Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels

Hanife Songül Kaçoğlu; Özgür Ceylan; Mithat Çelebi

doi:10.56171/ojn.1488770

TR EN

Kimyasal Olarak Çapraz Bağlı Gözenekli Kitosan Hidrojellerin Şişme Kinetiği ve Difüzyon Mekanizmalarının Belirlenmesi

Öz

Kitosan hidrojelleri biyouyumlulukları, biyobozunurlukları ve çeşitli fizikokimyasal özelliklerinden dolayı çeşitli endüstriyel uygulamalarda popülerlik kazanmıştır. Bu hidrojellerin şişme dinamiklerini ve difüzyon süreçlerini anlamak, ilaç dağıtımı, doku mühendisliği ve yara iyileşmesindeki etkinliklerinin arttırılması açısından çok önemlidir. Bu çalışma kimyasal olarak çapraz bağlı gözenekli kitosan hidrojellerde şişme ve difüzyon süreçlerini incelemeyi amaçlamaktadır. Hidrojellerin şişme kinetiği, pH: 2.0, pH: 5.6 ve pH: 7.4’ te kitosanın farklı moleküler ağırlıklarının şişme davranışı üzerindeki etkilerini belirlemek için Fick Kanunu difüzyon matematiksel modeli kullanılarak araştırıldı. Glutaraldehid ile çapraz bağlanan kitosan hidrojelleri, Fick'in difüzyon yasalarına göre Süper Durum II Difüzyonu gösterdi.

Anahtar Kelimeler

hidrojel , dondurarak kurutma , Fick Yasası , şişme kinetiği , diffüzyon katsayısı

Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels

Abstract

Chitosan hydrogels have gained popularity in a variety of industrial applications due to their biocompatibility, biodegradability, and varied physicochemical features. Understanding these hydrogels' swelling dynamics and diffusion processes is crucial for improving their efficacy in drug delivery, tissue engineering, and wound healing. This work aims to examine the processes of swelling and diffusion in chemically crosslinked porous chitosan hydrogels. The swelling kinetics of the hydrogels were investigated using Fick's diffusion mathematical model to determine the effects of different molecular weights of chitosan on the swelling behavior at pH: 2.0, pH: 5.6 and pH: 7.4. Chitosan hydrogels cross-linked with glutaraldeyhde showed Super Case II Diffusion according to Fick's laws of diffusion.

Keywords

hydrogel , freeze-drying , Fick’s law , swelling kinetic , diffusion coefﬁcient

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Details

Primary Language

English

Subjects

Biomaterial , Polymer Science and Technologies

Journal Section

Research Article

Authors

Hanife Songül Kaçoğlu
0000-0002-4982-5172
Türkiye

Özgür Ceylan
0000-0003-1265-3730
Türkiye

Mithat Çelebi ^*
0000-0002-2013-5354
Türkiye

Publication Date

December 29, 2024

Submission Date

May 23, 2024

Acceptance Date

July 30, 2024

Published in Issue

Year 2024 Volume: 9 Number: 2

DOI

https://doi.org/10.56171/ojn.1488770

IZ

https://izlik.org/JA66XA87GR

APA

Kaçoğlu, H. S., Ceylan, Ö., & Çelebi, M. (2024). Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels. Open Journal of Nano, 9(2), 106-118. https://doi.org/10.56171/ojn.1488770

AMA

1.Kaçoğlu HS, Ceylan Ö, Çelebi M. Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels. Open J. Nano. 2024;9(2):106-118. doi:10.56171/ojn.1488770

Chicago

Kaçoğlu, Hanife Songül, Özgür Ceylan, and Mithat Çelebi. 2024. “Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels”. Open Journal of Nano 9 (2): 106-18. https://doi.org/10.56171/ojn.1488770.

EndNote

Kaçoğlu HS, Ceylan Ö, Çelebi M (December 1, 2024) Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels. Open Journal of Nano 9 2 106–118.

IEEE

[1]H. S. Kaçoğlu, Ö. Ceylan, and M. Çelebi, “Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels”, Open J. Nano, vol. 9, no. 2, pp. 106–118, Dec. 2024, doi: 10.56171/ojn.1488770.

ISNAD

Kaçoğlu, Hanife Songül - Ceylan, Özgür - Çelebi, Mithat. “Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels”. Open Journal of Nano 9/2 (December 1, 2024): 106-118. https://doi.org/10.56171/ojn.1488770.

JAMA

1.Kaçoğlu HS, Ceylan Ö, Çelebi M. Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels. Open J. Nano. 2024;9:106–118.

MLA

Kaçoğlu, Hanife Songül, et al. “Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels”. Open Journal of Nano, vol. 9, no. 2, Dec. 2024, pp. 106-18, doi:10.56171/ojn.1488770.

Vancouver

1.Hanife Songül Kaçoğlu, Özgür Ceylan, Mithat Çelebi. Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels. Open J. Nano. 2024 Dec. 1;9(2):106-18. doi:10.56171/ojn.1488770

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