7] Halaas, J.L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D.A., and Friedman, J.M., (1997). Physiological Response to Long-term Peripheral and Central Leptin Infusion in Lean and Obese Mice, 94(16):8878-8883.
• [8] Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., and Burn, P.J.S., (1995). Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks, 269(5223):546-549.
• [9] Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K., and Friedman, J.M., (1995). Weight-reducing Effects of the Plasma Protein Encoded by the Obese Gene, 269(5223):543-546.
• [10] Spiegelman, B.M. and Flier, J.S., (1996). Adipogenesis and Obesity: Rounding out the Big Picture, 87(3):377-389.
• [11] Flier, J.S., (1998). What’s in a Name? In Search of Leptin’s Physiologic Role, 83(5):1407-1413.
• [12] Friedman, J.M. and Halaas, J.L., (1998). Leptin and the Regulation of Body Weight in Mammals, 395(6704):763.
• [13] Allison, D.B., Fontaine, K.R., Manson, J.E., Stevens, J., and VanItallie, T.B.J.J., (1999). Annual Deaths Attributable to Obesity in the United States, 282(16):1530-1538.
• [14] Mokdad, A.H., Bowman, B.A., Ford, E.S., Vinicor, F., Marks, J.S., and Koplan, J.P., (2001). The Continuing Epidemics of Obesity and Diabetes in the United States, 286(10):1195-1200.
• [15] Nilsson, C., Niklasson, M., Eriksson, E., Björntorp, P., and Holmäng, A.J.T., (1998). Imprinting of Female Offspring with Testosterone Results in Insulin Resistance and Changes in Body Fat Distribution at Adult Age in Rats, 101(1):74-78.
• [16] Krssak, M., Petersen, K.F., Dresner, A., DiPietro, L., Vogel, S., Rothman, D., Shulman, G., and Roden, M.J.D., (1999). Intramyocellular Lipid Concentrations are Correlated with Insulin Sensitivity in Humans: a 1H NMR Spectroscopy Study, 42(1):113-116.
• [17] Diagnosis and Classification of Diabetes Mellitus, (2013). American Diabetes Association, 36(Supplement 1):S67-S74.
• [18] Esteghamati, A., Gouya, M.M., Abbasi, M., Delavari, A., Alikhani, S., Alaedini, F., Safaie, A., Forouzanfar, M., and Gregg, E.W., (2008). Prevalence of Diabetes and Impaired Fasting Glucose in the Adult Population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran, 31(1):96-98.
• [19] Wang, B., Charukeshi C.P., and Pippin, J., (2014). Leptin-and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes, 10(2):131-145.
• [20] Atlas, D.J., (2015). Brussels, Belgium: International Diabetes Federation, International Diabetes Federation. 7th edn.
• [21] Mcneely, M.J., Boyko, E.J., Weigle, D.S., Shofer, J.B., Chessler, S.D., Leonnetti, D.L., and Fujimoto, W.Y., (1999). Association Between Baseline Plasma Leptin Levels and Subsequent Development of Diabetes in Japanese Americans, 22(1):65-70.
• [22] Kahn, S.E., Hull, R.L., and Utzschneider, K.M.J.N., (2006). Mechanisms Linking Obesity to Insulin Resistance and Type 2 Diabetes, 444(7121):840.
• [23] Røder, M.E., Porte Jr, D., Schwartz, R.S., and Kahn, S.E., (1998). Disproportionately Elevated Proinsulin Levels Reflect the Degree of Impaired B Cell Secretory Capacity in Patients with Noninsulin-Dependent Diabetes Mellitus, 83(2):604-608.
• [24] Al-Goblan, A.S., Al-Alfi, M.A., and Khan, M.Z., (2014). Mechanism Linking Diabetes Mellitus and Obesity, 7:587.
• [25] Nutr, A.J.C., (1998). Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults, 6(Suppl 2):51S-209S.
• [26] Morton, G.J. and Schwartz, M.W., (2011). Leptin and the Central Nervous System Control of Glucose Metabolism, 91(2):389-411.
