Timpanoplasti Sonrası Greft Başarısızlığı ile Sigara Kullanımı ve Preoperatif İnflamatuar Belirteçler Arasındaki İlişkinin Değerlendirilmesi

Abstract

Bu çalışma, farklı tekniklerle timpanoplasti uygulanan hastalarda greft başarısı ile sigara kullanımı durumu ve preoperatif tam kan sayımına (CBC) dayalı inflamatuar belirteçler (CRP, WBC, NLR, PLR, RDW) arasındaki ilişkiyi araştırmayı amaçlamaktadır. Bu retrospektif çalışmaya, 2023 ile 2025 yılları arasında kliniğimizde timpanoplasti ameliyatı geçiren 40 hasta dâhil edilmiştir. Hastalar, greft başarısına göre başarısız ve başarılı olmak üzere iki gruba ayrılmıştır. Sigara içme durumu, cerrahi teknik ve inflamatuar laboratuvar parametreleri kaydedilmiştir. İstatistiksel analizlerde Fisher’s Exact Test, Ki-kare Testi ve Mann–Whitney U Testi kullanılmıştır (p < 0.05 anlamlı kabul edilmiştir). Sigara içme durumu ile greft başarısızlığı arasında istatistiksel olarak anlamlı bir ilişki bulunmuştur (p = 0.001). CRP düzeyleri istatistiksel olarak anlamlı olmamakla birlikte sınırda anlamlılık göstermiştir (p = 0.055). Greft sonuçları ile WBC, NLR, PLR ve RDW gibi diğer inflamatuar belirteçler arasında anlamlı bir ilişki gözlenmemiştir. Uygulanan cerrahi tekniklerin de greft başarısını anlamlı şekilde etkilemediği görülmüştür (p = 0.144). Bu bulgular, greft başarısını artırmak için hastalara ameliyat öncesi sigarayı bırakmalarının önerilmesinin önemini ortaya koymaktadır.

Keywords

• Timpanoplasti
• Greft Sağkalımı
• Sigara Kullanımı
• C-Reaktif Protein
• Biyobelirteçler
• İnflamasyon

Evaluation of the relationship between graft failure after tympanoplasty and smoking status and preoperative inflammatory markers

Abstract

This study aimed to investigate the relationship between graft success in patients undergoing tympanoplasty with various techniques and smoking status, as well as preoperative complete blood count (CBC)-based inflammatory markers (CRP, WBC, NLR, PLR, RDW). This retrospective study included 40 patients who underwent tympanoplasty in our clinic between 2023 and 2025. Patients were divided into two groups based on graft success as not-failed and failed. Smoking status, surgical technique, and inflammatory laboratory parameters were recorded. Fisher’s Exact Test, Chi-square Test, and Mann–Whitney U Test were used for statistical analyses (p < 0.05 was considered significant). A statistically significant association was found between smoking status and graft failure (p = 0.001). CRP levels were not statistically significant (p = 0.055), but showed borderline results. No significant relationship was observed between graft outcomes and other inflammatory markers such as WBC, NLR, PLR, and RDW. Surgical techniques also did not significantly affect graft success (p = 0.144). These findings shows the importance of advising patients to stop smoking before surgery to improve the graft success rates.

Keywords

• Tympanoplasty
• Graft Survival
• Smoking
• C-Reactive Protein
• Biomarkers
• Inflammation

Ethical Statement

This study was approved by the Committee of Ethics (ıBAEK-324) of the Giresun Training and Research Hospital.

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