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Gastric xanthalesmas: Report of five cases and review of the literature

Year 2015, Volume: 32 Issue: 2, 0 - , 25.06.2015

Abstract

Xanthalesmas are incidental lesions that are rarely encountered during upper gastrointestinal (GI) endoscopy. The most frequent location of xanthelasma in the upper GI tract is the stomach. The reported incidence of gastric xanthelasma is quite variable: it rangs from 0.018% to 0.8%. Upper GI xanthelasmas have a typical endoscopic appearance of yellow-white well-demarcated single or multiple nodules or plaques, with a size varying from 1 to 10 mm in diameter. Xanthelasmas are composed of large foamy cells containing lipids. In this report; five patients who attended hospital with nonspesific symptoms and xanthelasma-like lesions were incidentally found on their endoscopic examination. 

References

  • Boger, A., Hort, W., 1977. The importance of smooth muscle cells in the development of foam cells in the gastric mucosa: An electron microscopic study. Virchows. Arch. A. Pathol. Anat. Histol. 372, 287-297.
  • Chen, Y.S., Lin, J.B., Dai, K.S., Deng, B.X., Xu, L.Z., Lin, C.D., Jiang, Z.G., 1989. Gastric xanthelasma. Chin. Med. J. 102, 639-643.
  • Covotta, A., Covotta, L., D’Ambra, G., Paoletti, M., Urbano, V., Midiri, G., Bertolotti, A., 1994. Gastric xanthomatosis in a patient with severe lipid metabolic disorder (Abstract). G. Chir. 15, 29-31.
  • De Roberto, G., Ravizza, D., Fiori, G., Trovato, C., Maffini, F., Tamayo, D., Crosta, C., 2009. A massive gastric xanthomatosis. Endoscopy. 41, 54-55. doi: 10.1055/s-2008-1077442.
  • Dreude, R.B., Balart, L.A., Herrington, J.P., Beckman, E.N., Burns, T.W., 1982. Gastric xanthoma: Histologic similarity to signet ring cell carcinoma. J. Clin. Gastroenterol. 4, 217-221.
  • Gencosmanoglu, R., Sen-Oran. E., Kurtkaya-Yapicier. O., Tozun N., 2004. Xanthelasmas of the upper gastrointestinal tract. J. Gastroenterol. 39, 215-219. doi: 10.1007/s00535-003-1288-3.
  • Gravina, A.G., Lacono, A., Alagia, I., D’Armiento, F.P., Sansone, S., Romano, M., 2009. Gastric xanthomatosis associated with gastric intestinal metaplasia in a dyspeptic patient. Digest. Liver Dis. 41, 765. doi: 10.1016/j.dld.2008.08.003.
  • Gürsoy, S., Yurci, A., Torun, E., Soyuer, I., Güven, K., Ozbakir, O., Yücesoy, M., 2005. An uncommon lesion: Gastric Xanthelasma. Turk J. Gastroenterol. 16, 167-170.
  • Hori, S., Tsutsumi, Y., 1996. Helicobacter pylori infection in gastric xanthomas: Immunohistochemical analysis of 145 lesions. Pathol. Int. 46, 589-593.
  • Isomoto, H., Mizuta, Y., Inoue, K., Matsuo, T., Hayakawa, T., Miyazaki, M., Onita, K., Takeshima, F., Murase, K., Shimokawa, I., Kohno, S., 1999. A close relationship between Helicobacter pylori infection and gastric xanthoma. Scand. J. Gastroenterol. 34, 346-352.
  • Kaiserling, E., Heinle, H., Itabe, H., Takano, T., Remele, W., 1996. Lipid islands in human gastric mucosa: Morphological and immunohistochemical findings. Gastroenterology. 110, 369-374. doi: http://dx.doi.org/10.1053/gast.1996.v110.pm8566582.
  • Khachaturian, T., Dinning, J.P., Earnest, D.L., 1998. Gastric xanthelasma in a patient after partial gastrectomy. Am. J. Gastroenterol. 93, 1588- 1589.
  • Luk, I.S., Bhuta, S., Lewin, K.J., 1997. Clear cell carcinoid tumor of stomach. A variant mimicking gastric xanthelasma. Arch. Pathol. Lab. Med. 121, 1100-1103.
  • Muraoka, A., Suehiro, I., Fujii, M., Ueno, H., Hayashi, S., Shimizu, K., Kitazawa, R., Kitazawa, S., Murakami, K., 1988. Type IIa early gastric cancer with proliferation of xanthoma cells. J. Gastroenterol. 33, 326-329.
  • Naito. M., Miura. S., Funaki. C., Tateishi. T., Kuzuya. F., 1991. Gastric xanthomas in the elderly. Nippon Ronen Igakkai Zasshi. 28, 683-687.
  • Oviedo, J., Swan, N., Farraye, F.A., 2001. Gastric xanthomas. Am. J. Gastroenterol. 96, 3216-3218. doi:10.1111/j.1572-0241.2001.05293.
  • Owen, D.A., 1999. The stomach. Diagnostic surgical pathology. Sternberg, S.S., eds. Lippincott Williams and Wilkins, Philadelphia, pp. 1311- 1347.
  • Petrov, S., Churtchev, J., Mitova, R., Boyanova, L., Tarsassov, M., 1999. Xanthoma of the stomach-some morphometrical peculiarities and scanning electron microscopy. Hepato-Gastroenterol. 46, 1220-1222.
  • Scheiman, J., Elta, G., Colturi, T., Nostrant, T., 1988. Colonic xanthomatosis. Relationship to disordered motility and review of the literature. Digest. Dis. Sci. 33, 1491-1494.
  • Sekikawa, A., Fukui, H., Maruo, T., Tsumura, T., Kanesaka, T., Okabe, Y., Osaki, Y., 2013. Gastric xanthalesma may be a warning sign fort he presence of early gastric cancer. J. Gastroenterol. Hepato. 24, 951-956. doi: 10.1111/jgh.12512.
Year 2015, Volume: 32 Issue: 2, 0 - , 25.06.2015

