Tekrarlayan Düşükleri Olan Çiftlerde Kromozom Anomalileri

Abstract

Chromosomal Abnormalities in Couples with Recurrent Pregnancyloss Recurrent miscarriages affect approximately 5% of couples trying to establish a family. In this study we have investigated the chromosomal constitution of couples of with recurrent pregnancy losses in order to determine chromosomal anomaly frequencies. Samples of venous blood were obtained from 318 couples with recurrent miscarriages. Karyotyping was performed on peripheral blood lymphocytes (PBL) according to standard methods and 20 G -banded metaphases were analyzed in each case. We found abnormal chromosomes in 2.2% of patients. We conclude that patients with recurrent miscarriages should be routinely karyotyped. Tekrarlayan gebelik kayıpları, çocuk sahibi olmak isteyen çiftlerin %5'ini etkilemektedir. Çalışmamızda, tekrarlayan düşükleri olan çiftlerde kromozom anomalileri frekansını belirlemek amacıyla hastaların kromozom yapısı saptandı. Tekrarlayan düşükleri olan 318 çiftin peri-ferik kan kültürü sonuçları değerlendirildi. Tüm olgulara standart periferik kan kültürü ve Giemsa bantlama tekniği (GTG) uygulandı en az 20 metafaz sayılarak yapılan sitogenetik inceleme sonucunda olguların kromozom kuruluşu saptandı. Tekrarlayan düşükleri olan çiftlerde kromozom anomali frekansı %2.2 olarak hesaplandı. Tekrarlayan düşükleri olan çiftlere rutin karyotip analizi yapılmalıdır.

Keywords

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