Lyme hastalıgı

Abstract

Kuzey yarım kürede en sık görülen zoonotik hastalıklardan biri olan Lyme hastalığı, spiroketlerin neden olduğu ve vücutta birden çok sistemi tutabilen bir hastalıktır. Kuzey Amerika’da hastalığa Borrelia burgdorferi neden olurken kuzey yarım kürenin diğer bölgelerinde farklı Borrelia türleri hastalık etkeni olabilmektedir. Tüm spiroketler gibi Lyme hastalığının da evreleri vardır ve klinik tablo her evrede farklıdır. Genellikle oral doksisiklin tedavisi ile tedaviye iyi cevap veren Lyme hastalığı’nın insidansı son yıllarda giderek artmakta ve Türkiye' de görülebilen bir hastalık haline gelmektedir. 

Keywords

• Borrelia burgdorferi
• Lyme hastalığı
• Eritema kronikum migrans
• Nöroborreliozis
• Artrit
• Kardit

References

1. Aguero-Rosenfeld, M.E., Wang, G., Schwartz, I., Wormser, G.P., 2005. Diagnosis of Lyme borreliosis. Clin. Microbiol. Rev. 18,484-509.
2. Avery, R.A., Frank, G., Eppes, S.C., 2005. Diagnostic utility of Borrelia burgdorferi cerebrospinal fluid polymerase chain reaction in children with Lyme meningitis. Pediatr. Infect. Dis. J. 24, 705-708.
3. Aydın, K., Köksal, İ., Caylan, R., 2001. Trabzon yöresinde Lyme seropozitifliği. İnfeksiyon Dergisi. 15, 141-144.
4. Bacon, R.M., Kugeler, K.J., Mead, P.S., 2008. Surveillance for Lyme disease-United States, 1992-2006. MMWR Surveill Summ. 57, 1-9.
5. Baranton, G., De Martino, S.J., 2009. Borrelia burgdorferi sensu lato diversity and its influence on pathogenicity in humans. Curr. Probl. Der- matol. 37, 1-17.
6. Barbour, A.G., 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57, 521-525.
7. Barbour, A.G., Hayes, S.F., 1986. Biology of Borrelia species. Microbiol. Rev. 50, 381.
8. Bhate, C., Schwartz, R.A., 2011. Lyme disease: Part I. Advances and perspectives. J. Am. Acad. Dermatol. 64, 619-636.

