Sistemik skleroz: Neden ve nasıl?

Abstract

Sistemik skleroz (SSk), cilt ve akciğer, kalp, böbrek ve gastrointestinal sistem gibi birçok organ ve sistemi tutabilen etiyolojisi hala bilinmeyen bir otoimmün hastalıktır. SSk’un patogenezinde; inflamasyon, mikrovasküler yapı ve immün sistemde bir dizi değişiklik, aşırı ektrasellüler matriks üretimi sorumludur. İşte bu immün sistemdeki kompleks etkileşimler sonucunda gelişen cilt ve iç organlardaki fibrozis, hastalığın klinik tablosunu oluşturur. Hastalardaki bu klinik farklılığı neyin oluşturduğu ise tam olarak bilinmemektedir. Klinik bulguların çeşitliliği SSk tedavisinin diğer romatizmal hastalıklardan daha zor ve bireysel olmasına yol açmaktadır. Fakat bu derlemede SSk tutulum özellikleri ve tedavisinden ziyade nedenleri güncel bilgiler ışığında anlatılmaya
çalışılmıştır.

Keywords

• Fibrozis
• İnflamasyon
• Lenfosit
• Otoimmünite
• Sistemik skleroz
• Vaskülopati

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31. çe artan “hedefe yönelik” tedaviler, bu “komlpkes-heterojen hastalığın” tabiatı gereği çok yüz güldürücü olmasa da çalışmalar devam etmektedir. Bugün için “neden ve nasıl”ı henüz tam olarak açıklanamayan SSk hastalarında iş gücü kaybı, yaşam kalitesi ve beden imgesinde bozulma, ileri dönemlerde eşlik edebilen depresyon gibi faktörlerden dolayı gelişen bu kısır döngü tedavi maliyetlerini de etkilemektedir.