Talamus’un Anatomik Ve Fonksiyonel Önemi

Abstract

Anatomic and Functional Importance of Thalamus Thalamus is the grey material substance which has important roles either in transmitting several senses to the primer sense center in cerebral cortex or in transmitting the informations which come from cerebellum and basal ganglions to the motor zone of cerebral cortex. Thalamus has nucleuses which are responsible of the functions. These nucleuses are also in relation with the central nerve system. Roles of thalamus in neurologic diseases such as dementia, epilepsy, multiple sclerosis and migraine have been demonstrated in several studies. Therefore thalamus is small in volume but important in function in neurology practice. Talamus, hem çeşitli duyuların serebral korteksteki primer duyu merkezine iletilmesinde, hem de serebellum ve bazal gangliyonlardan gelen hareket ile ilgili bilgilerin serebral kortek-sin motor bölgelerine iletilmesinde önemli rolü olan gri cevher kitlesidir. Talamus'un fonksiyonlarının sağlanmasında görevli çekirdekleri vardır. Yine bu çekirdeklerin diğer MSS yapılarıyla bağlantıları vardır. Talamus'un demans, epilepsi, multiple skleroz, migren gibi önemli nörolojik hastalıklarda da rolü yapılan çalışmalarda ortaya konmuştur. Bu nedenle talamus boyut olarak küçük ancak fonksiyon olarak nöroloji pratiğinde önemli bir yere sahiptir.

Keywords

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References

1. * Arafl.Gör., Dr., **Yrd.Doç.Dr., Ondokuz May›s Üniversitesi T›p Fakültesi, Nöroloji Anabilim Dal›, SAMSUNKAYNAKLAR
2. Taner Do¤an, Fonksiyonel Nöroanatomi, 1. bask›, Ankara, ODTÜ Gelifltirme Vakf› Yay›nc›l›k, fiubat 1998; 179–186.
3. Ar›nc› Kaplan, Elhan Alaittin, Anatomi 2. cilt, 2. bask›, Ankara, 1997; 370–374.
4. Ö¤e A. Emre, Nöroloji, ‹stanbul, Nobel T›p Kitapevleri, ‹stanbul Üniversitesi ‹stanbul T›p Fakültesi Temel ve Klinik Bilimler Ders Kitaplar›, 2004; 216–217.
5. Lampl Y, Gilad R Bilateral ptosis and changes in state of alertness in thalamic infarction. Clin Neurol Neurosurg. 1999; 101: 49–52.
6. Kumral E, Evyapan D, Balkir K ,et al. Bilateral t h a l a m i c infarction. Clinical, etiological and MRI correlates. Acta NeurolScand.2001; 103: 35–42.
7. Mesulam M.-Marsel Çeviri Editörü: Gürvit ‹.H, Davran›flsal ve Kognitif Nörolojinin ‹lkeleri, 2. Bask›, ‹stanbul, Yelkovan Yay›nc›l›k, Ocak 2004; 186–189
8. Gonzales, Gilbert R. Central pain: Diagnosis and treatment strategies. Neurology,Volume 45(12) Supplement 9, December 1995, pp S11-S16.

9. Allen H Roper, Brown Rober H. Çeviri Editörü: Emre M, Adams and Victor’s Princeples of Neurology, 8. Bask›, ‹stanbul, Günefl Kitabevi, 2006; 424, 682, 713–4, 909.
10. Bermejo Velasco P E, Ruiz Huete C. Korsakoff’s s y n d r o m e secondary to left thalamic bleeding. Neurologia. 2006; 21: 733–736.
11. Karnath HO, Johannsen L, Broetz D, et al. Posterior thalamic hemorrhage induces “pusher syndrome”. Neurology. 2005; 22; 64: 1014–1019.
12. Sakaguchi J, Yonemura K, Hashimoto Y, et al. Herpes simplex encephalitis originating from bilateral thalamic lesions with hemorrhagic component. Rinsho Shinkeigaku. 2005; 45: 368–371.
13. Brass SD, Benedict RH, Weinstock-Guttman B, et al. Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis. Mult Scler. 2006; 12: 437–444.
14. Geurts JJ, Reuling IE, Vrenken H, et al. MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis. Magn Reson Med. 2006; 55: 478–483.
15. Linker RA, Mohr A, Cepek L, et al. Core hypothermia in multiple sclerosis: case report with magnetic r e s o n a n c e imaging localization of a thalamic lesion. Mult Scler. 2006; 12: 112–115.
16. Niepel G, Tench CR, Morgan PS, et al. Deep gray matter and fatigue in MS: A T1 relaxation time study. J Neurol. 2006; 253: 896–902.
17. Bessaih T, Bourgeais L, Badiu CI, et al. Nucleuss p e c i f i c abnormalities of GABAergic synaptic t r a n s m i s s i o n in a genetic model of absence seizures. J Neurophysiol. 2006; 96: 3074–3081.
18. Nguyen DK, Podubnaia AB, Carmant L, et al. Generalized epilepsy and classic spike-wave discharges with unilateral thalamic lesions. Arch Neurol. 2006; 63: 1321–1323.
19. Helms G, Ciumas C, Kyaga, et al. Increased thalamus levels of glutamate and glutamine (Glx) in patients with idiopathic generalised epilepsy J Neurol Neurosurg Psychiatry. 2006; 77: 489.
20. Betting LE, Mory SB, Lopes-Cendes I, et al. MRI v o l u m e t r y shows increased anterior thalamic volumes in patients with absence seizures Epilepsy Behav. 2006; 8: 575–580.
21. Liu L, Zheng T, Morris MJ, Wallengren C, et al. The mechanism of carbamazepine aggravation of absence seizures.J Pharmacol Exp Ther. 2006; 319: 790–798.
22. Shin DJ, Kim JH, Kang SS. Ophthalmoplegic migraine with reversible thalamic ischemia shown by brain SPECT. Headache. 2002; 42: 132–135
23. Shields KG, Goadsby PJ. Serotonin receptors modulate trigeminovascular responses in ventroposteromedial nucleus of thalamus: a migraine target? Neurobiol Dis. 2006; 23: 491–501.
24. Clinton SM, Haroutunian V, Meador-Woodruff JH. Up-regulation of NMDA receptor subunit and posts y n a p t i c density protein expression in the thalamus of elderly patients with schizophrenia. J Neurochem. 2006; 98: 1114–1125.
25. Lang DJ, Khorram B, Goghari VM, et al. Reduced anterior internal capsule and thalamic volumes in first-episode psychosis.Schizophr Res. 2006; 87: 89–99.
26. www.parkinsondernegi.org
27. Cavallo MA, Eleopra R, Biguzzi S, et al. Deep brain stimulation in the management of multiple sclerosis tremor. Neurol Sci. 2006 Sep; 27 Suppl 4: s3314.
28. Brodkey JA, Tasker RR, Hamani C, et al. Tremor cells in the human thalamus: differences among neurological disorders. J Neurosurg. 2004; 101: 43–47.
29. Putzer M, Barry WJ, Moringlane JR. Effect of Deep Brain Stimulation on Different Speech Subsystems in Patients with Multiple Sclerosis J Voice. 2006; 24.
30. Andrade DM, Zumsteg D, Hamani C, et al. Long-term follow-up of patients with thalamic deep brain s t i m u l a t i o n for epilepsy. Neurology. 2006; 23; 66: 1571–1573.