Can we trust the positivity of semi-quantitative glucose measurement in the urine?

Abstract

Objective: As known, when the blood glucose level exceeds the renal threshold value of 180-200 mg/dL begins to be excreted with urine. Spot urine analysis is easy to perform and an important test, with false positive or negative test results incompatible with the clinic. Our aim in this study is to investigate the relationship between glucose levels in different sample types with simultaneous measurements.

Material and Method: Simultaneous fasting serum glucose, HbA1c levels and urine glucose of 2375 patients were screened retrospectively from the hospital information system between June 1, 2015 and November 30, 2015. Fasting serum glucose was measured by enzymatic hexokinase method in biochemical autoanalyzer, HbA1c was measured by chromatographic method on HPLC and urine glucose was measured semi-quantitatively by urine autoanalyzer by strip glucose oxidase method.

Results: It was found that there was a medium-strong relationship between all three results. There was significant correlation between fasting serum glucose and HbA1c (r: 0.787, p <0.001) and the correlation between urinary glucose and fasting serum glucose and HbA1c were (r: 635, p <0.001) and (r: 533, p <0.001), respectively.

Conclusion: In our study, we indicated that there is a strong correlation between the glucose results of different types of samples that we use in our laboratory. The patient's concurrently measured HbA1c and fasting serum glucose results may be helpful to the laboratory specialist to avoid both false positives and false negatives.

Keywords

• glucose,HbA1c,fasting serum glucose

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