Review
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Year 2026, Volume: 43 Issue: 1 , 96 - 103 , 01.04.2026
https://izlik.org/JA66TT75CS

Abstract

References

  • Standring, S. Gray’s Anatomy: The Anatomical Basis of Clinical Practice. 42nd ed. Elsevier, 2021.
  • Moore, K L, Dalley, A F ve Agur, AMR. Clinically Oriented Anatomy. 9th ed. Wolters Kluwer, 2022.
  • Sadler, T W. Langman’s Medical Embryology. 14th ed. Lippincott Williams & Wilkins, 2019.
  • Kaplan KM, Spivak JM, Bendo JA. Embryology of the spine and associated congenital abnormalities. Spine J. 2005 Sep-Oct;5(5):564-76. doi: 10.1016/j.spinee.2004.10.044.
  • Mellado JM, Larrosa R, Martín J, Yanguas N, Solanas S, Cozcolluela MR. MDCT of variations and anomalies of the
  • neural arch and its processes: part 1--pedicles, pars interarticularis, laminae, and spinous process. AJR Am J Roentgenol. 2011 Jul;197(1):W104-13. doi: 10.2214/AJR.10.5803.
  • Grimme JD, Castillo M. Congenital anomalies of the spine. Neuroimaging Clin N Am. 2007 Feb;17(1):1-16. doi: 10.1016/j.nic.2006.11.002.
  • Ward L, Evans SE, Stern CD. A resegmentation-shift model for vertebral patterning. J Anat. 2017 Feb;230(2):290- 296. doi: 10.1111/joa.12540. Epub 2016 Sep 1.
  • Christ B, Brand-Saberi B. Limb muscle development. Int J Dev Biol. 2002;46(7):905-14.
  • Moore, K L, Persaud, T V ve Torchia, M G. The Developing Human: Clinically Oriented Embryology. 10th ed. Elsevier, 2016.
  • Mekonen HK, Hikspoors JPJM, Mommen G, Kruepunga N, Köhler SE, Lamers WH. Closure of the vertebral canal in human embryos and fetuses. J Anat. 2017 Aug;231(2):260-274. doi: 10.1111/joa.12638. Epub 2017 Jun 5.
  • Greene ND, Copp AJ. Neural tube defects. Annu Rev Neurosci. 2014;37:221-42. doi: 10.1146/annurev-neuro-062012- 170354.
  • Copp AJ, Stanier P, Greene ND. Neural tube defects: recent advances, unsolved questions, and controversies. Lancet Neurol. 2013 Aug;12(8):799-810. doi: 10.1016/S1474-4422(13)70110-8.
  • Tortori-Donati P, Rossi A, Cama A. Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology. 2000 Jul;42(7):471-91. doi: 10.1007/s002340000325.
  • Lemire RJ. Neural tube defects. JAMA. 1988 Jan 22-29;259(4):558-62.
  • Alvis-Miranda HR, Bula-Anichiarico DA, Calderón-Miranda WG, Moscote-Salazar LR. Iniencephaly: Case Report. J Pediatr Neurosci. 2015 Apr-Jun;10(2):181-4. doi: 10.4103/1817-1745.159211.
  • Xu R, Burgar A, Ebraheim NA, Yeasting RA. The quantitative anatomy of the laminas of the spine. Spine (Phila Pa 1976). 1999 Jan 15;24(2):107-13. doi: 10.1097/00007632-199901150-00002.
  • Tan SH, Teo EC, Chua HC. Quantitative three-dimensional anatomy of cervical, thoracic and lumbar vertebrae of Chinese Singaporeans. Eur Spine J. 2004 Mar;13(2):137-46. doi: 10.1007/s00586-003-0586-z.
  • Raveendranath V, Kavitha T, Umamageswari A. Morphometry of the Uncinate Process, Vertebral Body, and Lamina of the C3-7 Vertebrae Relevant to Cervical Spine Surgery. Neurospine. 2019 Dec;16(4):748-755. doi: 10.14245/ns.1836272.136.
  • Kim S, Kwak DS, Kim IB. Morphometric Analysis and Classification of the Cross-Sectional Shape of the C2 Lamina. Biomed Res Int. 2017;2017:7276946. doi: 10.1155/2017/7276946.
  • Sakci Z, Onen MR, Yuce M, Dereli SS, Naderi S. Lamina Measurements with Computed Tomography for C2 Translaminar Screw Fixation in Pediatric and Adult Cases. Turk Neurosurg. 2021;31(3):460-465. doi: 10.5137/1019- 5149.JTN.32230-20.2.
  • Müller J, Müller JU, Koppe T, Nowak S, Schroeder HWS, Baldauf J. A radiological and anatomic examination of intralaminar screws in the thoracic spine-a theoretical feasibility study. Acta Neurochir (Wien). 2018 Nov;160(11):2229-2236. doi: 10.1007/s00701-018-3678-6.
