Year 2016, Volume 33 , Issue 4, Pages 0 - 0 2017-07-03

Axolotl cells and tissues enhances cutaneous wound healing in mice

Turan DEMIRCAN [1] , İlknur KESKIN [2] , Yalcin GUNAL [3] , Ayse Elif ILHAN [4] , Bircan KOLBASI [5] , Gurkan OZTURK [6]


Adult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar tissue formation. However, unlike mammals, adult salamanders repair the wounds by regeneration compared to scarring. To elucidate the healing capability of a salamander, Axolotl, in a different species, here we addressed this question by treating the wounds in mice with Axolotl cells or tissues. Excisional lesions were created on each mouse, and animals in different groups treated by; a-) Axolotl blastema tissue, b-) Axolotl tail tissue, c-) Axolotl blastema cells, d-) Axolotl tail cells, e-) Serum physiologic, e-) Madecassol; respectively. 10 days after the treatments, wound healing success was compared by considering the wound closure rate, histopathological analysis, vascularization and gene expression profiling of cytokines. The results reveal that Axolotl cells or tissues delivered animals demonstrate an improved wound repair capacity. A better reepithelization, granule tissue formation, vascularization and even presence of hair follicles are observed in animals treated with Axolotl samples. Gene expression profiling data discloses the lower levels of pro-inflammatory cytokines in these animals which may indicate the immune-modulating role of Axolotl samples in wound healing. 

Axolotl, cutaneous wound healing; immune-modulation; regeneration
Journal Section Basic Medical Sciences
Authors

Author: Turan DEMIRCAN

Author: İlknur KESKIN

Author: Yalcin GUNAL

Author: Ayse Elif ILHAN

Author: Bircan KOLBASI

Author: Gurkan OZTURK

Dates

Acceptance Date : August 11, 2020
Publication Date : July 3, 2017

Bibtex @ { omujecm330339, journal = {Journal of Experimental and Clinical Medicine}, issn = {1309-4483}, eissn = {1309-5129}, address = {}, publisher = {Ondokuz Mayıs University}, year = {2017}, volume = {33}, pages = {0 - 0}, doi = {}, title = {Axolotl cells and tissues enhances cutaneous wound healing in mice}, key = {cite}, author = {Demırcan, Turan and Keskın, İlknur and Gunal, Yalcin and Ilhan, Ayse Elif and Kolbası, Bircan and Ozturk, Gurkan} }
APA Demırcan, T , Keskın, İ , Gunal, Y , Ilhan, A , Kolbası, B , Ozturk, G . (2017). Axolotl cells and tissues enhances cutaneous wound healing in mice . Journal of Experimental and Clinical Medicine , 33 (4) , 0-0 . Retrieved from https://dergipark.org.tr/en/pub/omujecm/issue/30535/330339
MLA Demırcan, T , Keskın, İ , Gunal, Y , Ilhan, A , Kolbası, B , Ozturk, G . "Axolotl cells and tissues enhances cutaneous wound healing in mice" . Journal of Experimental and Clinical Medicine 33 (2017 ): 0-0 <https://dergipark.org.tr/en/pub/omujecm/issue/30535/330339>
Chicago Demırcan, T , Keskın, İ , Gunal, Y , Ilhan, A , Kolbası, B , Ozturk, G . "Axolotl cells and tissues enhances cutaneous wound healing in mice". Journal of Experimental and Clinical Medicine 33 (2017 ): 0-0
RIS TY - JOUR T1 - Axolotl cells and tissues enhances cutaneous wound healing in mice AU - Turan Demırcan , İlknur Keskın , Yalcin Gunal , Ayse Elif Ilhan , Bircan Kolbası , Gurkan Ozturk Y1 - 2017 PY - 2017 N1 - DO - T2 - Journal of Experimental and Clinical Medicine JF - Journal JO - JOR SP - 0 EP - 0 VL - 33 IS - 4 SN - 1309-4483-1309-5129 M3 - UR - Y2 - 2020 ER -
EndNote %0 Journal of Experimental and Clinical Medicine Axolotl cells and tissues enhances cutaneous wound healing in mice %A Turan Demırcan , İlknur Keskın , Yalcin Gunal , Ayse Elif Ilhan , Bircan Kolbası , Gurkan Ozturk %T Axolotl cells and tissues enhances cutaneous wound healing in mice %D 2017 %J Journal of Experimental and Clinical Medicine %P 1309-4483-1309-5129 %V 33 %N 4 %R %U
ISNAD Demırcan, Turan , Keskın, İlknur , Gunal, Yalcin , Ilhan, Ayse Elif , Kolbası, Bircan , Ozturk, Gurkan . "Axolotl cells and tissues enhances cutaneous wound healing in mice". Journal of Experimental and Clinical Medicine 33 / 4 (July 2017): 0-0 .
AMA Demırcan T , Keskın İ , Gunal Y , Ilhan A , Kolbası B , Ozturk G . Axolotl cells and tissues enhances cutaneous wound healing in mice. J. Exp. Clin. Med.. 2017; 33(4): 0-0.
Vancouver Demırcan T , Keskın İ , Gunal Y , Ilhan A , Kolbası B , Ozturk G . Axolotl cells and tissues enhances cutaneous wound healing in mice. Journal of Experimental and Clinical Medicine. 2017; 33(4): 0-0.