Research Article
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Year 2018, Volume 35, Issue 4, 101 - 109, 18.11.2019

Abstract

References

  • Acikgoz, E. 1988. Annual forage legumes in the arid and semi-arid regions of Turkey. In Nitrogen fixation by legumes in Mediterranean agriculture. Springer. pp. 47-54.
  • Acıkgöz, E., 2001. Yem Bitkileri. Uludağ Üniv. Güçlendirme Vakfı Yayın. 182.
  • Anbalagan, V., Raju, K., Shanmugam, M., 2017. Assessment of Lipid Peroxidation and Antioxidant Status in Vanillic Acid Treated 7,12-Dimethylbenz[a]anthracene Induced Hamster Buccal Pouch Carcinogenesis. Journal of clinical and diagnostic research. 11.3.
  • Avci, S., Tekin, N., Sancak, C., Özcan, S., Maraghi, A.O., 2016. Phylogenetic relationship of some Onobrychis taxa naturally grown in Turkey based on morphology and nuclear ribosomal DNA ITS Sequences. Legume Research. 39(5), 665-673.
  • Basli, A., Belkacem, N., Amrani, I., 2017. Health benefits of phenolic compounds against cancers. Phenolic compounds-biological activity. London: InTechOpen. 193-210.
  • Bates, S.H., Jones, R.B., Bailey, C.J., 2000. Insulin‐like effect of pinitol. British journal of pharmacology. 130(8), 1944-1948.
  • Choi, E.M., Hwang, J.K., 2004. Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia. 75(6), 557-565.
  • Conforti, F., Sosa, S., Marrelli, M., Menichini, F., Statti, G A., Uzunov, D., Della Loggia, R., 2008. In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants. Journal of ethnopharmacology. 116(1), 144-151.
  • Cragg, G M., Kingston, D.G., Newman, D.J., 2005. Anticancer agents from natural products. CRC press. pp. 89-122.
  • Cragg, G M., Kingston, D.G., Newman, D.J., 2012. Anticancer agents from natural products. CRC press. pp. 123-175.
  • Desai, A.G., Qazi, G.N., Ganju, R.K., El-Tamer, M., Singh, J., Saxena, A.K., Bhat, H.K., 2008. Medicinal plants and cancer chemoprevention. Current drug metabolism. 9(7), 581-591.
  • Eitsuka, T., Tatewaki, N., Nishida, H., Nakagawa, K., Miyazawa, T., 2016. A combination of δ-tocotrienol and ferulic acid synergistically inhibits telomerase activity in DLD-1 human colorectal adenocarcinoma cells. Journal of nutritional science and vitaminology. 62(5), 281-287.
  • Gonçalves, C., Dinis, T., Batista, M.T., 2005. Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry. 66(1), 89-98.
  • Guha, G., Rajkumar, V., Mathew, L., KUMAR, R.A., 2011. The antioxidant and DNA protection potential of Indian tribal medicinal plants. Turkish Journal of Biology. 35(2), 233-242.
  • Halabalaki, M., Aligiannis, N., Papoutsi, Z., Mitakou, S., Moutsatsou, P., Sekeris, C., Skaltsounis, A.L., 2000. Three new arylobenzofurans from O n obrychis e benoides and evaluation of their binding affinity for the estrogen receptor. Journal of natural products. 63(12), 1672-1674.
  • Hashemzaei, M., Delarami Far, A., Yari, A., Heravi, R.E., Tabrizian, K., Taghdisi, S.M., Nikitovic, D., 2017. Anticancer and apoptosis inducing effects of quercetin in vitro and in vivo. Oncology reports. 38(2), 819-828.
  • Karamian, R., Asadbegy, M., 2016. Antioxidant activity, total phenolic and flavonoid contents of three Onobrychis species from Iran. Pharmaceutical sciences. 22(2), 112.