  • Tyagi, Sonu & Narayan, Ravi. Study of the morphometric variations of the neural arch in the lumbar vertebrae in adult human skeleton of North Indian population. International Journal of Orthopaedics Sciences. 2018; 4: 806- 809. 10.22271/ortho.2018.v4.i1l.117.
  • Masharawi Y, Salame K. Shape variation of the neural arch in the thoracic and lumbar spine: characterization and relationship with the vertebral body shape. Clin Anat. 2011 Oct;24(7):858-67. doi: 10.1002/ca.21175.
  • Kömürcü E, Kaymaz B, Adam G, Gölge UH, Göksel F, Özden R. Safety and feasibility of lumbar spine for intralaminar screw fixation: a computed tomography-based morphometric study. Acta Orthop Traumatol Turc. 2015;49(5):522-9. doi: 10.3944/AOTT.2015.14.0201.
  • Farooqi RR, Mehmood M, Kotwal HA. Hyperplasia of Lamina and Spinous Process of C5 Vertebrae and Associated Hemivertebra at C4 Level. J Orthop Case Rep. 2017 Jan-Feb;7(1):79-81. doi: 10.13107/jocr.2250-0685.698.
  • Esposito G, de Bonis P, Tamburrini G, Massimi L, Byvaltsev V, di Rocco C, Leone A. Unilateral hyperplasia of the left posterior arch and associated vertebral schisis at C6 level. Skeletal Radiol. 2009 Dec;38(12):1191-5. doi: 10.1007/s00256-009-0765-z.
  • Manenti G, Iundusi R, Picchi E, Marsico S, D'Onofrio A, Rossi G, Tarantino U, Floris R. Anatomical variation: T1 spina bifida occulta. Radiological findings. Radiol Case Rep. 2016 Dec 27;12(1):207-209. doi: 10.1016/j.radcr.2016.11.003.
  • K S S, Naduvanahalli Vivekanandaswamy A, Shetty AP, Kanna RM, Rajasekaran S. Progressive hemiparesis due to spino-laminar anomaly of the axis-a case report and literature review. Spinal Cord Ser Cases. 2019 Jul 31;5:69. doi: 10.1038/s41394-019-0214-8.
  • Xu JX, Wang CG, Zhou CW, Tang Q, Li JW, Xu HZ, Mao FM, Tian NF. Cervical myelopathy caused by invaginated laminae of the axis associated with occipitalizaion of the atlas: Case report and literature review. Medicine (Baltimore). 2017 Dec;96(51):e9156. doi: 10.1097/MD.0000000000009156.
  • Sakaura H, Yasui Y, Miwa T, Yamashita T, Ohzono K, Ohwada T. Cervical myelopathy caused by invagination of anomalous lamina of the axis. J Neurosurg Spine. 2013 Dec;19(6):694-6. doi: 10.3171/2013.8.SPINE13325.
  • Wick LF, Kaim A, Bongartz G. Retroisthmic cleft: a stress fracture of the lamina. Skeletal Radiol. 2000 Mar;29(3):162- 4. doi: 10.1007/s002560050586.
  • Sakai T, Sairyo K, Takao S, Kosaka H, Yasui N. Adolescents with symptomatic laminolysis: report of two cases. J Orthop Traumatol. 2010 Sep;11(3):189-93. doi: 10.1007/s10195-010-0101-3.
  • Samadian M, Hosseinzadeh Bakhtevari M, Jahangiri Babadi A, Nabizadeh N, Rezaei O. Congenital Posterior Spinal Agenesis Leads to L2-L3 Instability: a Case Report and Review of the Literature. Arch Iran Med. 2015 Dec;18(12):861- 4.
  • Abera Z, Girma A, Bekele A, Oumer M. Assessment of Morphological and Morphometrical Variations of Sacral Hiatus in Dry Human Sacrum in Ethiopia. Local Reg Anesth. 2021 Feb 24;14:25-32. doi: 10.2147/LRA.S277556.
  • Bagoji IB, Bharatha A, Prakash KG, Hadimani GA, Desai V, Bulgoud RS. A Morphometric and Radiological Study of Sacral Hiatus in Human Adult Sacra and Its Clinical Relevance in Caudal Epidural Anaesthesia. Maedica (Bucur). 2020 Dec;15(4):468-476. doi: 10.26574/maedica.2020.15.4.468.
  • Kilicaslan A, Keskin F, Babaoglu O, Gok F, Erdi MF, Kaya B, Ozbiner H, Ozbek O, Koc O, Kacira BK. Morphometric Analysis of the Sacral Canal and Hiatus Using Multidetector Computed Tomography for Interventional Procedures. Turk Neurosurg. 2015;25(4):566-73. doi: 10.5137/1019-5149.JTN.10942-14.0.
