The comparative effects of local anaesthetics on wound healing in rats: Bupivacaine vs Levobupivacaine

Abstract

 Dear editor,

I have some comments about the article that author

discussed: “relatively high vasoconstrictive activity of

levobupivacaine at the beginning of the wound-healing

process might have resulted in low tissue perfusion and

delayed epidermal and dermal regeneration”, but the

levobupivacaine has vasodilation property. (Menezes et

al., 2016) How author was concluded to such matter. The

second: in statistical analysis author wrote “statistically

significant at a p value of <0.05” but in Table 2, p<0.01

was indicated. There was no uniformity of confidence

level in statistical analysis. The third: statistical analysis

of the histopathological study was done of nine rats but

in Table 2, n=10 were written for Group B, C, and L.

There will be required to carry out further Kruskal-

Wallis test for epidermal regeneration, granulation

tissue thickness, and angiogenesis by taking n=9. This

will alter p-value too. The forth: The experimental

protocol was approved by the Institutional Animal Care

and Use Committee of Marmara University, Istanbul,

Turkey, but protocol/ reference number was missing.

This indicated that study was bogus. If author is right

the about study, then publish this letter to the editor with the certificate of animal ethics  committee approval

indicating protocol number.

Keywords

• Editor

References

1. Menezes, L.S., Souza, L.M., Santos, M.R., Mendonça, P.S., Moreira, I.J., Oliveira, A.A., 2016. Levobupivacaine induces vasodilatation, but not vasoconstriction, in rat mesenteric artery. Rev Odontol UNESP. doi: http://dx.doi.org/10.1590/1807- 2577.28415.