The effect of onion juice on menstrual disorder and hormonal parameters in patients with polycystic ovary syndrome

Abstract

Our aim in this study was to objectively observe the effect of onion juice on menstrual disorders (irregular menstruation, dysmenorrhea, amenorrhea, menorrhagia, hypermenorrhea and hypomenorrhea) in patients with polycystic ovary syndrome (PCOS). A method that affects these women's quality of life without side effects has an essential effect on infertility as a global problem.We conducted a prospective randomized analysis of age-matched and body mass index (BMI)-matched women between April 2019 and March 2020. The study population included 64 reproductive-aged women with PCOS. Data collection by questionnaire and blood samples was done before and after 15 days of onion juice use. There was a statistically significant association between before and after onion juice use in terms of High density lipoprotein (HDL), Low density lipoprotein (LDL), and triglyceride (TG) in case group (p<0.05). There was a statistically significant association between before and after onion juice use in terms of irregular menstruation, dysmenorrhea, amenorrhea, and menorrhagia (p<0.05) in case group. According to the findings, menstrual disorders has decreased after 15 days of onion juice use. As a result, onion juice can be used to reduce the complications of PCOS for women. Improvement in dysmenorrhea and amenorrhea has essential effects on the health of women with PCOS.

Keywords

• PCOS
• menstrual disorders
• onion juice

References

1. 1. Alanya Tosun Ş, Gurbuz T, Cebi A, Tosun A, Gokmen O, Usta M. Association of increased levels of omentin‐1 and carotid intima‐media thickness with early signs of cardiovascular risk in patients with polycystic ovary syndrome: A prospective case control study. Journal of Obstetrics and Gynaecology Research. 2022; 48(1): 169-77.
2. 2. Juliawan IMP, Suwana FP, Annas JY, Akbar MF, Widjiati W. High sucrose and cholic acid diet triggers PCOS-like phenotype and reduces enterobacteriaceae colonies in female wistar rats. Pathophysiology. 2022; 29(3): 344-53.
3. 3. Aftab B, Imran M, Shahrukh SI. Effect of Phytoestrogens in the Treatment of Polycystic Ovary Syndrome in Rat Model. Journal of Food and Nutrition Research. 2022; 10(7): 518-25.
4. 4. Madenli AA, İnci Ö, Gürbüz T. The relationship between anti mullerian hormone level and endometrial polyp frequency in patients with polycystic ovary syndrome. Journal of Medicine and Palliative Care.2022; 3(3): 263-7.
5. 5. Gurbuz T, Gungor ND. Understanding the Effects of Obesity over Polycystic Ovary Syndrome by Analyzing Insulin Resistance and Thyroid Hormone in Different BMI Levels. The ulutas medıcal journal. 2021; 7(1):8.
6. 6. Gurbuz T, Gokmen O. A Novel Index to Overcome the Assessment Limitations of Insulin Resistance in Polycystic Ovary Syndrome Homeostatic Model Assessment Index to Red Blood Cell Distribution Width Ratio. Journal of reproductıve medıcıne. 2021; 66(1-2): 9-14.
7. 7. Gürbüz T, Gökmen O, BÖR ED, Uluocak A. Investigating the relationship of serum levels of afamin and interleukin-10 with insulin resistance in infertile women with polycystic ovary syndrome. Journal of Surgery and Medicine. 2021; 5(3): 264-8.
8. 8. Shahid R, Awan KA, Iqbal MJ, Munir H, Saeed I. Diet and lifestyle modifications for effective management of polycystic ovarian syndrome (PCOS). Journal of Food Biochemistry. 2022: e14117.