  • Yang X, Luo Q, Li ZQ, Zhang N, Chen XY, Zhou Y, Deng HL, Jiang J, Liu JM. Using the lamina nutrient foramen as the entry point for posterior cervical pedicle screw placement. Clin Neurol Neurosurg. 2021 Aug;207:106711. doi: 10.1016/j.clineuro.2021.106711.
  • Hofler RC, Heiferman DM, Molefe A, LeDuc R, Johans SJ, Rosenblum JD, Nockels RP, Jones GA. Morphologic variations of the second cervical vertebra in Down syndrome compared with age-matched peers. J Neurosurg Spine. 2018 Nov 23;30(2):175-181. doi: 10.3171/2018.8.SPINE18750.
  • Li, K., Yang, Y., Wang, P. et al. Exploring the micromorphological characteristics of adult lower cervical vertebrae based on micro-computed tomography. Sci Rep. 2023; 13, 12400. https://doi.org/10.1038/s41598-023-39703-4
  • Plomp, K.A., Dobney, K., Weston, D.A. et al. 3D shape analyses of extant primate and fossil hominin vertebrae support the ancestral shape hypothesis for intervertebral disc herniation. BMC Evol Biol. 2019; 19, 226.. https://doi.org/10.1186/s12862-019-1550-9.
  • Helms CA, Vogler JB 3rd, Hardy DC. CT of the lumbar spine: normal variants and pitfalls. Radiographics. 1987 May;7(3):447-63. doi: 10.1148/radiographics.7.3.3448643.
  • Carr RB, Fink KR, Gross JA. Imaging of trauma: Part 1, Pseudotrauma of the spine--osseous variants that may simulate injury. AJR Am J Roentgenol. 2012 Dec;199(6):1200-6. doi: 10.2214/AJR.12.9083.
  • Chaturvedi A, Klionsky NB, Nadarajah U, Chaturvedi A, Meyers SP. Malformed vertebrae: a clinical and imaging review. Insights Imaging. 2018 Jun;9(3):343-355. doi: 10.1007/s13244-018-0598-1.
  • Misbah I, Ravula P, Raja S, Mohanakrishnan A, Natarajan P, Gunasekaran D. Comprehensive Radiological Imaging for the Characterization of Spinal Dysraphism and Associated Anomalies in a Pediatric Case. Cureus. 2024 Sep 1;16(9):e68415. doi: 10.7759/cureus.68415.
  • Walocha JA, Rutowicz B, Brzegowy-Solewska K, Lusina D, Skrzat J. Morphological and morphometric analysis of the
  • Sacral Hiatus using lumbosacral spine CT scans: clinical relevance in Caudal Epidural Analgesia. Folia Morphol (Warsz). 2024 Aug 28. doi: 10.5603/fm.101363.
  • Yue J, Han Q, Chen H, Zhang A, Liu Y, Gong X, Wang Y, Wang J, Wu M. Artificial lamina after laminectomy: Progress, applications, and future perspectives. Front Surg. 2023 Feb 2;10:1019410. doi: 10.3389/fsurg.2023.1019410.
  • Montanari, S., Barbanti Bròdano, G., Serchi, E. et al. Experimental ex vivo characterization of the biomechanical effects of laminectomy and posterior fixation of the lumbo-sacral spine. Sci Rep. 2024 14, 30001. https://doi.org/10.1038/s41598-024-80741-3.
  • Yun DJ, Hwang BW, Kim DJ, Lee SH. An Upper and Middle Cervical Spine Posterior Arch Defect Leading to Myelopathy and a Thoracic Spine Posterior Arch Defect. World Neurosurg. 2016 Sep;93:489.e1-5. doi: 10.1016/j.wneu.2016.06.088.
  • Jin L, Yin Y, Chen W, Zhang R, Guo J, Tao S, Guo Z, Hou Z, Zhang Y. Role of the Lumbosacral Transition Vertebra and Vertebral Lamina in the Pathogenesis of Lumbar Disc Herniation. Orthop Surg. 2021 Dec;13(8):2355-2362. doi: 10.1111/os.13122.
  • Tao S, Jin L, Hou Z, Zhang W, Chen T, Zhang Y. A New radiographic feature of lower lumbar disc herniation in young patients. Int Orthop. 2018 Mar;42(3):583-586. doi: 10.1007/s00264-017-3723-8.
  • Kitab SA, Alsulaiman AM, Benzel EC. Anatomic radiological variations in developmental lumbar spinal stenosis: a prospective, control-matched comparative analysis. Spine J. 2014 May 1;14(5):808-15. doi: 10.1016/j.spinee.2013.09.012.