• [27] Dubuc, P.U., (1976). The Development of Obesity, Hyperinsulinemia, and Hyperglycemia in ob/ob Mice, 25(12):1567-1574.
• [28] Wyse, B. and Dulin, W.J.D., (1970). The Influence of Age and Dietary Conditions on Diabetes in the db Mouse, 6(3):268-273.
• [29] Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T., and Collins, F.J.S., (1995). Effects of the Obese Gene Product on Body Weight Regulation in ob/ob Mice, 269(5223):540-543.
• [30] Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S., and Goldstein, J.L., (1999. Leptin Reverses Insulin Resistance and Diabetes Mellitus in Mice with Congenital lipodystrophy, 401(6748):73.
• [31] Petersen, K.F., Oral, E.A., Dufour, S., Befroy, D., Ariyan, C., Yu, C., Cline, G.W., DePaoli, A.M., Taylor, S.I., and Gorden, P.J., (2002). Leptin Reverses Insulin Resistance and Hepatic Steatosis in Patients with Severe Lipodystrophy, 109(10):1345-1350.
• [32] Patni, N. and Garg, A.J., (2015). Congenital Generalized Lipodystrophies—new Insights into Metabolic Dysfunction, 11(9):522.
• [33] Meek, T.H. and Morton, G.J., (2016). The Role of Leptin in Diabetes: Metabolic Effects, 59(5):928-932.
• [34] Fujikawa, T., Chuang, J.-C., Sakata, I., Ramadori, G., and Coppari, R.J., 2010. Leptin Therapy Improves Insulin-Deficient Type 1 Diabetes by CNS-dependent Mechanisms in Mice, 107(40):17391-17396.
• [35] German, J.P., Thaler, J.P., Wisse, B.E., oh-I, S., Sarruf, D.A., Matsen, M.E., Fischer, J.D., Taborsky Jr, G.J., Schwartz, M.W., and Morton, G.J.J.E., (2010). Leptin Activates a Novel CNS Mechanism for Insulin-independent Normalization of Severe Diabetic Hyperglycemia, 152(2):394-404.
• [36] Hidaka, S., Yoshimatsu, H., Kondou, S., Tsuruta, Y., Oka, K., Noguchi, H., Okamoto, K., Sakino, H., Teshima, Y., and Okeda, T.J., (2002). Chronic Central Leptin Infusion Restores Hyperglycemia Independent of Food Intake and Insulin Level in Streptozotocin-Induced Diabetic Rats, 16(6):509-518.
• [37] Lin, C.Y., Higginbotham, D.A., Judd, R.L., and White, B.D., (2002). Central Leptin Increases Insulin Sensitivity in Streptozotocin-induced Diabetic Rats, 282(5):E1084-E1091.
• [38] Wauters, M., Considine, R.V., and Van Gaal, L.F., (2000. Human Leptin: From an Adipocyte Hormone to an Endocrine Mediator, 143(3):293-311.
• [39] Taylor, S.I., Barr, V., and Reitman, M.J.S., (1996). Does Leptin Contribute to Diabetes Caused by Obesity?, 274(5290):1151-1151.
• [40] Zimmet, P. and Alberti, K.J., (1996). Leptin: is it Important in Diabetes?, 13(6):501-503.
• [41] Seufert, J., Kieffer, T.J., Leech, C.A., Holz, G.G., Moritz, W., Ricordi, C., and Habener, J.F., (1999). Leptin Suppression of Insulin Secretion and Gene Expression in Human Pancreatic Islets: Implications for the Development of Adipogenic Diabetes Mellitus, 84(2):670-676.
• [42] Shimabukuro, M., Koyama, K., Chen, G., Wang, M.Y., Trieu, F., Lee, Y., Newgard, C.B., and Unger, R.H., (1997). Direct Antidiabetic Effect of Leptin Through Triglyceride Depletion of Tissues, 94(9), 4637-4641.