9. Bratton, R.L., Whiteside, J.W., Hovan, M.J., Engle, R.L., Edwards, F.D., 2008. Diagnosis and treatment of Lyme disease. Mayo Clin. Proc. 83, 566-571.
10. Brown, R.N., Lane, R.S., 1992. Lyme disease in California: A novel enzootic transmission cycle of Borrelia burgdorferi. Science. 256, 1439.
11. Burgdorfer, W., Barbour, A.G., Hayes, S.F., Benach, J.L., Grunwaldt, E., Davis, J.P., 1982. Lyme disease - a tick-borne spirochetosis? Science. 216, 1317-1319.
12. Connally, N.P., Durante, A.J., Yousey-Hindes, K.M., Meek, J.I., Nelson, R.S., Heimer, R., 2009. Peridomestic Lyme disease prevention: Results of a population-based case-control study. Am. J. Prev. Med. 37, 201-206.
13. CDC, 2011. Division of Vector-borne Infectious Diseases. Lyme Disease. http://www.cdc.gov/ncidod/dvbid/lyme/index.htm : Erişim tarihi:25.06.2011.
14. Çakır, N., Akandere, Y., Hekim, N., Kovancı, E., Yazıcı, H., 1990. Türkiye’de iki Lyme olgusu. Klinik Gelişim. 4, 840-842.
15. Çalışır, B., Polat, E., Yücel, A., 1997. Silivri ilçesinin bazı bölgelerindeki bir kısım evcil hayvanlardan toplanan kenelerin tür ayrımının yapılması ve Ixodes ricinus'larda Borrelia burgdorferi’nin arastırılması. Türkiye Parazitoloji Dergisi. 21, 379-382.
16. Dennis, D.T., Hayes, E.B., 2002. Epidemiology of Lyme Borreliosis. In: Kahl O, Gray JS, Lane RS, Stanek G, ed. Lyme Borreliosis: Biology, epidemiology and control. Oxford, England: CABI, 251.
17. des Vignes, F., Piesman, J., Heffernan, R., Schulze, T.L., Stafford, K.C. 3rd, Fish, D., 2001. Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs. J. Infect. Dis. 183, 773-778.
18. Dever, L.L., Jorgensen, J.H., Barbour, A.G., 1992. In vitro antimicrobial susceptibility testing of Borrelia burgdorferi: A microdilution MIC method and timekill studies. J. Clin. Microbiol. 30, 2692.
19. Doğancı, L., Baylan, O., 2002. Lyme hastalığı (Lyme Borreliyozu). Topcu AW, Söyletir G, Doğanay M. Ed. İnfeksiyon Hastalıkları ve Mikrobi- yolojisi, İstanbul, Nobel Tıp Kitabevleri. 701-712.
20. Earl, T.J., 2010. Cardiac manifestations of Lyme disease. Med. Health R I. 93, 339-341.
21. Feder, H.M. Jr., Johnson, B.J., O’Connell, S., Shapiro, E.D., , Steere, A.C., Wormser, G.P., and the Ad Hoc International Lyme Disease Group, 2007. A critical appraisal of “chronic Lyme disease”. New Engl. J. Med. 357, 1422.
22. Fikrig, E., Narasimhan, S., 2006. Borrelia burgdorferi–traveling incognito? Microbes Infect. 8, 1390.
23. Gray, J.S., 1998. The ecology of ticks transmitting Lyme borreliosis. Exp. Appl. Acarol. 22, 249-258.
24. Güner, E.S., Hashimoto, N., Takada, N., Kaneda, K., Imai, Y., Masuzawa, T., 2003. First isolation and characterization of Borrelia burgdorferi sensu lato strains from Ixodes ricinus ticks in Turkey. J. Med. Microbiol. 52, 807-813.
25. Güner, E.S., Watanabe, M., Kadosaka, T., Polat, E., Gargili, A., Gulanber, A., Ohashi, N., Kaneda, K., Imai, Y., Masuzawa, T., 2005. Seroepide- miology of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in wild mice captured in northern Turkey. Epidemiol. Infect. 133, 331-336.
26. Halperin, J.J., 2010. Nervous system Lyme disease. J.R.C.P.E. 40, 248-255.
27. Hovmark, A., Asbrink, E., Olsson, I., 1986. The spirochetal etiology of lymphadenosis benigna cutis solitaria. Acta. Derm. Venereol. 66, 479- 484.
28. Köksal, İ., Saltoğlu, N., Bingül, T., Öztürk, H., 1990. Bir Lyme hastalığı olgusu. ANKEM Derg. 4, 284.
29. Krause, P.J., Foley, D.T., Burke, G.S., Christianson, D., Closter, L., Spielman, A., 2006. Tick-Borne Disease Study Group. Reinfection and re- lapse in early Lyme disease. Am. J. Trop. Med. Hyg. 75, 1090-1094.