Morphological variations of the vertebral lamina: An anatomical and clinical review

Year 2026, Volume: 43 Issue: 1 , 96 - 103 , 01.04.2026
https://izlik.org/JA66TT75CS

Abstract

The vertebral laminae form the posterior component of the vertebral arch and exhibit considerable morphological variability. Understanding these variations is essential due to their clinical and surgical implications. This review summarizes the types of vertebral lamina variations, the role of imaging in their recognition, and their clinical relevance in surgery, anesthesia, trauma, neurological disorders and congenital anomalies. A literature-based narrative review was conducted focusing on studies describing laminar morphometry, congenital anomalies, imaging characteristics, and clinical outcomes. Variations include hypoplasia, aplasia, asymmetry, and non-fusion, often observed in the cervical and lumbosacral regions. Radiography provides limited detection, whereas CT offers precise morphometric data and MRI demonstrates relationships with neural structures. Clinically, laminar variations affect surgical procedures such as laminectomy and laminoplasty, influence the success of caudal epidural anesthesia, contribute to atypical fracture patterns, and are associated with anomalies such as spina bifida occulta, tethered cord, and neurological disorders including lumbar disc herniation. Vertebral lamina variations are common and clinically significant. Accurate recognition through imaging and awareness of their surgical and anesthetic implications are essential to reduce complications and improve patient outcomes.

