Dermatoloji Kliniğine Başvuran Hastalarda Tırnak Bulguları ile Kardiyak Morbidite Arasındaki İlişki: Prospektif Bir Çalışma

Abstract

Giriş: Son çalışmalar, tırnak bulgularının altta yatan kardiyovasküler hastalıkların erken göstergeleri olabileceğini göstermektedir. Bu çalışma, belirli tırnak anomalileri ile diyabet mellitus, hipertansiyon, hiperlipidemi, koroner arter hastalığı, kalp yetmezliği ve kapak hastalıkları arasındaki ilişkileri incelemeyi amaçlamıştır. Yöntemler: Altı aylık bir dönemde dermatoloji kliniğine tırnak bozuklukları nedeniyle başvuran 103 hasta prospektif olarak değerlendirildi. Hastaların demografik ve klinik verileri, ayrıntılı fizik muayene bulguları ve tıbbi kayıtların titiz bir şekilde incelenmesiyle toplandı. Kardiyovasküler patolojilerin bağımsız belirleyicilerini saptamak amacıyla lojistik regresyon analizi kullanıldı. Bulgular: Çalışma popülasyonu ortalama 47 ± 7,2 yaşında olup %59 kadın ve %41 erkekten oluşmaktaydı. Terry tırnakları, diyabet mellitus (OR = 5,23; %95 CI: 1,037–26,365, p = 0,045) ve koroner arter hastalığı (OR = 6,25; %95 CI: 1,685–23,168, p = 0,006) ile anlamlı ilişki gösterdi. Muehrcke çizgileri kalp yetmezliği ile (OR = 5,89; %95 CI: 1,663–20,831, p = 0,006) ve kırmızı lunula kapak hastalıkları ile (OR = 4,76; %95 CI: 1,387–16,302; p = 0,013) anlamlı olarak korelasyon gösterdi. Sonuç: Belirli tırnak bozuklukları, altta yatan kardiyovasküler hastalıkların klinik belirteçleri olarak değerlendirilebilir. Dermatolojik değerlendirme, kardiyovasküler morbiditenin erken tespiti ve yönetimine katkıda bulunabilir.

Keywords

• Tırnak Bozuklukları
• Kardiyak Morbidite
• Erken Tanı
• Dermatolojik Değerlendirme
• Kardiyovasküler Hastalıklar

The relationship between nail findings and cardiac morbidity in patients visiting a dermatology clinic: A prospective study

Abstract

Recent research highlights that dermatological manifestations, particularly nail disorders, can serve as clinical indicators of underlying cardiovascular pathologie. This study aimed to elucidate the association between specific nail findings and cardiovascular morbidities, including diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, heart failure, and valvular heart disease. A prospective observational study was conducted involving 103 patients who presented with nail disorders at dermatology clinics within a six-month interval. Data were systematically collected through comprehensive clinical examinations and review of medical records, encompassing demographic and clinical parameters. Logistic regression analysis was utilized to identify independent predictors of cardiovascular outcomes. The study cohort had a mean age of 47 ± 7.2 years, comprising 59% female and 41% male participants. Several nail disorders were identified as significant predictors of cardiovascular pathology. Specifically, the presence of Terry's nails was significantly associated with diabetes mellitus (OR = 5.23; 95% CI: 1.037–26.365, p = 0.045) and coronary artery disease (OR = 6.25; 95% CI: 1.685–23.168, p = 0.006). Muehrcke's lines emerged as significant predictors of heart failure (OR = 5.89; 95% CI: 1.663–20.831, p = 0.006), whereas the identification of red lunula was significantly correlated with valvular heart disease (OR = 4.76; 95% CI: 1.387–16.302, p = 0.013). Distinct nail disorders may serve as valuable clinical markers of underlying cardiovascular diseases. Dermatological assessments could, therefore, contribute to early detection and management of cardiovascular morbidity.

Keywords

• Nail Disorders
• Cardiac Morbidity
• Early Detection
• Dermatological Assessment
• Cardiovascular Disease

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