Diyabetik ve Prediyabetik Hastalarda Osteoprotegerin RANKL ve Karotis İntima Media Kalınlığı

Year 2014, Volume: 1 Issue: 2, 49 - 54, 01.09.2014

Şerife Mehlika Kuşkonmaz Yakup Yeşilkaya Mutlu Hayran Deniz Akata Ömer Alper Gürlek

Abstract

Keywords

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Diyabetik ve Prediyabetik Hastalarda Osteoprotegerin RANKL ve Karotis İntima Media Kalınlığı

Abstract

Amaç: Osteoprotegerin ve RANKL’ın (receptor activator of nuclear factor ĸB) osteoporozdaki rolleri iyi bilinmektedir fakat yakın zamanda ateroskleroz üzerine etkileri araştırılmaya başlanmıştır. Bu çalışma komplikasyonsuz diyabetik ve prediyabetik hastalarda ateroskleroz ile osteoprotegerin RANKL düzeyleri arasında bir ilişki olup olmadığını araştırmaya yöneliktir. Yöntem: Olgular tip 2 diyabet (n:20), bozulmuş glukoz toleransı (BGT) (n:16), bozulmuş açlık glukozu (BAG) (n: 19) ve kontrol grubu (n:23) olarak gruplandı. Osteoprotegerin ve çözünebilir RANKL, ELISA yöntemiyle ölçüldü ve sağ ve sol tarafta karotis intima media kalınlığı (KİMK) ölçülerek ortalama hesaplandı. Bulgular: Diğer gruplarla karşılaştırıldığında diyabetiklerde KİMK daha fazlaydı fakat bu fark istatistiksel olarak anlamlı değildi. Gruplar arasında osteprotegerin ve RANKL düzeyleri açısından fark yoktu. Korelasyon analizi sadece BAG grubunda osteoprotegerin ve KİMK arasında bir pozitif korelasyon (r 0,47) ve kontrol grubunda RANKL ve KİMK arasında bir negatif korelasyon (r -0,45) olduğunu gösterdi. Diyabetik hastalarda osteoprotegerin ve insulin düzeyleri arasında bir pozitif korelasyon (p

Keywords

osteoprotegerin, RANKL, ateroskleroz, diyabet, insülin

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