References

  • Standring, S. Gray’s Anatomy: The Anatomical Basis of Clinical Practice. 42nd ed. Elsevier, 2021.
  • Moore, K L, Dalley, A F ve Agur, AMR. Clinically Oriented Anatomy. 9th ed. Wolters Kluwer, 2022.
  • Sadler, T W. Langman’s Medical Embryology. 14th ed. Lippincott Williams & Wilkins, 2019.
  • Kaplan KM, Spivak JM, Bendo JA. Embryology of the spine and associated congenital abnormalities. Spine J. 2005 Sep-Oct;5(5):564-76. doi: 10.1016/j.spinee.2004.10.044.
  • Mellado JM, Larrosa R, Martín J, Yanguas N, Solanas S, Cozcolluela MR. MDCT of variations and anomalies of the
  • neural arch and its processes: part 1--pedicles, pars interarticularis, laminae, and spinous process. AJR Am J Roentgenol. 2011 Jul;197(1):W104-13. doi: 10.2214/AJR.10.5803.
  • Grimme JD, Castillo M. Congenital anomalies of the spine. Neuroimaging Clin N Am. 2007 Feb;17(1):1-16. doi: 10.1016/j.nic.2006.11.002.
  • Ward L, Evans SE, Stern CD. A resegmentation-shift model for vertebral patterning. J Anat. 2017 Feb;230(2):290- 296. doi: 10.1111/joa.12540. Epub 2016 Sep 1.
  • Christ B, Brand-Saberi B. Limb muscle development. Int J Dev Biol. 2002;46(7):905-14.
  • Moore, K L, Persaud, T V ve Torchia, M G. The Developing Human: Clinically Oriented Embryology. 10th ed. Elsevier, 2016.
  • Mekonen HK, Hikspoors JPJM, Mommen G, Kruepunga N, Köhler SE, Lamers WH. Closure of the vertebral canal in human embryos and fetuses. J Anat. 2017 Aug;231(2):260-274. doi: 10.1111/joa.12638. Epub 2017 Jun 5.
  • Greene ND, Copp AJ. Neural tube defects. Annu Rev Neurosci. 2014;37:221-42. doi: 10.1146/annurev-neuro-062012- 170354.
  • Copp AJ, Stanier P, Greene ND. Neural tube defects: recent advances, unsolved questions, and controversies. Lancet Neurol. 2013 Aug;12(8):799-810. doi: 10.1016/S1474-4422(13)70110-8.
  • Tortori-Donati P, Rossi A, Cama A. Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology. 2000 Jul;42(7):471-91. doi: 10.1007/s002340000325.
  • Lemire RJ. Neural tube defects. JAMA. 1988 Jan 22-29;259(4):558-62.
  • Alvis-Miranda HR, Bula-Anichiarico DA, Calderón-Miranda WG, Moscote-Salazar LR. Iniencephaly: Case Report. J Pediatr Neurosci. 2015 Apr-Jun;10(2):181-4. doi: 10.4103/1817-1745.159211.
  • Xu R, Burgar A, Ebraheim NA, Yeasting RA. The quantitative anatomy of the laminas of the spine. Spine (Phila Pa 1976). 1999 Jan 15;24(2):107-13. doi: 10.1097/00007632-199901150-00002.
  • Tan SH, Teo EC, Chua HC. Quantitative three-dimensional anatomy of cervical, thoracic and lumbar vertebrae of Chinese Singaporeans. Eur Spine J. 2004 Mar;13(2):137-46. doi: 10.1007/s00586-003-0586-z.
  • Raveendranath V, Kavitha T, Umamageswari A. Morphometry of the Uncinate Process, Vertebral Body, and Lamina of the C3-7 Vertebrae Relevant to Cervical Spine Surgery. Neurospine. 2019 Dec;16(4):748-755. doi: 10.14245/ns.1836272.136.
  • Kim S, Kwak DS, Kim IB. Morphometric Analysis and Classification of the Cross-Sectional Shape of the C2 Lamina. Biomed Res Int. 2017;2017:7276946. doi: 10.1155/2017/7276946.
  • Sakci Z, Onen MR, Yuce M, Dereli SS, Naderi S. Lamina Measurements with Computed Tomography for C2 Translaminar Screw Fixation in Pediatric and Adult Cases. Turk Neurosurg. 2021;31(3):460-465. doi: 10.5137/1019- 5149.JTN.32230-20.2.
  • Müller J, Müller JU, Koppe T, Nowak S, Schroeder HWS, Baldauf J. A radiological and anatomic examination of intralaminar screws in the thoracic spine-a theoretical feasibility study. Acta Neurochir (Wien). 2018 Nov;160(11):2229-2236. doi: 10.1007/s00701-018-3678-6.
