Effect of Preemptive Ibuprofen and Dexketoprofen on Postoperative Pain After Septorhinoplasty

Abstract

Objective: Postoperative comfort is as significant as the postoperative results in patients who underwent septorhinoplasty. Intravenous NSAIDs are playing an increasingly large role in analgesia, antiinflammation and antipyresis in the hospitalized setting. The aim of this study is to assess the preemptive analgesic effect of intravenous ibuprofen and dexketoprofen on postoperative pain in patients undergoing septorhinoplasty. Methods: This study was performed with 76 patients who undergoing open septorhinoplasty between 2016 and 2017. The patients were separated into two groups; Group D (n=46) received preemptive intravenous dexketoprofen (50 mg), and Group I (n=30) received preemptive intravenous ibuprofen (800 mg). Pain was assessed at 30th min and 1st, 2nd, 6th,12th and 24th hrs postoperatively using a visual analogue scale (VAS). There was no statistically significant difference between the groups for sex, age, weight, height, ASA class, anesthesia and surgery duration. Results: VAS scores gradually decreased between 30 minutes and 24 hours in both groups and this decrease was statistically significant in both groups (Group D; p <0.001, Group I; p <0.001). The mean VAS scores in the same periods were lower in Group I at all times, but the difference was not statistically significant (p>0.05). Conclusion: This study had indicated that both ibuprofen and dexketoprofen had similar analgesic efficacy. Clinicians can use these two drugs interchangeably by comparing side effects and costs.

Keywords

• Analgesia
• Dexketoprofen
• Ibuprofen
• Pain
• Rhinoplasty

Septorinoplasti Sonrası Preemptif İbuprofen ve Deksketoprofen'in Postoperatif Ağrı Üzerine Etkisi

Abstract

Amaç: Septorinoplasti yapılan hastalarda ameliyat sonrası estetik sonuçlar kadar ameliyat sonrası konfor da önemlidir. İntravenöz NSAID'ler, hastane ortamında analjezi, antiinflamasyon ve antipirezde giderek daha büyük bir rol oynamaktadır. Bu çalışmanın amacı septorinoplasti uygulanan hastalarda intravenöz ibuprofen ve deksketoprofen'in postoperatif ağrı üzerine preempitif analjezik etkisini değerlendirmektir. Gereç ve Yöntemler: Bu çalışmaya 2016-2017 yılları arasında açık septorinoplasti uygulanan 76 hasta dahil edildi. Hastalar; Grup D (n=46) preempitif intravenöz deksketoprofen (50 mg) tedavisi alan ve Grup I (n=30) preempitif intravenöz ibuprofen tedavisi alan (800 mg) olarak iki gruba ayrıldı. Ağrı postoperatif 30. dk ve 1., 2., 6., 12. ve 24. saatlerde görsel analog skala (VAS) ile değerlendirildi. Gruplar arasında yaş, cinsiyet, kilo, boy, ASA sınıfı, anestezi ve ameliyat süresi açısından istatistiksel olarak anlamlı fark yoktu. Bulgular: VAS skorları her iki grupta da 30 dakika ile 24 saat arasında kademeli olarak azaldı ve bu azalma her iki grupta da istatistiksel olarak anlamlıydı (Grup D; p <0.001, Grup I; p <0.001). Aynı dönemlerdeki ortalama VAS skorları Grup I' de her zaman daha düşüktü ancak aradaki fark istatistiksel olarak anlamlı değildi (p>0.05). Sonuç: Bu çalışma, hem ibuprofen hem de deksketoprofen'in benzer analjezik etkinliğe sahip olduğunu göstermiştir. Klinisyenler, yan etkileri ve maliyetleri karşılaştırarak bu iki ilacı birbirinin yerine kullanabilir.

Keywords

• Analjezi
• Deksketoprofen
• İbuprofen
• Ağrı
• Rinoplasti

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