  • Katsanou, E.S., Halabalaki, M., Aligiannis, N., Mitakou, S., Skaltsounis, A.L., Alexi, X., Alexis, M.N., 2007. Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: modulation by adrenal and gonadal steroids. The Journal of steroid biochemistry and molecular biology. 104(3-5), 228-236.
  • Korkmaz, F., 2010. Isırgan Otu (Urtica dioica) Ekstresinin Kolon Kanseri Kolon Kanseri Hücre Serileri Üzerindeki Apoptotik, Antiproliferatif ve Antioksidan Etkilerinin Araştırılması. A.Ü. Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi. 45-46.
  • Lee, K.H., Xiao, Z., 2005. Podophyllotoxins and analogs. In Anticancer agents from natural products. CRC Press. 80-96.
  • Lee, K.H., Xiao, Z., 2012. Podophyllotoxins and analogs. In Anticancer agents from natural products. CRC Press. 95-122.
  • Marais, J.P., Mueller-Harvey, I., Brandt, E.V., Ferreira, D. 2000. Polyphenols, condensed tannins, and other natural products in Onobrychis viciifolia (sainfoin). Journal of Agricultural and Food Chemistry. 48(8), 3440-3447.
  • Nicodemus, K.K., Jacobs, D.R., Folsom, A.R., 2001. Whole and refined grain intake and risk of incident postmenopausal breast cancer (United States). Cancer Causes & Control. 12(10), 917-925.
  • Pang, J.H.S., Yen, J.H., Wu, H.T., Huang, S.T., 2017. Gallic acid inhibited matrix invasion and AP-1/ETS-1-mediated MMP-1 transcription in human nasopharyngeal carcinoma cells. International journal of molecular sciences. 18(7), 1354.
  • Roy, N., Narayanankutty, A., Nazeem, P.A., Valsalan, R., Babu, T. D., Mathew, D., 2016. Plant phenolics ferulic acid and p-coumaric acid inhibit colorectal cancer cell proliferation through EGFR down-regulation. Asian Pac J Cancer Prev. 17(8), 4019-4023.
  • Scarpa, E.S., Antonini, E., Palma, F., Mari, M., Ninfali, P., 2018. Antiproliferative activity of vitexin-2-O-xyloside and avenanthramides on CaCo-2 and HepG2 cancer cells occurs through apoptosis induction and reduction of pro-survival mechanisms. European journal of nutrition. 57(4), 1381-1395.
  • Tyszka-Czochara, M., Bukowska-Strakova, K., Majka, M., 2017. Metformin and caffeic acid regulate metabolic reprogramming in human cervical carcinoma SiHa/HTB-35 cells and augment anticancer activity of Cisplatin via cell cycle regulation. Food and Chemical Toxicology. 106, 260-272.
  • Veeresham, C., 2012. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res. 200-201.
  • World Health Organization, 2014. Cancer country profiles 2014. Geneva: World Health Organization.
  • Zheng, A.W., Chen, Y.Q., Zhao, L.Q., Feng, J.G., 2017. Myricetin induces apoptosis and enhances chemosensitivity in ovarian cancer cells. Oncology letters. 13(6), 4974-4978.
  • Zhu, B., Shang, B., Li, Y., Zhen, Y., 2016. Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice. Molecular medicine reports. 13(5), 4159-4166.
  • Zhu, K.C., Sun, J.M., Shen, J.G., Jin, J.Z., Liu, F., Xu, X.L., Lv, J.J., 2015. Afzelin exhibits anti-cancer activity against androgen-sensitive LNCaP and androgen-independent PC-3 prostate cancer cells through the inhibition of LIM domain kinase 1. Oncology letters. 10(4), 2359-2365.

Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells

Year 2018, Volume 35, Issue 4, 101 - 109, 18.11.2019

Abstract

In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated. With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified. In continuation of the study; the antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells were evaluated by Caspase 3, Annexin V / PI Apoptosis / Necrosis analysis, Apopxin Green and 7-AAD Apoptosis / Necrosis analysis. The antiproliferative, apop- totic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined. 

References

  • Acikgoz, E. 1988. Annual forage legumes in the arid and semi-arid regions of Turkey. In Nitrogen fixation by legumes in Mediterranean agriculture. Springer. pp. 47-54.
  • Acıkgöz, E., 2001. Yem Bitkileri. Uludağ Üniv. Güçlendirme Vakfı Yayın. 182.
  • Anbalagan, V., Raju, K., Shanmugam, M., 2017. Assessment of Lipid Peroxidation and Antioxidant Status in Vanillic Acid Treated 7,12-Dimethylbenz[a]anthracene Induced Hamster Buccal Pouch Carcinogenesis. Journal of clinical and diagnostic research. 11.3.
  • Avci, S., Tekin, N., Sancak, C., Özcan, S., Maraghi, A.O., 2016. Phylogenetic relationship of some Onobrychis taxa naturally grown in Turkey based on morphology and nuclear ribosomal DNA ITS Sequences. Legume Research. 39(5), 665-673.
  • Basli, A., Belkacem, N., Amrani, I., 2017. Health benefits of phenolic compounds against cancers. Phenolic compounds-biological activity. London: InTechOpen. 193-210.
  • Bates, S.H., Jones, R.B., Bailey, C.J., 2000. Insulin‐like effect of pinitol. British journal of pharmacology. 130(8), 1944-1948.
  • Choi, E.M., Hwang, J.K., 2004. Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia. 75(6), 557-565.
  • Conforti, F., Sosa, S., Marrelli, M., Menichini, F., Statti, G A., Uzunov, D., Della Loggia, R., 2008. In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants. Journal of ethnopharmacology. 116(1), 144-151.
  • Cragg, G M., Kingston, D.G., Newman, D.J., 2005. Anticancer agents from natural products. CRC press. pp. 89-122.
  • Cragg, G M., Kingston, D.G., Newman, D.J., 2012. Anticancer agents from natural products. CRC press. pp. 123-175.
  • Desai, A.G., Qazi, G.N., Ganju, R.K., El-Tamer, M., Singh, J., Saxena, A.K., Bhat, H.K., 2008. Medicinal plants and cancer chemoprevention. Current drug metabolism. 9(7), 581-591.
  • Eitsuka, T., Tatewaki, N., Nishida, H., Nakagawa, K., Miyazawa, T., 2016. A combination of δ-tocotrienol and ferulic acid synergistically inhibits telomerase activity in DLD-1 human colorectal adenocarcinoma cells. Journal of nutritional science and vitaminology. 62(5), 281-287.
  • Gonçalves, C., Dinis, T., Batista, M.T., 2005. Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry. 66(1), 89-98.
  • Guha, G., Rajkumar, V., Mathew, L., KUMAR, R.A., 2011. The antioxidant and DNA protection potential of Indian tribal medicinal plants. Turkish Journal of Biology. 35(2), 233-242.
  • Halabalaki, M., Aligiannis, N., Papoutsi, Z., Mitakou, S., Moutsatsou, P., Sekeris, C., Skaltsounis, A.L., 2000. Three new arylobenzofurans from O n obrychis e benoides and evaluation of their binding affinity for the estrogen receptor. Journal of natural products. 63(12), 1672-1674.
  • Hashemzaei, M., Delarami Far, A., Yari, A., Heravi, R.E., Tabrizian, K., Taghdisi, S.M., Nikitovic, D., 2017. Anticancer and apoptosis inducing effects of quercetin in vitro and in vivo. Oncology reports. 38(2), 819-828.
