Postoperative hemodynamic stabilization with terlipressin: A case of liver transplantation

Year 2025, Volume: 42 Issue: 1, 98 - 100, 28.03.2025

Neslihan Ünal Akdemir , Özkul Yılmaz Çolak , Melda İşevi , Tuğçehan Sezer Akman , Fatma Ulger

https://izlik.org/JA63MA96WH

Abstract

This report presents the successful management of a patient with acute liver failure on the background of chronic liver disease who underwent liver transplantation. Terlipressin, a vasoactive agent, managed hepatorenal syndrome and acute kidney injury by promoting splanchnic vasoconstriction and intrahepatic vasodilation, improving renal blood flow and hemodynamic stability. The case involves a 41-year-old woman with autoimmune hepatitis and primary biliary cirrhosis who required triple vasoactive therapy postoperatively. Bolus doses of terlipressin reduced the need for other vasopressors, stabilized renal function, and facilitated her recovery. This case underscores the potential of terlipressin as a valuable therapeutic option in the postoperative management of liver transplantation patients with refractory hemodynamic instability. Careful dosing and monitoring are essential to optimize outcomes and minimize risks.

Keywords

Hepatorenal Syndrome , Liver Transplantation , Terlipressin

Ethical Statement

We confirm that no ethical violations were committed in preparing this case report.

Thanks

We would like to extend our heartfelt gratitude to the Liver Transplant Surgery Team, the Anesthesiology and Reanimation Team, and the Organ Transplant Coordination Unit at Ondokuz Mayıs University for their invaluable support and contributions.

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