Comparison of effects of levonorgestrel-releasing intrauterine devices and Cu-T 380A intrauterine devices on ovarian functions

Abstract

Our aim was to compare the effects of levonorgestrel-releasing intrauterine devices (LNG-IUD) and Cu-T380 A IUDs on ovarian functions. We included 73 volunteer women aged between 20 and 35 who attended Kahramanmaras Sutcu Imam University Gynecology and Obstetrics Policlinic for contraception requests, as well as a control group of 22 vol¬unteer women aged between 20 and 35 who attended the clinic and had regular menstrual cycles and no gynecologic problems. The cases were separated into two groups: 38 pa¬tients with LNG-IUD inserted and 35 patients with Cu-T380 A IUD inserted. The patients were invited for controls on the 10th, 12th, 14th, and 21st days of their cycles in the first, second, and third months after IUD insertion. In the control visits, follicular development, follicle-stimulating hormone, luteinizing hormone, oestrogen and progesterone levels were measured. During the three monthly follow-ups of all patients, there were significant differences between ovarian function types (p=0.03). D type ovarian reaction rate was significantly lower in the LNG-IUD group (11.5% vs. 19.0%, p<0.05) and maximal size of follicles were significantly lower in the group using the LNG-IUD (p<0.05).The LNG-IUD was found to have an inhibitory effect on ovulation, which seems to increase its contraceptive effect. 

Keywords

• Contraception
• LNG-IUD (Mirena)
• Cu-T380 A IUD
• Ovulation
• FSH
• LH

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