Research Article

Sorafenib-induced pancreatitis

Volume: 32 Number: 3 November 17, 2015
EN

Sorafenib-induced pancreatitis

Abstract

Sorafenib is an inhibitor of multikinase proteins which is used for metastatic renal cell carcinoma and advanced stage hepatocellular carcinoma. Its side effects include serum amylase and lipase elevations anticipated to occur within first weeks of treatment but clinically and radiologically evident acute pancreatitis develops rarely. Five cases of acute pancreatitis have been reported in literature until date. The case we described here is the sixth case of clinically diagnosed acute pancreatitis. 

Keywords

References

  1. Amar et al. Li and Srinivas Saadati and Saif Kobayashi et al. Sevin et al. 69 Female Metastatic renal cell carcinoma Dose of Sorafenib 400 mg twice daily 400 mg twice daily Not reported 400 mg twice daily 400 mg twice daily 3 weeks 4 weeks Not reported 2 weeks 10 days 1014 244
  2. Fig. A cross-section from the abdominal computed tomography scan of the patient after developing pancreatitis 135 weeks and all of them resolved spontaneously. Additionally, there were no clinical or radiological findings which were suggestive of pancreatitis (Hyodo et al., 2012).
  3. Pancreatic ischemia at the earlier phase of acute pancreatitis is important for development of pancreatic necrosis. Possible mechanisms contributing to the process include chemical-induced vasoconstriction, direct damage to vessel wall, intravascular coagulation and increased endothelial permeability (Klar et al., 1990). Mitogen
  4. Activated Protein Kinase (MAPK) is a downstream effector of Ras/Raf/MEK/ERK pathway and found to be activated in acute pancreatitis (Murr et al., 2003). A marked elevation in serum VEGF level was noted in patients with acute pancreatitis but its association with the severity or prognosis of the disease could not be established (Ueda et al., 2006).
  5. Child, C.G.III., Turcotte, J.G., 1964. Surgery and portal hypertension. In: The liver and portal hypertension, Child, C.G., Eds, W.B. Saunders, Philadelphia. P.50.
  6. Hyodo, I., Adachi, M., Tsukamoto, T., Murai, M., Naito, S., Akaza, H., 2012. Serum pancreatic enzyme elevation under treatment with sorafenib.
  7. Gan. To. Kagaku. Ryoho. 39, 1651-1656.
  8. Klar, E., Messmer, K., Warshaw, A.L., Herfarth, C., 1990. Pancreatic ischaemia in experimental acute pancreatitis: Mechanism, significance and therapy. Br. J. Surg. 77, 1205-1210.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Taner Aydın This is me

Çınar Yıldırım This is me

Kader Irak This is me

Murat Kıyıcı This is me

Selim Gürel This is me

Selim Giray Nak This is me

Macit Gülten This is me

Enver Dolar This is me

Publication Date

November 17, 2015

Submission Date

September 3, 2014

Acceptance Date

-

Published in Issue

Year 2015 Volume: 32 Number: 3

APA
Ayyıldız, T., Aydın, T., Eminler, A. T., Yıldırım, Ç., Irak, K., Kıyıcı, M., Gürel, S., Nak, S. G., Gülten, M., & Dolar, E. (2015). Sorafenib-induced pancreatitis. Deneysel Ve Klinik Tıp Dergisi, 32(3), 133-135. https://izlik.org/JA97AL88ZM
AMA
1.Ayyıldız T, Aydın T, Eminler AT, et al. Sorafenib-induced pancreatitis. J. Exp. Clin. Med. 2015;32(3):133-135. https://izlik.org/JA97AL88ZM
Chicago
Ayyıldız, Talat, Taner Aydın, Ahmet Tarık Eminler, et al. 2015. “Sorafenib-Induced Pancreatitis”. Deneysel Ve Klinik Tıp Dergisi 32 (3): 133-35. https://izlik.org/JA97AL88ZM.
EndNote
Ayyıldız T, Aydın T, Eminler AT, Yıldırım Ç, Irak K, Kıyıcı M, Gürel S, Nak SG, Gülten M, Dolar E (December 1, 2015) Sorafenib-induced pancreatitis. Deneysel ve Klinik Tıp Dergisi 32 3 133–135.
IEEE
[1]T. Ayyıldız et al., “Sorafenib-induced pancreatitis”, J. Exp. Clin. Med., vol. 32, no. 3, pp. 133–135, Dec. 2015, [Online]. Available: https://izlik.org/JA97AL88ZM
ISNAD
Ayyıldız, Talat - Aydın, Taner - Eminler, Ahmet Tarık - Yıldırım, Çınar - Irak, Kader - Kıyıcı, Murat - Gürel, Selim - Nak, Selim Giray - Gülten, Macit - Dolar, Enver. “Sorafenib-Induced Pancreatitis”. Deneysel ve Klinik Tıp Dergisi 32/3 (December 1, 2015): 133-135. https://izlik.org/JA97AL88ZM.
JAMA
1.Ayyıldız T, Aydın T, Eminler AT, Yıldırım Ç, Irak K, Kıyıcı M, Gürel S, Nak SG, Gülten M, Dolar E. Sorafenib-induced pancreatitis. J. Exp. Clin. Med. 2015;32:133–135.
MLA
Ayyıldız, Talat, et al. “Sorafenib-Induced Pancreatitis”. Deneysel Ve Klinik Tıp Dergisi, vol. 32, no. 3, Dec. 2015, pp. 133-5, https://izlik.org/JA97AL88ZM.
Vancouver
1.Talat Ayyıldız, Taner Aydın, Ahmet Tarık Eminler, Çınar Yıldırım, Kader Irak, Murat Kıyıcı, Selim Gürel, Selim Giray Nak, Macit Gülten, Enver Dolar. Sorafenib-induced pancreatitis. J. Exp. Clin. Med. [Internet]. 2015 Dec. 1;32(3):133-5. Available from: https://izlik.org/JA97AL88ZM