Differansiye Tiroid Karsinomlu Hastalarda Tekrarlayıcı Radyoiyot Tedavisi

Abstract

Keywords

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Differansiye Tiroid Karsinomlu Hastalarda Tekrarlayıcı Radyoiyot Tedavisi

Abstract

Amaç: Diferansiye tiroid karsinomlu (DTK) hastalarda tekrarlanan değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Ameliyat sonrası radyoaktif iyot tedavisi almak üzere refere edilen 945 DTK’lı hasta retrospektif olarak incelendi. Birden fazla 131I ile tedavi alan 77 hasta bu çalışma için seçildi. Bu çalışmada yeniden tedavi alanların endikasyonları ile demografik ve patolojik özellikleri değerlendirildi. Bulgular: Kiniğimizde 945 hastadan 77’si(% 8.1) yeniden tedavi edilmişti. Histolojik incelemeleri sonucunda 69 hastanın papiller tiroid karsinomlu, 8 hastanın ise foliküler tiroid karsinomlu olduğu ortaya kondu. 16 hasta (% 20.8) tamamlayıcı ablasyon için yeniden tedavi edildi. 28 hasta (%36.4) ilk radyoaktif iyot tedavisinden 6 ay sonra stimüle edilmiş Tg düzeylerinin yüksek olması nedeniyle ampirik olarak yeniden tedavi edildi. 29 hasta (% 37.6) uzak metastazları nedeniyle yeniden tedavi edildi. 4 hasta (% 5.2) takipte rekürrens tesbit edimesi üzerine yeniden tedavi edildi. Sonuç: Radyoaktif iyot tedavisi diferansiye tiroid karsinomunda cerrahi sonrası tedavide ana yöntemdir ve başarı oranı yüksektir. Bununla beraber bazı hastalarda, özellikle de metastatik hastalarda, tekrarlayıcı tedavilere ihtiyaç duyulmaktadır. Ayrıca radyoaktif iyot tedavisi diferansiye tiroid karsinomu tedavisinde temel pozisyonunu korumaktadır

Keywords

• Tiroid karsinomu, Iyot-131 tedavisi, Yeniden tedavi

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