Effects Of Cholecystectomy On Pipid Profile

Abstract

Introduction: Cholecystectomy is widely used to treat gallstone disease as one of the surgical procedures which have been most frequently performed worldwide. The bile acids pool has unchanged size, but it has fast circulation, which causes to expose the enterohepatic organs to increased flux of bile acids per day in cholecystectomized patients. This study aims to evaluate blood lipid levels before and after cholecystectomy. Methods: The total number of 80 consecutive patients underwent elective cholecystectomy were included in this study. Lipid parameters, biochemical analysis were obtained before surgery and after 12 weeks of cholecystectomy. Results: Mean age was 49±13. Sixty (75%) patients were female. None of the subjects died during perioperative course. Levels of total cholesterol (191.9 ±37.1 mg/dl vs. 186.1 ±36.8 mg/dl, respectively; p=0.006), LDL-C (142.6±41.7 mg/dl vs. 133.9±35.1 mg/dl, respectively; p<0.001) were significantly reduced after eight weeks of cholecystectomy, whereas triglyceride and HDL-C levels were not significantly altered. Conclusion: This study demonstrated that cholecystectomy causes a significant reduction of LDL and total cholesterol levels. Prospective randomized studies should help for determining of possible clinical positive effects of cholecystectomy on atherosclerosis.

Keywords

• atherosclerosis
• blood cholesterol
• cholecystectomy
• gallstone

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