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The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve jnjury in Rats

Year 2004, Volume: 21 Issue: 3, - , 31.12.2009

Abstract

Ratlarda Penisilin G İle Oluşturulan Travmatik Siyatik Sinir Hasarında Tenoksikamın Histopatolojik İyileşmeye Etkisi

Bu çalışmanın amacı tenoksikamın penisilin G ile oluşturulan travmatik siyatik sinir hasarında histopatolojik iyileşme üzerine olan etkisini araştırmaktır. Siyatik sinire 22 gauge keskin uçlu iğne ile girilerek 0.1 ml (25000 Ü) kristalize penisilin G enjekte edildi. Ratlar cerrahi işlem sonrası rastgele 4 gruba ayrıldılar. Grup I ve III'e intraperitoneal %0.09 NaCl'den günde 1 ml bir kez uygulandı. Grup II ve IV'e 10 mg kg-1 tenoksikam 1 ml volüm içinde günde bir kez intraperitoneal uygulandı. Grup I ve II'de birinci haftanın sonunda, Grup III ve IV ise 3. hafta sonunda, uygun koşullarda siyatik sinir eksplorasyonu yapılarak histopatolojik değerlendirme yapıldı. Bir hafta ve 3 hafta serum fizyolojik veya tenoksikam tedavisi alan gruplar arasında perinöral veya nöral iyileşme bakımından farklılık yoktu (p>0.05). Perinö-ral ve nöral enflamasyon birlikte değerlendirildiğinde gruplar arasında istatistiksel farklılık
yoktu (p>0.05).
Periferik sinirlerde, penisilin prokain enjeksiyonu sonucu ortaya çıkan sinir hasarında histo-patolojik yönden iyileşme sağlanması için sadece antienflamatuar ilaç tedavisinin yeterli derecede etkin olmadığı ve daha etkin tedavi yöntemlerinin araştırılması gerektiği kanısına varıldı.


The aim of this study was to evaluate the histopathologic healing of penicillin G induced traumatic sciatic nerve injury with tenoxicam. 22-gauge sharp edged needle was inserted into the sciatic nerve and 0.1 ml (25000 Ü) crystallized penicillin G was injected. Rats were randomly divided into four groups. 1 ml intraperitoneal 0.09% NaCl solution was administered daily for one week in group I and for three weeks in group III. Group II and IV received 10 mg kg-1 tenoxicam in 1 ml volume intraperitoneally daily, for one week in group II and for three weeks in group IV. At the end of the trial sciatic nerve was explored and evaluated histopathologically in all groups. Perineural or neural healing of groups treated with serum physiologic or tenoxicam in one or three weeks were not statistically different. There was not statistically significant difference between groups, when neural and perineural healing was evaluated together.
Anti-inflammatory drugs were not effective to obtain recovery after penicillin procaine induced injuries in the peripheral nerves, more research is needed for the effective management and treatment for sciatic nerve injury

Year 2004, Volume: 21 Issue: 3, - , 31.12.2009

Abstract

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Details

Primary Language English
Journal Section Basic Medical Sciences
Authors

F. Guldogus. This is me

E. Kelsaka This is me

Y.S. Barıs This is me

D. Karakaya. This is me

A. Senel This is me

Publication Date December 31, 2009
Submission Date October 30, 2009
Published in Issue Year 2004 Volume: 21 Issue: 3

Cite

APA Guldogus., F., Kelsaka, E., Barıs, Y., Karakaya., D., et al. (2009). The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve jnjury in Rats. Journal of Experimental and Clinical Medicine, 21(3). https://doi.org/10.5835/jecm.v21i3.101
AMA Guldogus. F, Kelsaka E, Barıs Y, Karakaya. D, Senel A. The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve jnjury in Rats. J. Exp. Clin. Med. December 2009;21(3). doi:10.5835/jecm.v21i3.101
Chicago Guldogus., F., E. Kelsaka, Y.S. Barıs, D. Karakaya., and A. Senel. “The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve Jnjury in Rats”. Journal of Experimental and Clinical Medicine 21, no. 3 (December 2009). https://doi.org/10.5835/jecm.v21i3.101.
EndNote Guldogus. F, Kelsaka E, Barıs Y, Karakaya. D, Senel A (December 1, 2009) The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve jnjury in Rats. Journal of Experimental and Clinical Medicine 21 3
IEEE F. Guldogus., E. Kelsaka, Y. Barıs, D. Karakaya., and A. Senel, “The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve jnjury in Rats”, J. Exp. Clin. Med., vol. 21, no. 3, 2009, doi: 10.5835/jecm.v21i3.101.
ISNAD Guldogus., F. et al. “The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve Jnjury in Rats”. Journal of Experimental and Clinical Medicine 21/3 (December 2009). https://doi.org/10.5835/jecm.v21i3.101.
JAMA Guldogus. F, Kelsaka E, Barıs Y, Karakaya. D, Senel A. The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve jnjury in Rats. J. Exp. Clin. Med. 2009;21. doi:10.5835/jecm.v21i3.101.
MLA Guldogus., F. et al. “The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve Jnjury in Rats”. Journal of Experimental and Clinical Medicine, vol. 21, no. 3, 2009, doi:10.5835/jecm.v21i3.101.
Vancouver Guldogus. F, Kelsaka E, Barıs Y, Karakaya. D, Senel A. The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve jnjury in Rats. J. Exp. Clin. Med. 2009;21(3).