  • Tyagi, Sonu & Narayan, Ravi. Study of the morphometric variations of the neural arch in the lumbar vertebrae in adult human skeleton of North Indian population. International Journal of Orthopaedics Sciences. 2018; 4: 806- 809. 10.22271/ortho.2018.v4.i1l.117.
  • Masharawi Y, Salame K. Shape variation of the neural arch in the thoracic and lumbar spine: characterization and relationship with the vertebral body shape. Clin Anat. 2011 Oct;24(7):858-67. doi: 10.1002/ca.21175.
  • Kömürcü E, Kaymaz B, Adam G, Gölge UH, Göksel F, Özden R. Safety and feasibility of lumbar spine for intralaminar screw fixation: a computed tomography-based morphometric study. Acta Orthop Traumatol Turc. 2015;49(5):522-9. doi: 10.3944/AOTT.2015.14.0201.
  • Farooqi RR, Mehmood M, Kotwal HA. Hyperplasia of Lamina and Spinous Process of C5 Vertebrae and Associated Hemivertebra at C4 Level. J Orthop Case Rep. 2017 Jan-Feb;7(1):79-81. doi: 10.13107/jocr.2250-0685.698.
  • Esposito G, de Bonis P, Tamburrini G, Massimi L, Byvaltsev V, di Rocco C, Leone A. Unilateral hyperplasia of the left posterior arch and associated vertebral schisis at C6 level. Skeletal Radiol. 2009 Dec;38(12):1191-5. doi: 10.1007/s00256-009-0765-z.
  • Manenti G, Iundusi R, Picchi E, Marsico S, D'Onofrio A, Rossi G, Tarantino U, Floris R. Anatomical variation: T1 spina bifida occulta. Radiological findings. Radiol Case Rep. 2016 Dec 27;12(1):207-209. doi: 10.1016/j.radcr.2016.11.003.
  • K S S, Naduvanahalli Vivekanandaswamy A, Shetty AP, Kanna RM, Rajasekaran S. Progressive hemiparesis due to spino-laminar anomaly of the axis-a case report and literature review. Spinal Cord Ser Cases. 2019 Jul 31;5:69. doi: 10.1038/s41394-019-0214-8.
  • Xu JX, Wang CG, Zhou CW, Tang Q, Li JW, Xu HZ, Mao FM, Tian NF. Cervical myelopathy caused by invaginated laminae of the axis associated with occipitalizaion of the atlas: Case report and literature review. Medicine (Baltimore). 2017 Dec;96(51):e9156. doi: 10.1097/MD.0000000000009156.
  • Sakaura H, Yasui Y, Miwa T, Yamashita T, Ohzono K, Ohwada T. Cervical myelopathy caused by invagination of anomalous lamina of the axis. J Neurosurg Spine. 2013 Dec;19(6):694-6. doi: 10.3171/2013.8.SPINE13325.
  • Wick LF, Kaim A, Bongartz G. Retroisthmic cleft: a stress fracture of the lamina. Skeletal Radiol. 2000 Mar;29(3):162- 4. doi: 10.1007/s002560050586.
  • Sakai T, Sairyo K, Takao S, Kosaka H, Yasui N. Adolescents with symptomatic laminolysis: report of two cases. J Orthop Traumatol. 2010 Sep;11(3):189-93. doi: 10.1007/s10195-010-0101-3.
  • Samadian M, Hosseinzadeh Bakhtevari M, Jahangiri Babadi A, Nabizadeh N, Rezaei O. Congenital Posterior Spinal Agenesis Leads to L2-L3 Instability: a Case Report and Review of the Literature. Arch Iran Med. 2015 Dec;18(12):861- 4.
  • Abera Z, Girma A, Bekele A, Oumer M. Assessment of Morphological and Morphometrical Variations of Sacral Hiatus in Dry Human Sacrum in Ethiopia. Local Reg Anesth. 2021 Feb 24;14:25-32. doi: 10.2147/LRA.S277556.
  • Bagoji IB, Bharatha A, Prakash KG, Hadimani GA, Desai V, Bulgoud RS. A Morphometric and Radiological Study of Sacral Hiatus in Human Adult Sacra and Its Clinical Relevance in Caudal Epidural Anaesthesia. Maedica (Bucur). 2020 Dec;15(4):468-476. doi: 10.26574/maedica.2020.15.4.468.
  • Kilicaslan A, Keskin F, Babaoglu O, Gok F, Erdi MF, Kaya B, Ozbiner H, Ozbek O, Koc O, Kacira BK. Morphometric Analysis of the Sacral Canal and Hiatus Using Multidetector Computed Tomography for Interventional Procedures. Turk Neurosurg. 2015;25(4):566-73. doi: 10.5137/1019-5149.JTN.10942-14.0.
