Endoplazmik retikulum stresi ve katlanmamış protein cevabı

Abstract

Hücre içerisinde bir çok önemli görevi bulunan endoplazmik retikulumun (ER) bir diğer önemli görevi de protein katlanmasının sağlanmasıdır. ER’de protein katlanmasının gerçekleşmesini sağlayan glukoz düzenleyici protein 78, glukoz düzenleyici protein 94, lektin benzeri proteinler ve foldazlar bulunmaktadır. ER fonksiyon kapasitesini aşan fizyolojik veya patolojik durumlarda lümende katlanmamış ya da yanlış katlanmış protein birikimi meydana gelir ve bu durum ER stresi olarak isimlendirilmektedir. ER stresi hücre içerisinde oluştuktan sonra hücrenin hayati fonksiyonlarını devam ettirebilmek için katlanmamış protein cevabı (UPR) adı verilen sinyal yolakları devreye girmektedir. Protein kinaz RNA (PKR) benzeri ER kinaz (PERK), aktive edici transkripsiyon faktörü (ATF6), inozitol gerektiren kinaz 1 (IRE1) yolakları UPR sinyal yolaklarının başlıcalarıdır. Endoplasmic reticulum stress and unfolded protein response Another important function of the endoplasmic reticulum (ER), which has many important tasks in the cell, is to ensure the protein folding. In ER, there are glucose regulated protein 78, glucose regulated protein 94, lectin like proteins and foldases, which enable the protein folding. In case of physiological and pathological situations that exceed the function capacity of ER, unfolded or misfolded protein accumulation occurs in lumen and this case is named as ER stress. After the ER stress occurs in the cell, the signal pathways named unfolded protein response (UPR) step in for the continuance of the vital functions of the cell. Major UPR signal pathways include protein kinase RNA (PKR) like ER kinase (PERK), activating transcription factor 6 (ATF6), j requiring kinase 1 (IRE1). J. Exp. Clin. Med., 2012; 29:95-100

Keywords

• Endoplazmik retikulum; Grp78; Grp94; PERK; ATF6; IRE (Endoplasmic reticulum; Grp78; Grp94; PERK; ATF6; IRE1)

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