Does Recurrent Pregnancy Loss Have an Inflammatory Background?

Abstract

Objective: Although several pathophysiological mechanisms is defined in etiology recurrent pregnancy loss, still causes of half of the cases haven’t revealed yet. It is reported that inflammatory processes take place in the etiology of the disease. In our study, we aimed to reveal the relationship between recurrent pregnancy loss with white blood cell count (WBC), C-reactive protein (CRP) and ferritin levels. Methods: We included our study 90 pregnants having recurrent miscarriage history and 101 pregnants without this, totally 191 patients. Maternal and gestational age, height, weight, body mass index (BMI), gravidity, parity, abortion and living children count and WBC, CRP and ferritin levels of these pregnants were evaluated retrospectively. The suitability of quantitative data for normal distribution was tested by Kolmogorov-Smirnov, Shapiro-Wilk test and graphical evaluations. Student's t-test was used for comparing two groups of normally distributed quantitative data, and Mann Whitney U test was used for two-group comparisons of non-normally distributed data Result: According to outcomes, while the age (p= 0.01; p<0.05), gravidity (p= 0.00; p<0.01) and abortion counts (p= 0.004; p<0.01) of the study group were found significantly to be higher than that of the control group, weight measurement of them was significantly lower than that of the control group (p= 0.04; p<0.05). Height and BMI measurements, parity and living children counts of the groups showed no statistically significant difference (p>0.05). While WBC levels of the study group was found to be lower (p=0.045, p<0,05) than that of control group, there was no significant difference regarding ferritin and CRP levels (p> 0.05) Conclusion: In our study, WBC, CRP and ferritin parameters did not indicate the inflammatory background in recurrent pregnancy loss. We think that further prospective randomized controlled studies are required regarding these parameters.

Keywords

• Recurrent Pregnancy Loss
• White blood cell count
• C-Reactive protein
• Ferritin

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