  • Yang X, Luo Q, Li ZQ, Zhang N, Chen XY, Zhou Y, Deng HL, Jiang J, Liu JM. Using the lamina nutrient foramen as the entry point for posterior cervical pedicle screw placement. Clin Neurol Neurosurg. 2021 Aug;207:106711. doi: 10.1016/j.clineuro.2021.106711.
  • Hofler RC, Heiferman DM, Molefe A, LeDuc R, Johans SJ, Rosenblum JD, Nockels RP, Jones GA. Morphologic variations of the second cervical vertebra in Down syndrome compared with age-matched peers. J Neurosurg Spine. 2018 Nov 23;30(2):175-181. doi: 10.3171/2018.8.SPINE18750.
  • Li, K., Yang, Y., Wang, P. et al. Exploring the micromorphological characteristics of adult lower cervical vertebrae based on micro-computed tomography. Sci Rep. 2023; 13, 12400. https://doi.org/10.1038/s41598-023-39703-4
  • Plomp, K.A., Dobney, K., Weston, D.A. et al. 3D shape analyses of extant primate and fossil hominin vertebrae support the ancestral shape hypothesis for intervertebral disc herniation. BMC Evol Biol. 2019; 19, 226.. https://doi.org/10.1186/s12862-019-1550-9.
  • Helms CA, Vogler JB 3rd, Hardy DC. CT of the lumbar spine: normal variants and pitfalls. Radiographics. 1987 May;7(3):447-63. doi: 10.1148/radiographics.7.3.3448643.
  • Carr RB, Fink KR, Gross JA. Imaging of trauma: Part 1, Pseudotrauma of the spine--osseous variants that may simulate injury. AJR Am J Roentgenol. 2012 Dec;199(6):1200-6. doi: 10.2214/AJR.12.9083.
  • Chaturvedi A, Klionsky NB, Nadarajah U, Chaturvedi A, Meyers SP. Malformed vertebrae: a clinical and imaging review. Insights Imaging. 2018 Jun;9(3):343-355. doi: 10.1007/s13244-018-0598-1.
  • Misbah I, Ravula P, Raja S, Mohanakrishnan A, Natarajan P, Gunasekaran D. Comprehensive Radiological Imaging for the Characterization of Spinal Dysraphism and Associated Anomalies in a Pediatric Case. Cureus. 2024 Sep 1;16(9):e68415. doi: 10.7759/cureus.68415.
  • Walocha JA, Rutowicz B, Brzegowy-Solewska K, Lusina D, Skrzat J. Morphological and morphometric analysis of the
  • Sacral Hiatus using lumbosacral spine CT scans: clinical relevance in Caudal Epidural Analgesia. Folia Morphol (Warsz). 2024 Aug 28. doi: 10.5603/fm.101363.
  • Yue J, Han Q, Chen H, Zhang A, Liu Y, Gong X, Wang Y, Wang J, Wu M. Artificial lamina after laminectomy: Progress, applications, and future perspectives. Front Surg. 2023 Feb 2;10:1019410. doi: 10.3389/fsurg.2023.1019410.
  • Montanari, S., Barbanti Bròdano, G., Serchi, E. et al. Experimental ex vivo characterization of the biomechanical effects of laminectomy and posterior fixation of the lumbo-sacral spine. Sci Rep. 2024 14, 30001. https://doi.org/10.1038/s41598-024-80741-3.
  • Yun DJ, Hwang BW, Kim DJ, Lee SH. An Upper and Middle Cervical Spine Posterior Arch Defect Leading to Myelopathy and a Thoracic Spine Posterior Arch Defect. World Neurosurg. 2016 Sep;93:489.e1-5. doi: 10.1016/j.wneu.2016.06.088.
  • Jin L, Yin Y, Chen W, Zhang R, Guo J, Tao S, Guo Z, Hou Z, Zhang Y. Role of the Lumbosacral Transition Vertebra and Vertebral Lamina in the Pathogenesis of Lumbar Disc Herniation. Orthop Surg. 2021 Dec;13(8):2355-2362. doi: 10.1111/os.13122.
  • Tao S, Jin L, Hou Z, Zhang W, Chen T, Zhang Y. A New radiographic feature of lower lumbar disc herniation in young patients. Int Orthop. 2018 Mar;42(3):583-586. doi: 10.1007/s00264-017-3723-8.
  • Kitab SA, Alsulaiman AM, Benzel EC. Anatomic radiological variations in developmental lumbar spinal stenosis: a prospective, control-matched comparative analysis. Spine J. 2014 May 1;14(5):808-15. doi: 10.1016/j.spinee.2013.09.012.
There are 53 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Review
Authors