9. 9. Walker K, Decherney AH, Saunders R. Menstrual dysfunction in PCOS. Clinical Obstetrics and Gynecology. 2021; 64(1): 119-25.
10. 10. Park Y-J, Shin H, Jeon S, Cho I, Park HJ. Development and effects of college-based lifestyle modification program for menstrual health of young adult women with irregular menses: a randomized controlled trial. International journal of environmental research and public health. 2021; 18(1): 233.
11. 11. Kwak Y, Kim Y, Baek KA. Prevalence of irregular menstruation according to socioeconomic status: A population-based nationwide cross-sectional study. PloS one. 2019; 14(3): e0214071.
12. 12. Gurbuz T, Tosun SA, Cebi A, Gokmen O, Usta M. Investigating fetuin-a and paraoxonase-1 activity as markers in polycystic ovary syndrome based on body mass index: a prospective case-control study. Cureus. 2021;13(10): e18553.
13. 13. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism. 2013; 98(12): 4565-92.
14. 14. Vinogradova Y, Coupland C, Hippisley-Cox J. Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. bmj. 2015; 350: h2135.
15. 15. de Bastos M, Stegeman BH, Rosendaal FR, Vlieg AVH, Helmerhorst FM, Stijnen T, et al. Combined oral contraceptives: venous thrombosis. Cochrane Database of Systematic Reviews. 2014(3).
16. 16. Moreno V, Bosch FX, Muñoz N, Meijer CJ, Shah KV, Walboomers JM, et al. Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study. The Lancet. 2002; 359(9312): 1085-92.
17. 17. Gierisch JM, Coeytaux RR, Urrutia RP, Havrilesky LJ, Moorman PG, Lowery WJ, et al. Oral Contraceptive Use and Risk of Breast, Cervical, Colorectal, and Endometrial Cancers: A Systematic ReviewOral Contraceptives and Breast, Cervical, Colorectal, and Endometrial Cancers. Cancer epidemiology, biomarkers & prevention. 2013; 22(11): 1931-43.
18. 18. Morgante G, Massaro M, Di Sabatino A, Cappelli V, De Leo V. Therapeutic approach for metabolic disorders and infertility in women with PCOS. Gynecological Endocrinology. 2018; 34(1): 4-9.
19. 19. Al Basri SF, Al Abdali JA, Alzubaidi HM, Almarhabi AA, Alzubaidi MA, Al Qarni G, et al. Knowledge of Reproductive Age Women About Oral Contraceptive Pills in Al-Qunfudah, Saudi Arabia. Open Access Journal of Contraception. 2022; 13: 61.
20. 20. Ajith DM. Nutritional Management Of Pcos: A Review Article. Journal of Positive School Psychology. 2022; 6(8): 8979-84.
21. 21. Markantes GK, Tsichlia G, Georgopoulos NA. Diet and exercise in the management of PCOS: Starting from the basics. Polycystic Ovary Syndrome: Elsevier; 2022; 97-115.
22. 22. Faul F, Erdfelder E, Buchner A, Lang A-G. Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses. Behavior research methods. 2009; 41(4): 1149-60.
23. 23. Ağar M, Güngör K, Güngör N, Kavrut M, MADENLP A. Vitamin D supplementation inhibits NF-kB signaling pathway in lean and obese women. European Review for Medical and Pharmacological Sciences. 2022; 26: 3973-7.
24. 24. Unnisa H, Annam P, Gubba NC, Begum A, Thatikonda K. Assessment of quality of life and effect of non-pharmacological management in dysmenorrhea. Annals of Medicine and Surgery. 2022; 81:104407.
25. 25. Bajalan Z, Alimoradi Z, Moafi F. Nutrition as a potential factor of primary dysmenorrhea: a systematic review of observational studies. Gynecologic and obstetric investigation. 2019; 84(3): 209-24.
26. 26. Aly JM, Decherney AH. Lifestyle modifications in PCOS. Clinical Obstetrics and Gynecology. 2021; 64(1): 83-9.
27. 27. Arentz S, Smith CA, Abbott J, Bensoussan A. Perceptions and experiences of lifestyle interventions in women with polycystic ovary syndrome (PCOS), as a management strategy for symptoms of PCOS. BMC women's health. 2021; 21(1): 1-8.
28. 28. Krouni A, Forouhari S, Akbarzadeh M, Dabbaghmanesh MH, Jowkar F, Salehi M, et al. Effect of High Fibre, Low Calorie Balanced Diet in Obese Women with Hirsutism: A Randomised Clinical Trail. Journal of Clinical & Diagnostic Research. 2018; 12(6).
29. 29. Hosseini S, Jahromi M, Sayadi M. Effect of vitamin C supplementation on the levels of related hormones in infertile women with polycystic ovary syndrome (PCOS) in Shiraz City. Int J Health Sci. 2014; 2(1): 61-70.
30. 30. Andhalkar S, Chaware V, Redasani V. A review on medicinal plants of natural origin for treatment of polycystic ovarian syndrome (PCOS). Asian Journal of Pharmaceutical Research and Development. 2021; 9(3): 76-81.
31. 31. Wang JG, Anderson RA, Graham III GM, Chu MC, Sauer MV, Guarnaccia MM, et al. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertility and sterility. 2007; 88(1): 240-3.
32. 32. Jelodar G, Masoomi S, Rahmanifar F. Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iranian journal of basic medical sciences. 2018; 21(6): 645.
33. 33. Oboh G, Ademiluyi AO, Agunloye OM, Ademosun AO, Ogunsakin BG. Inhibitory effect of garlic, purple onion, and white onion on key enzymes linked with type 2 diabetes and hypertension. Journal of dietary supplements. 2019; 16(1): 105-18.
34. 34. Zhou N, Zhao Y, Zhang L, Ning Y. Protective effects of black onion polysaccharide on liver and kidney injury in T2DM rats through the synergistic impact of hypolipidemic and antioxidant abilities. International Journal of Biological Macromolecules. 2022.
35. 35. Jayanti NE, Harlina, I’tishom R, editors. An effect of dayak onion (Eleutherine americana Merr) on quality of the sperm. AIP Conference Proceedings; 2019: AIP Publishing LLC.
36. 36. Lee YH, Yang H, Lee SR, Kwon SW, Hong E-J, Lee HW. Welsh onion root (Allium fistulosum) restores ovarian functions from letrozole induced-polycystic ovary syndrome. Nutrients. 2018; 10(10): 1430.