30. Logar, M., Ruzic-Sabljic, E., Maraspin, V., Lotric-Furlan, S., Cimperman, J., Jurca, T., Strle, F., 2004. Comparison of erythema migrans caused by Borrelia afzelii and Borrelia garinii. Infection. 32, 15-19.
31. Logigian, E.L., Kaplan, R.F., Stere, A.C., 1990. Chronic neurologic manifestations of Lyme disease. New Engl. J. Med. 323, 1438.
32. LoGiudice, K., Ostfeld, R.S., Schmidt, K.A., Keesing, F., 2003. The ecology of infectious disease: Effects of host diversity and community composition on Lyme disease risk. Proc. Natl. Acad. Sci. USA. 100, 567.
33. Lotric-Furlan, S., Petrovec, M., Avsic-Zupanc, T., Nicholson, W.L., Sumner, J.W. 2001. Prospective assessment of the etiology of acute febrile illness after a tick bite in Slovenia. Clin. Infect. Dis. 33, 503-510.
34. McAlister, H.F., Klementowicz, P.T., Andrews, C., Fisher, J.D., Feld, M., Furman, S., 1989. Lyme carditis: An important cause of reversible heart block. Ann. Intern. Med. 110, 339.
35. Montgomery, R.R., Malawista, S.E., Feen, K.J.M., Bockenstedt, L.K., 1996. Direct demonstration of antigenic substitution of Borrelia burgdor- feri ex vivo: Exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J. Exp. Med. 183, 261.
36. Mutlu, G., Gultekin, M., Ergin, C., Sayın, F., Kurşun, A.E., 1995. Antalya yöresinde Borrelia burgdorferi antikorlarının ve vektörlerinin araştırılması. Mikrobiyoloji Bülteni. 29, 1-6.
37. Müllegger, R.R., 2004. Dermatological manifestations of Lyme borreliosis. Eur. J. Dermatol. 14, 296-309.
38. Nadelman, R.B., Wormser, G.P., 2007. Reinfection in patients with Lyme disease. Clin. Infect. Dis. 45, 1032-1038.
39. Pachner, A.R., Steere, A.C., 1985. The triad of neurologic manifestations of Lyme disease: Meningitis, cranial neuritis, and radiculoneuritis. Neurology. 35, 47.
40. Peavey, C.A., Lane, R.S., 1995. Transmission of Borrelia burgdorferi by Ixodes pacificus nymphs and reservoir competence of deer mice (Pero- myscus maniculatus) infected by tick-bite. J. Parasitol. 81, 175-178.
41. Piesman, J., Gern, L., 2004. Lyme borreliosis in Europe and North America. Parasitology. 129, 191-220.
42. Schwan, T.G., Piesman, J., 2000. Temporal changes in outer surface proteins A and C of the Lyme disease- associated spirochete, Borrelia burg- dorferi, during the chain of infection in ticks and mice. J. Clin. Microbiol. 38, 382-388.
43. Schmidt, C., Plate, A., Angele, B., Pfister, H.W., Wick, M., Koedel, U., Rupprecht, T.A., 2011. A prospective study on the role of CXCL13 in Lyme neuroborreliosis. Neurology. 76, 1051-1058.
44. Shapiro, E.D., Gerber, M.A., Holabird, N.B., Berg, A.T., Feder, H.M. Jr., Bell, G.L., Rys, P.N., Persing D.H., 1992. A controlled trial of antimi- crobial prophylaxis for Lyme disease after deer-tick bites. New Engl. J. Med. 327, 1769-1773.
45. Smith, R.P., Schoen, R.T., Rahn, D.W., Sikand, V.K., Nowakowski, J., Parenti, D.L., 2002. Clinical characteristics and treatment outcomes of early Lyme disease in patients with microbiologically confirmed erythema migrans. Ann. Intern. Med. 136, 421-428.
46. Stafford, K.I., Kitron, U., 2002. Environmental management of Lyme borreliosis control. In: Gray, J.S, Kahl, O., Lane, R.S., Stanek, G., eds. Lyme borreliosis: Biology, epidemiology and control”. New York; CABI Publishing. 301-334.
47. Stanek, G., Wormser, G.P., Gray, J., Strle, F., 2011. Lyme borreliosis. Lancet. doi: 10.1016/S0140-6736(11)60103-7.
48. Steere, A.C., 1989. Lyme disease. New Engl. J. Med. 321, 586-596.