• [43] Sarmiento, U., Benson, B., Kaufman, S., Ross, L., Qi, M., Scully, S., and DiPalma, C.J., (1997). Morphologic and Molecular Changes Induced by Recombinant Human Leptin in the White and Brown Adipose Tissues of C57BL/6 Mice, 77(3):243-256.
• [44] Maffei, M., Stoffel, M., Barone, M., Moon, B., Dammerman, M., Ravussin, E., Bogardus, C., Ludwig, D.S., Flier, J.S., and Talley, M.J.D., (1996). Absence of Mutations in the Human OB Gene in Obese/diabetic Subjects, 45(5):679-682.
• [45] Shigemoto, M., Nishi, S., Ogawa, Y., Isse, N., Matsuoka, N., Tanaka, T., Azuma, N., Masuzaki, H., Nishimura, H., and Yoshimasa, Y.J., (1997). Molecular Screening of both the Promoter and the Protein Coding Regions in the Human ob Gene in Japanese Obese Subjects with Non-Insulin-Dependent Diabetes Mellitus, 137(5):511-513.
• [46] Schwartz, M.W., Prigeon, R.L., Kahn, S.E., Nicolson, M., Moore, J., Morawiecki, A., Boyko, E.J., and Porte, D.J., (1997). Evidence that Plasma Leptin and Insulin Levels are Associated with Body Adiposity Via Different Mechanisms, 20(9):1476-1481.
• [47] Haffner, S.M., Stern, M.P., Miettinen, H., Wei, M., and Gingerich, R.L., (1996). Leptin Concentrations in Diabetic and Nondiabetic Mexican-Americans, 45(6):822-824.
• [48] McGregor, G.P., Desaga, J.F., Ehlenz, K., Fischer, A., Heese, F., Hegele, A., Lammer, C., Peiser, C., and Lang, R.J.E., (1996). Radiommunological Measurement of Leptin in Plasma of Obese and Diabetic Human Subjects, 137(4):1501-1504.
• [49] Ford, E.S., Williamson, D.F., and Liu, S.J.A.j.o.e., (1997). Weight change and diabetes incidence: findings from a national cohort of US adults,146(3), 214-222.
• [50] Resnick, H.E., Valsania, P., Halter, J.B., Lin, X.J.J.o.E., and Health, C., (2000). Relation of Weight Gain and Weight Loss on Subsequent Diabetes Risk in Overweight Adults, 54(8):596-602.
• [51] Mokdad, A.H., Ford, E.S., Bowman, B.A., Dietz, W.H., Vinicor, F., Bales, V.S., and Marks, J.S., (2003). Prevalence of Obesity, Diabetes, and Obesity-related Health Risk Factors, 289(1):76-79.
• [52] McCarthy, M.I., (2010). Genomics, Type 2 Diabetes, and Obesity, 363(24):2339-2350.
• [53] Neel, J.V., (1962). Diabetes Mellitus: a “Thrifty” Genotype Rendered Detrimental by “progress”?, 14(4):353.
• [54] Zimmet, P. and Thomas, C.R., (2003). Genotype, Obesity and Cardiovascular Disease–Has Technical and Social Advancement Outstripped Evolution?, 254(2):114-125.
• [55] Lazar, M.A, (2005). How Obesity Causes Diabetes: Not a Tall Tale, 307(5708):373-375.
• [56] Kershaw, E.E. and Flier, J.S., (2004). Adipose Tissue as an Endocrine Organ, 89(6):2548-2556.
• [57] Das, M., Gabriely, I., and Barzilai, N.J., (2004). Caloric Restriction, Body Fat and Ageing in Experimental Models, 5(1):13-19.
• [58] Friedman, J.M., (2002). The Function of Leptin in Nutrition, Weight, and Physiology, 60(suppl_10):S1-S14.
• [59] Bergman, R.N. and Ader, M.J., (2000). Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus, 11(9):351-356.
• [60] Boden, G. and Shulman, G.J., (2002). Free Fatty Acids in Obesity and Type 2 Diabetes: Defining Their Role in the Development of Insulin Resistance and β‐cell Dysfunction, 32:14-23.