Mennan Ece Pirzirenli 0000-0003-0540-3485

Sena Kamalı 0000-0001-9513-8755

Büşra Nur Özcan 0000-0002-1160-4542

Submission Date November 7, 2025
Acceptance Date March 17, 2026
Publication Date April 1, 2026
IZ https://izlik.org/JA66TT75CS
Published in Issue Year 2026 Volume: 43 Issue: 1

Cite

APA Pirzirenli, M. E., Kamalı, S., & Özcan, B. N. (2026). Morphological variations of the vertebral lamina: An anatomical and clinical review. Deneysel Ve Klinik Tıp Dergisi, 43(1), 96-103. https://izlik.org/JA66TT75CS
AMA 1.Pirzirenli ME, Kamalı S, Özcan BN. Morphological variations of the vertebral lamina: An anatomical and clinical review. J. Exp. Clin. Med. 2026;43(1):96-103. https://izlik.org/JA66TT75CS
Chicago Pirzirenli, Mennan Ece, Sena Kamalı, and Büşra Nur Özcan. 2026. “Morphological Variations of the Vertebral Lamina: An Anatomical and Clinical Review”. Deneysel Ve Klinik Tıp Dergisi 43 (1): 96-103. https://izlik.org/JA66TT75CS.
EndNote Pirzirenli ME, Kamalı S, Özcan BN (April 1, 2026) Morphological variations of the vertebral lamina: An anatomical and clinical review. Deneysel ve Klinik Tıp Dergisi 43 1 96–103.
IEEE [1]M. E. Pirzirenli, S. Kamalı, and B. N. Özcan, “Morphological variations of the vertebral lamina: An anatomical and clinical review”, J. Exp. Clin. Med., vol. 43, no. 1, pp. 96–103, Apr. 2026, [Online]. Available: https://izlik.org/JA66TT75CS
ISNAD Pirzirenli, Mennan Ece - Kamalı, Sena - Özcan, Büşra Nur. “Morphological Variations of the Vertebral Lamina: An Anatomical and Clinical Review”. Deneysel ve Klinik Tıp Dergisi 43/1 (April 1, 2026): 96-103. https://izlik.org/JA66TT75CS.
JAMA 1.Pirzirenli ME, Kamalı S, Özcan BN. Morphological variations of the vertebral lamina: An anatomical and clinical review. J. Exp. Clin. Med. 2026;43:96–103.
MLA Pirzirenli, Mennan Ece, et al. “Morphological Variations of the Vertebral Lamina: An Anatomical and Clinical Review”. Deneysel Ve Klinik Tıp Dergisi, vol. 43, no. 1, Apr. 2026, pp. 96-103, https://izlik.org/JA66TT75CS.
Vancouver 1.Mennan Ece Pirzirenli, Sena Kamalı, Büşra Nur Özcan. Morphological variations of the vertebral lamina: An anatomical and clinical review. J. Exp. Clin. Med. [Internet]. 2026 Apr. 1;43(1):96-103. Available from: https://izlik.org/JA66TT75CS