Thyrotoxicosis

Year 2012, , 309 - 314, 07.05.2013

Engin Kut Hulusi Atmaca

https://doi.org/10.5835/jecm.omu.29.s4.018

Abstract

Thyrotoxicosis is a clinical syndrome resulting from the effect of excess circulating T3 and T4 which ultimately causes an increased metabolic rate. The source of circulating T3 and T4 is usually the thyroid gland affected from a variety of pathological processes. The most common of these are, Graves’ disease, toxic nodular goitre and functioning adenoma. Although most types of thyrotoxicosis are due to hyperthyroidism, thyrotoxicosis can also be caused by destruction of thyroid tissue, leading to release of an excess of stored thyroid hormones, and by ingestion of too much thyroid hormone.

Keywords

Hyperthyroidism, Graves, Toxic nodular goitre, Methimazole, Propylthiouracil, Radioiodine

Tirotoksikoz

Abstract

Tirotoksikoz, dolaşımda artan T3 ve T4’ün etkisiyle metabolik hız artışına neden olan klinik bir sendromdur. Artış gösteren bu T3 ve T4’ün kaynağı sıklıkla çeşitli patolojilerden etkilenen tiroid bezinin kendisidir. Hipertiroidizme yol açan bu patolojilerin çoğunu Graves hastalığı, toksik nodüler guatr ve fonksiyon gösteren adenom oluşturur. Tirotoksikozun en sık rastlanan sebepleri hipertiroidi olsa da, fazla tiroid hormonu alımı ve tiroid bezindeki destrüksiyon sonucu depolanmış hormonların kana salınması tirotoksikoz nedeni olabilir

Keywords

Hipertiroidizm, Graves hastalığı, Toksik nodüler guatr, Metimazol, Propiltiyourasil, Radyoiyot

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