• [61] Rajala, M.W. and Scherer, P.E.J.E., (2003). Minireview: the Adipocyte—at the Crossroads of Energy Homeostasis, Inflammation, And Atherosclerosis, 144(9):3765-3773.
• [62] American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care (2005); 28 (Suppl. 1): S37-42.
• [63] Cefalu, W.T., (2001). Insulin Resistance: Cellular and Clinical concepts. Exp Biol Med, 226:13–26.
• [64] Altuntaş, Y., (2000). Tip 2 Diyabetes Mellitus’un Patogenezi. Yenigün M (editör). Her Yönüyle Diabetes Mellitus. 2. baskı, İstanbul: Nobel Tıp Kitabevleri, 219-233.
• [65] Ayvaz, G., (2005). Diabetes Mellitus Patogenezi. İliçin G, Biberoğlu K, Süleymanlar G, Ünal S (Editorler). İç Hastalıkları. 2. baskı, Ankara: Öncü Basımevi, 2295-2298.
• [66] Dagago-Jack, S., Liu, J., Askaria, H., Tykodi, G., and Umamaheswaran I., (2000). Impaired Leptin Tesponse Toglucocorticoid as a Chronic Complication of Diabetes. Journal of Diabetes Complications, 14:327-332.
• [67] Liu, J., Askari, H., and Dagogo-Jack, S., (1999). Basal and Stimulated Plasma Leptin in Diabetic Subjects. Obesity Research, 7:537-544.
• [68] Mantzoros, C.S., Moschos, S., Avramopoulos, I., Kaklamani, V., Liolios, E., Doulgerakis, D.E., et al. (1997). Leptin Concentrations in Relation to Body Mass Index and The Tumor Necrosis Factor- Α System in Humans. J Clin Endocrinol Metab; 82: 3408-3413.
• [69] McGregor, G.P., Desaga, J.F., Ehlenz, K., Fischer, A., Heese, F., Hegele, A., et al. (1996). Radioimmunological Measurement of Leptin in Plasma of Obese and Diabetic Human Subjects. Endocrinology; 137: 1501-1504.
• [70] Aslan, K., Serdar, Z., and Tokullugil, H.A., (2004). Multifonksiyonel Hormon: Leptin. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 30(2):113-118.
• [71] Havel, P.J., Kasim-Karakas, S., Mueller, W., Johnson, P.R., Gingerich, R.L., Stern, J.S., (1996). Relationship of Plasma Leptin to Plasma Insulin and Adiposity in Normal Weight and Overweight Women. Effects of Dietary Fat Content and Sustained Weight Loss. J Clin Endocrinol Metab, 81:4406-4421313.
• [72] Pratley, R.E., Nicolson, M., Bogardus, C., and Ravussin, E., (1996). Effect of Acute Hyperinsulinemia on Plasma Leptin Concentrations in Insulin-Sensitive and Insulin Resistant Pima Indians. J. Clin Endocrinol Metab, 81:4418-4421.
• [73] Dagogo-Jack, S., Fanelli, C., Paramore, D., Brothers, J., and Landt, M., (1996). Plasma Leptin and Insulin Relationships in Obese and Nonobese Humans (abstract). Diabetes, 45:695-698.
• [74] Mantzoros, C., Flier, J.S., Lesem, M.D., Brewerton, T.D., and Jimerson, D.C., (1997). Cerebrospinal Fluid Leptin in Anorexia Nervosa: Correlation with Nutritional Status and Potential Role in Resistance to Weight Gain. J. Clin Endocrinol Metab. 82:1845- 1851.
• [75] Banks, W.A., Coon, A.B., Robinson, S.M., Moinuddin, A., Shultz, J.M., Nakaoke, R., and Morley, J.E., (2004). Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier. Diabetes, 53:1253-1260.
• [76] Khan, C.R., Weir. G.C., King, G.L., Jacobson. A.M., Moses., A.C., and Smith, R.J., (2005). Joslin’s Diabetes Mellitus. 14thed. Boston: Lippincott William and Wilkins, 333-339.