Abstract
Comparison of Ondansetron and Lidocaine in Preventing of Rocuıonium Injection Pain
This study was conducted to compare the efficiency of ondansetron and lidocaine for arm withdrawal due to rocuronium injection pain.
The study were included 60 adult patients. Patients were divided into three groups, twenty patients in each. After cannulation with 20-gauge intravenous catheter on the dorsum of hand, saline was infused and 5-7 mg/kg thiopenthal was administered. Five seconds after thiopenthal injection, the turniquet was applied on the forearm. Group I patients received 2 cc (4 mg) ondansetron, Group II patients received 2 cc (2%) lidocaine and Group III patients received 2 cc of 0.9% saline intravenous. Fifteen seconds after study drugs administration, turniquet was released. Rocuronium 0.6 mg/kg was injected. Arm withdrawal of patients was assessed with four points scale.
Number of patients who had no pain was higher in Group II Üıan Group I and III (p<0.05), also it was higher in Group I than Group III (p<0.05).
We concluded that lidocaine was more successful than both ondansetron and placebo in relieving arm withdrawal on rocuronium injection. In addition, ondansetron was also more effective than placebo for preventing of rocuronium injection pain.
Bu çalışma, rokuronyum enjeksiyonunda görülen kol çekmenin önlenmesinde ondansetron ve lidokainin etkilerini karşılaştırmak amacıyla yapıldı.
Çalışmaya alınan 60 erişkin olgu rasgele 20'şer kişilik üç gruba ayrıldı. Hastaların el sırtından 20 G intravenöz kateter yerleştirildikten sonra şalin infüzyonuna başlandı ve 5-7 mg/kg tiyopental uygulandı. 5 saniye (sn) sonra ön kola manuel olarak turnike uygulandı. Grup I'deki olgulara 2 cc (4 mg) ondansetron, Grup H'dekilere 2 cc (40 mg) %2'lik lidokain ve Grup IU'deki olgulara ise 2 cc serum fizyolojik (SF) (%0.9) iv verildi. 15 sn sonra turnike gevşetildi. 0.6 mg/kg rokuronyum iv olarak verilip kol çekme tepkileri 4 puanlı skala ile değerlendirildi.
Rokuronyum enjeksiyonundan sonra hiç ağrısı olmayan olgu sayısı Grup H'de Grup I ve IIl'e göre daha fazla idi (p<0.05). Rokuronyum enjeksiyon ağrısının önlenmesinde, ondansetron da plaseboya göre daha etkili idi (p<0.05).
Bu çalışmanın sonucunda; rokuronyum enjeksiyonunda görülen kol çekme tepkisinin önlenmesinde lidokainin ondansetron ve plaseboya göre daha başarılı olduğu sonucuna vardık. Ayrıca, ondansetron da plaseboya göre daha etkili bulundu.
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| Primary Language | English |
|---|---|
| Journal Section | Basic Medical Sciences |
| Authors | |
| Publication Date | December 23, 2009 |
| Submission Date | November 9, 2009 |
| Published in Issue | Year 2002 Volume: 19 Issue: 3 |
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