The effects of albendazole-alcohol solution on the hepatobiliary system

Abstract

Most of the scolicidal agents have some toxic effects on the hepatobiliary system included albendazole. The effects of albendazole in alcohol solution on the hepatobiliary system have been investigated in a rat model. The study was performed with 40 rats divided into four groups (n=10/group), Group I: Alcohol-isotonic saline, Group II: Albendazole-isotonic saline, Group III: Albendazole-alcohol-isotonic saline, Group IV: Isotonic saline. After the application of these solutions to the hepatic duct, blood was taken from all of the rats preoperatively and on the 30th postoperative day. The liver and biliary ducts were resected for histopathological examination. No statistically significant difference was obtained for any of the biochemical parameters studied in preoperative and postoperative period among the groups. The histopathological evaluation of the liver revealed that there were no differences among the groups for portal inflammation, hydropic changes, abscess formation, hemorrhage, and fibrosis (p>0.05). According to findings of the bile duct, mild mucosal hyperplasia was observed in groups I and II, but no significant difference was found among the groups (p>0.05). Albendazole in 2% alcohol solution did not cause more hepatobiliary damage than albendazole alone in isotonic saline application on the 30th day.

Keywords

• Hydatid cyst
• Albendazole
• Sclerosing cholangitis
• Scolicidal agent

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