Abstract

References

  • Boger, A., Hort, W., 1977. The importance of smooth muscle cells in the development of foam cells in the gastric mucosa: An electron microscopic study. Virchows. Arch. A. Pathol. Anat. Histol. 372, 287-297.
  • Chen, Y.S., Lin, J.B., Dai, K.S., Deng, B.X., Xu, L.Z., Lin, C.D., Jiang, Z.G., 1989. Gastric xanthelasma. Chin. Med. J. 102, 639-643.
  • Covotta, A., Covotta, L., D’Ambra, G., Paoletti, M., Urbano, V., Midiri, G., Bertolotti, A., 1994. Gastric xanthomatosis in a patient with severe lipid metabolic disorder (Abstract). G. Chir. 15, 29-31.
  • De Roberto, G., Ravizza, D., Fiori, G., Trovato, C., Maffini, F., Tamayo, D., Crosta, C., 2009. A massive gastric xanthomatosis. Endoscopy. 41, 54-55. doi: 10.1055/s-2008-1077442.
  • Dreude, R.B., Balart, L.A., Herrington, J.P., Beckman, E.N., Burns, T.W., 1982. Gastric xanthoma: Histologic similarity to signet ring cell carcinoma. J. Clin. Gastroenterol. 4, 217-221.
  • Gencosmanoglu, R., Sen-Oran. E., Kurtkaya-Yapicier. O., Tozun N., 2004. Xanthelasmas of the upper gastrointestinal tract. J. Gastroenterol. 39, 215-219. doi: 10.1007/s00535-003-1288-3.
  • Gravina, A.G., Lacono, A., Alagia, I., D’Armiento, F.P., Sansone, S., Romano, M., 2009. Gastric xanthomatosis associated with gastric intestinal metaplasia in a dyspeptic patient. Digest. Liver Dis. 41, 765. doi: 10.1016/j.dld.2008.08.003.
  • Gürsoy, S., Yurci, A., Torun, E., Soyuer, I., Güven, K., Ozbakir, O., Yücesoy, M., 2005. An uncommon lesion: Gastric Xanthelasma. Turk J. Gastroenterol. 16, 167-170.
  • Hori, S., Tsutsumi, Y., 1996. Helicobacter pylori infection in gastric xanthomas: Immunohistochemical analysis of 145 lesions. Pathol. Int. 46, 589-593.
  • Isomoto, H., Mizuta, Y., Inoue, K., Matsuo, T., Hayakawa, T., Miyazaki, M., Onita, K., Takeshima, F., Murase, K., Shimokawa, I., Kohno, S., 1999. A close relationship between Helicobacter pylori infection and gastric xanthoma. Scand. J. Gastroenterol. 34, 346-352.
  • Kaiserling, E., Heinle, H., Itabe, H., Takano, T., Remele, W., 1996. Lipid islands in human gastric mucosa: Morphological and immunohistochemical findings. Gastroenterology. 110, 369-374. doi: http://dx.doi.org/10.1053/gast.1996.v110.pm8566582.
  • Khachaturian, T., Dinning, J.P., Earnest, D.L., 1998. Gastric xanthelasma in a patient after partial gastrectomy. Am. J. Gastroenterol. 93, 1588- 1589.
  • Luk, I.S., Bhuta, S., Lewin, K.J., 1997. Clear cell carcinoid tumor of stomach. A variant mimicking gastric xanthelasma. Arch. Pathol. Lab. Med. 121, 1100-1103.
  • Muraoka, A., Suehiro, I., Fujii, M., Ueno, H., Hayashi, S., Shimizu, K., Kitazawa, R., Kitazawa, S., Murakami, K., 1988. Type IIa early gastric cancer with proliferation of xanthoma cells. J. Gastroenterol. 33, 326-329.
  • Naito. M., Miura. S., Funaki. C., Tateishi. T., Kuzuya. F., 1991. Gastric xanthomas in the elderly. Nippon Ronen Igakkai Zasshi. 28, 683-687.
  • Oviedo, J., Swan, N., Farraye, F.A., 2001. Gastric xanthomas. Am. J. Gastroenterol. 96, 3216-3218. doi:10.1111/j.1572-0241.2001.05293.
  • Owen, D.A., 1999. The stomach. Diagnostic surgical pathology. Sternberg, S.S., eds. Lippincott Williams and Wilkins, Philadelphia, pp. 1311- 1347.
  • Petrov, S., Churtchev, J., Mitova, R., Boyanova, L., Tarsassov, M., 1999. Xanthoma of the stomach-some morphometrical peculiarities and scanning electron microscopy. Hepato-Gastroenterol. 46, 1220-1222.
  • Scheiman, J., Elta, G., Colturi, T., Nostrant, T., 1988. Colonic xanthomatosis. Relationship to disordered motility and review of the literature. Digest. Dis. Sci. 33, 1491-1494.
  • Sekikawa, A., Fukui, H., Maruo, T., Tsumura, T., Kanesaka, T., Okabe, Y., Osaki, Y., 2013. Gastric xanthalesma may be a warning sign fort he presence of early gastric cancer. J. Gastroenterol. Hepato. 24, 951-956. doi: 10.1111/jgh.12512.
There are 20 citations in total.

