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Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies

Year 2003, Volume: 20 Issue: 1, - , 23.12.2009

Abstract

In recent years, a relationship between the rising levels of anticardiolipin antibodies (ACA) and recurrent venous and arterial thrombotic complications has been shown. In this study, we aimed to determine whether there was a relation between central retinal venous obstruction (CRVO) and ACA.
Blood samples from 24 patients with CRVO and 29 age matched controls were studied for IgG and IgM ACA by Enzyme-Linked Immunoabsorbant assay (ELISA). Antibody levels for IgG ACA and for IgM ACA greater than 20 GPL U/ml and 10 MPL U/ml were accepted as positive. IgG ACA positivity was found in 37.5% of CRVO patients and 20.6 % in controls. On the other hand, IgM ACA positivity was detected in 29.1% and 17.2% of CRVO patients and controls groups, respectively. No statistically significant differences were found between patients and control groups for IgG ACA and IgM ACA positivity (p>0.05). Although, we found no statistically significant differences with regard to the levels of ACA in CRVO patients compared to controls, we believe that the finding of markedly higher levels of ACA in CRVO patients may help to identify the cause of CRVO in cases of unknown aetiology.



Santral Retinal Ven Tıkanıklıklarının Antikardiolipin Antikorları ile ilişkisi
Son yıllarda tekrarlayan arteriyel ve venöz trombotik komplikasyonlar ile antikardiolipin antikorları arasında bir ilişkinin varlığı saptanmıştır. Bu çalışmada santral retinal ven tıkanıklığı (SRVT) ile antikardiolipin antikorları (AKA) arasında bir bağıntının olup olmadığını ortaya koymayı amaçladık.
SRVT tespit edilen 24 hastanın ve hastalarla uygun yaş grubundan seçilen 29 kontrol'un kan örnekleri alınıp IgG ve IgM antikardiolipin antikorları ELISA yöntemi ile araştırıldı. Antikor seviyesi IgG için 20 GPL U/ml, IgM için 10 MPL U/ml'nin üstü pozitif olarak kabul edildi.
İgG AKA pozitifliği, SRVT hastalarında %37.5, kontrollerde ise %20.6 olarak tespit edildi. IgM AKA pozitifliği ise SRVT hastalarında %29.1, kontrollerde %17.2 olarak bulundu. İstatistiksel değerlendirmede hastalar ve kontrol grubu arasında anlamlı farklılık tespit edilmedi (p>0.05).
İstatiksel açıdan anlamlı farklılık bulunmasa da santral retinal ven tıkanıklığı olan hastalarda kontrol grubuna göre antikardiolipin antikor pozitifliği, özellikle de IgG AKA yüksek olarak bulundu. SRVT etiyolojisi tespit edilemeyen hastalarda antikardiolipin antikorlarının araştırılması faydalı olabilir.

Year 2003, Volume: 20 Issue: 1, - , 23.12.2009

Abstract

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Details

Primary Language English
Journal Section Basic Medical Sciences
Authors

H. Birinci This is me

A. Birinci This is me

B. Ekinci This is me

İ. Öge This is me

Publication Date December 23, 2009
Submission Date November 6, 2009
Published in Issue Year 2003 Volume: 20 Issue: 1

Cite

APA Birinci, H., Birinci, A., Ekinci, B., Öge, İ. (2009). Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies. Journal of Experimental and Clinical Medicine, 20(1). https://doi.org/10.5835/jecm.v20i1.210
AMA Birinci H, Birinci A, Ekinci B, Öge İ. Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies. J. Exp. Clin. Med. December 2009;20(1). doi:10.5835/jecm.v20i1.210
Chicago Birinci, H., A. Birinci, B. Ekinci, and İ. Öge. “Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies”. Journal of Experimental and Clinical Medicine 20, no. 1 (December 2009). https://doi.org/10.5835/jecm.v20i1.210.
EndNote Birinci H, Birinci A, Ekinci B, Öge İ (December 1, 2009) Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies. Journal of Experimental and Clinical Medicine 20 1
IEEE H. Birinci, A. Birinci, B. Ekinci, and İ. Öge, “Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies”, J. Exp. Clin. Med., vol. 20, no. 1, 2009, doi: 10.5835/jecm.v20i1.210.
ISNAD Birinci, H. et al. “Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies”. Journal of Experimental and Clinical Medicine 20/1 (December 2009). https://doi.org/10.5835/jecm.v20i1.210.
JAMA Birinci H, Birinci A, Ekinci B, Öge İ. Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies. J. Exp. Clin. Med. 2009;20. doi:10.5835/jecm.v20i1.210.
MLA Birinci, H. et al. “Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies”. Journal of Experimental and Clinical Medicine, vol. 20, no. 1, 2009, doi:10.5835/jecm.v20i1.210.
Vancouver Birinci H, Birinci A, Ekinci B, Öge İ. Association Of Central Retinal Vein Obstructions And Anticardiplipin Antibodies. J. Exp. Clin. Med. 2009;20(1).