Growth Hormone Variability in Children and Adolescents with Helicobacteriosis

Abstract

To study the level of growth hormone in blood serum in children and adolescents with chronic gastroduodenal pathology (CGDP) against the background of helicobacteriosis. We examined 286 children from 6 to 15 years old with chronic gastroduodenal diseases and 110 healthy children who were included in the control group. The study of the level of growth hormone (GH) was carried out according to a standard method. In children under adolescence with helicobacteriosis, compared with the control group, GH varied from 6.7% to 27.2%, depending on the type of pathology. In adolescents, the level of growth hormone varied from 11.7% to 35.1% (P<0.05), and with peptic ulcer - 35.1% lower than in the control group. At the same time, in patients with inflammatory forms of CGDP, the GH level was higher by 11.7%. Studies have shown that minimal changes are observed in children before adolescence and the maximum - in adolescents, coinciding with the increased physical and sexual development of children. In children and adolescents with CGDP caused by Helicobacter pylori, there is a decrease in growth hormone in the blood serum compared to healthy children. However, the levels remain within the age reference parameters and vary depending on the clinical form of CGDP. The most significant decrease in the level of growth hormone in comparison with it is observed in patients with peptic ulcer and with chronic duodenitis an increase.

Keywords

• gastritis
• gastroduodenitis
• growth hormone
• Helicobacter pylori

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