Details

Primary Language English
Journal Section Internal Medical Sciences
Authors

Oğuzhan Dizdar

Ahmet Eminler

Talat Ayyıldız

Zeynep Kahyaoğlu This is me

Enver Dolar This is me

Publication Date June 25, 2015
Submission Date April 28, 2014
Published in Issue Year 2015 Volume: 32 Issue: 2

Cite

APA Dizdar, O., Eminler, A., Ayyıldız, T., Kahyaoğlu, Z., et al. (2015). Gastric xanthalesmas: Report of five cases and review of the literature. Journal of Experimental and Clinical Medicine, 32(2). https://doi.org/10.5835/jecm.omu.32.02.010
AMA Dizdar O, Eminler A, Ayyıldız T, Kahyaoğlu Z, Dolar E. Gastric xanthalesmas: Report of five cases and review of the literature. J. Exp. Clin. Med. July 2015;32(2). doi:10.5835/jecm.omu.32.02.010
Chicago Dizdar, Oğuzhan, Ahmet Eminler, Talat Ayyıldız, Zeynep Kahyaoğlu, and Enver Dolar. “Gastric Xanthalesmas: Report of Five Cases and Review of the Literature”. Journal of Experimental and Clinical Medicine 32, no. 2 (July 2015). https://doi.org/10.5835/jecm.omu.32.02.010.
EndNote Dizdar O, Eminler A, Ayyıldız T, Kahyaoğlu Z, Dolar E (July 1, 2015) Gastric xanthalesmas: Report of five cases and review of the literature. Journal of Experimental and Clinical Medicine 32 2
IEEE O. Dizdar, A. Eminler, T. Ayyıldız, Z. Kahyaoğlu, and E. Dolar, “Gastric xanthalesmas: Report of five cases and review of the literature”, J. Exp. Clin. Med., vol. 32, no. 2, 2015, doi: 10.5835/jecm.omu.32.02.010.
ISNAD Dizdar, Oğuzhan et al. “Gastric Xanthalesmas: Report of Five Cases and Review of the Literature”. Journal of Experimental and Clinical Medicine 32/2 (July 2015). https://doi.org/10.5835/jecm.omu.32.02.010.
JAMA Dizdar O, Eminler A, Ayyıldız T, Kahyaoğlu Z, Dolar E. Gastric xanthalesmas: Report of five cases and review of the literature. J. Exp. Clin. Med. 2015;32. doi:10.5835/jecm.omu.32.02.010.
MLA Dizdar, Oğuzhan et al. “Gastric Xanthalesmas: Report of Five Cases and Review of the Literature”. Journal of Experimental and Clinical Medicine, vol. 32, no. 2, 2015, doi:10.5835/jecm.omu.32.02.010.
Vancouver Dizdar O, Eminler A, Ayyıldız T, Kahyaoğlu Z, Dolar E. Gastric xanthalesmas: Report of five cases and review of the literature. J. Exp. Clin. Med. 2015;32(2).