49. Steere, A.C., 2001. Lyme disease. New Engl. J. Med. 345, 115-125.
50. Steere, A.C, Grodzicki¸ R.L., Kornblatt, A.N., Craft, J.E., Barbour, A.G., Burgdorfer, W., Schmid, G.P., Johnson, E., Malawista, S.E., 1983. The spirochetal etiology of Lyme disease. New Engl. J. Med. 308, 733-740.
51. Steere, A.C., Levin, R.E., Molloy, P.J., Kalish, R.A., Abraham, J.H. 3rd, Liu NY, Schmid CH., 1994. Treatment of Lyme arthritis. Arthritis Rheum. 37, 878-888.
52. Steere, A.C., Malawista, S.E., Snydman, D.R., Shope, R.E,, Andiman, W.A., Ross, M.R., Steele, F.M., 1977. Lyme arthritis: An epidemic of oligoarticular arthritis in children and adults in three Connecticut communities. Arthritis Rheum. 20, 7-17.
53. Steere, A.C., Schoen, R.T., Taylor, E., 1987. The clinical evolution of Lyme arthritis. Ann. Intern. Med. 107, 725-731.
54. Steere, A.C., Sikand, V.K., 2003. The presenting manifestations of Lyme disease and the outcomes of treatment. New Engl. J. Med. 348, 2472- 2474.
55. Strle, F., 1999. Lyme borreliosis in Slovenia. Zentralbl Bakteriol. 289, 643-652.
56. Strle, F., Nadelman, R.B., Cimperman, J., Nowakowski, J., Picken, R.N., Schwartz, I., Maraspin, V., Aguero-Rosenfeld, M.E., Varde, S., Lotric- Furlan, S., Wormser, G.P., 1999. Comparison of culture-confirmed erythema migrans caused by Borrelia burgdorferi sensustricto in New York State and by Borrelia afzelii in Slovenia. Ann. Intern. Med. 130, 32-36.
57. Strle, K., Drouin, E.E., Shen, S., Khoury, J.E., McHugh, G., Ruzic-Sabljic, E., Strle, F., Steere, A.C., 2009. Borrelia burgdorferi stimulates mac- rophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii. J. Infect. Dis. 200, 1936-1943.
58. Swanson, J.S., Neitzel, D., Reed, K.D., Belongia, E.A., 2006. Coinfections acquired from Ixodes ticks. Clin. Microbiol. Rev. 19, 708-727.
59. Tuncer, D., Oğünç, D., Çolak, D., 1999. Yüksek riskli bölgeler ve şehirde Borrelia burgdorferi antikor prevalansı. İnfeksiyon Dergisi, 13, 325- 328.
60. Tünger, O., Buke, M., 1995. Lyme hastalığı: İzmir ve çevresindeki durum. İnfeksiyon Dergisi; 9, 345-349.
61. Xu, G., Fang, Q.Q., Keirans, J.E., Durden, L.A., 2003. Molecular phylogenetic analyses indicate that the Ixodes ricinus complex is a paraphyletic group. J. Parasitol. 89, 452-457.
62. Warshafsky, S., Lee, D.H., Francois, L.K., Nowakowski, J., Nadelman, R.B., Wormser, G.P., 2010. Efficacy of antibiotic prophylaxis for the prevention of Lyme disease: An updated systematic review and meta-analysis. J. Antimicrob. Chemother. 65, 1137-1144.
63. Weber, K., 2001. Aspects of Lyme borreliosis in Europe. Eur. J. Clin. Microbiol. Infect. Dis. 20, 6-13.
64. Wormser, G.P., Dattwyler, R.J., Shapiro, E.D., Halperin, J.J., Steere, A.C., Klempner, M.S., Krause, P.J., Bakken, J.S., Strle, F., Stanek, G., Bockenstedt, L., Fish, D., Dumler, J.S., Nadelman, R.B., 2006. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: Clinical practice guidelines by the Infectious Diseases Society of America. Clin. Infect. Dis. 43, 1089-1134.
65. Vincent, M.S., Roessner, K., Sellati, T., Huston, C.D., Sigal, L.H., Behar, S.M., Radolf, J.D., Budd, R.C., 1998. Lyme arthritis synovial gd T cells respond to Borrelia burgdorferi lipoproteins and lipidated hexapeptides. J. Immunol. 161, 5762-5771.
66. Yin, Z., Braun, J., Neure, L., Wu, P., Eggens, U., Krause, A., Kamradt, T., Sieper, J., 1997. T cell cytokine pattern in the joints of patients with Lyme arthritis and its regulation by cytokines and anticytokines. Arthritis Rheum. 40, 69-79.