  • Karamian, R., Asadbegy, M., 2016. Antioxidant activity, total phenolic and flavonoid contents of three Onobrychis species from Iran. Pharmaceutical sciences. 22(2), 112.
  • Katsanou, E.S., Halabalaki, M., Aligiannis, N., Mitakou, S., Skaltsounis, A.L., Alexi, X., Alexis, M.N., 2007. Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: modulation by adrenal and gonadal steroids. The Journal of steroid biochemistry and molecular biology. 104(3-5), 228-236.
  • Korkmaz, F., 2010. Isırgan Otu (Urtica dioica) Ekstresinin Kolon Kanseri Kolon Kanseri Hücre Serileri Üzerindeki Apoptotik, Antiproliferatif ve Antioksidan Etkilerinin Araştırılması. A.Ü. Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi. 45-46.
  • Lee, K.H., Xiao, Z., 2005. Podophyllotoxins and analogs. In Anticancer agents from natural products. CRC Press. 80-96.
  • Lee, K.H., Xiao, Z., 2012. Podophyllotoxins and analogs. In Anticancer agents from natural products. CRC Press. 95-122.
  • Marais, J.P., Mueller-Harvey, I., Brandt, E.V., Ferreira, D. 2000. Polyphenols, condensed tannins, and other natural products in Onobrychis viciifolia (sainfoin). Journal of Agricultural and Food Chemistry. 48(8), 3440-3447.
  • Nicodemus, K.K., Jacobs, D.R., Folsom, A.R., 2001. Whole and refined grain intake and risk of incident postmenopausal breast cancer (United States). Cancer Causes & Control. 12(10), 917-925.
  • Pang, J.H.S., Yen, J.H., Wu, H.T., Huang, S.T., 2017. Gallic acid inhibited matrix invasion and AP-1/ETS-1-mediated MMP-1 transcription in human nasopharyngeal carcinoma cells. International journal of molecular sciences. 18(7), 1354.
  • Roy, N., Narayanankutty, A., Nazeem, P.A., Valsalan, R., Babu, T. D., Mathew, D., 2016. Plant phenolics ferulic acid and p-coumaric acid inhibit colorectal cancer cell proliferation through EGFR down-regulation. Asian Pac J Cancer Prev. 17(8), 4019-4023.
  • Scarpa, E.S., Antonini, E., Palma, F., Mari, M., Ninfali, P., 2018. Antiproliferative activity of vitexin-2-O-xyloside and avenanthramides on CaCo-2 and HepG2 cancer cells occurs through apoptosis induction and reduction of pro-survival mechanisms. European journal of nutrition. 57(4), 1381-1395.
  • Tyszka-Czochara, M., Bukowska-Strakova, K., Majka, M., 2017. Metformin and caffeic acid regulate metabolic reprogramming in human cervical carcinoma SiHa/HTB-35 cells and augment anticancer activity of Cisplatin via cell cycle regulation. Food and Chemical Toxicology. 106, 260-272.
  • Veeresham, C., 2012. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res. 200-201.
  • World Health Organization, 2014. Cancer country profiles 2014. Geneva: World Health Organization.
  • Zheng, A.W., Chen, Y.Q., Zhao, L.Q., Feng, J.G., 2017. Myricetin induces apoptosis and enhances chemosensitivity in ovarian cancer cells. Oncology letters. 13(6), 4974-4978.
  • Zhu, B., Shang, B., Li, Y., Zhen, Y., 2016. Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice. Molecular medicine reports. 13(5), 4159-4166.
  • Zhu, K.C., Sun, J.M., Shen, J.G., Jin, J.Z., Liu, F., Xu, X.L., Lv, J.J., 2015. Afzelin exhibits anti-cancer activity against androgen-sensitive LNCaP and androgen-independent PC-3 prostate cancer cells through the inhibition of LIM domain kinase 1. Oncology letters. 10(4), 2359-2365.

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Experimental Research
Authors

Muhammet Volkan BÜLBÜL>
ISTANBUL MEDIPOL UNIVERSITY, INSTITUTE OF HEALTH SCIENCES, HISTOLOGY AND EMBRYOLOGY (MEDICINE) (DR)
0000-0003-1526-2065
Türkiye


Hanefi ÖZBEK This is me
Istanbul Medipol University, Department of Medical Pharmacology,
Türkiye


Ozlem BAHADIR ACIKARA>
Ankara University, Department of Pharmacognosy
Türkiye


Serkan OZBILGIN>
Ankara University, Department of Pharmacognosy
Türkiye


Burcın ERGENE OZ This is me
Ankara University, Department of Pharmacognosy
Türkiye


Ekın KURTUL This is me
ANKARA UNIVERSITY, FACULTY OF PHARMACY
Türkiye


İlknur KESKIN> (Primary Author)
Department of Histology and Embryology, Istanbul Medipol University
Türkiye

Supporting Institution Istanbul Medipol Ünivesitesi
Project Number Bap 2016/18
Publication Date November 18, 2019
Application Date August 26, 2019
Acceptance Date September 24, 2019
Published in Issue Year 2018, Volume 35, Issue 4

Cite

Bibtex @research article { omujecm610727, journal = {Journal of Experimental and Clinical Medicine}, issn = {1309-4483}, eissn = {1309-5129}, address = {}, publisher = {Ondokuz Mayıs University}, year = {2019}, volume = {35}, number = {4}, pages = {101 - 109}, title = {Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells}, key = {cite}, author = {Bülbül, Muhammet Volkan and Özbek, Hanefi and Bahadır Acıkara, Ozlem and Ozbılgın, Serkan and Ergene Oz, Burcın and Kurtul, Ekın and Keskın, İlknur} }
APA Bülbül, M. V. , Özbek, H. , Bahadır Acıkara, O. , Ozbılgın, S. , Ergene Oz, B. , Kurtul, E. & Keskın, İ. (2019). Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells . Journal of Experimental and Clinical Medicine , 35 (4) , 101-109 . Retrieved from https://dergipark.org.tr/en/pub/omujecm/issue/50137/610727
MLA Bülbül, M. V. , Özbek, H. , Bahadır Acıkara, O. , Ozbılgın, S. , Ergene Oz, B. , Kurtul, E. , Keskın, İ. "Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells" . Journal of Experimental and Clinical Medicine 35 (2019 ): 101-109 <https://dergipark.org.tr/en/pub/omujecm/issue/50137/610727>
Chicago Bülbül, M. V. , Özbek, H. , Bahadır Acıkara, O. , Ozbılgın, S. , Ergene Oz, B. , Kurtul, E. , Keskın, İ. "Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells". Journal of Experimental and Clinical Medicine 35 (2019 ): 101-109
RIS TY - JOUR T1 - Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells AU - Muhammet Volkan Bülbül , Hanefi Özbek , Ozlem Bahadır Acıkara , Serkan Ozbılgın , Burcın Ergene Oz , Ekın Kurtul , İlknur Keskın Y1 - 2019 PY - 2019 N1 - DO - T2 - Journal of Experimental and Clinical Medicine JF - Journal JO - JOR SP - 101 EP - 109 VL - 35 IS - 4 SN - 1309-4483-1309-5129 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Experimental and Clinical Medicine Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells %A Muhammet Volkan Bülbül , Hanefi Özbek , Ozlem Bahadır Acıkara , Serkan Ozbılgın , Burcın Ergene Oz , Ekın Kurtul , İlknur Keskın %T Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells %D 2019 %J Journal of Experimental and Clinical Medicine %P 1309-4483-1309-5129 %V 35 %N 4 %R %U
ISNAD Bülbül, Muhammet Volkan , Özbek, Hanefi , Bahadır Acıkara, Ozlem , Ozbılgın, Serkan , Ergene Oz, Burcın , Kurtul, Ekın , Keskın, İlknur . "Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells". Journal of Experimental and Clinical Medicine 35 / 4 (November 2019): 101-109 .
AMA Bülbül M. V. , Özbek H. , Bahadır Acıkara O. , Ozbılgın S. , Ergene Oz B. , Kurtul E. , Keskın İ. Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells. J. Exp. Clin. Med.. 2019; 35(4): 101-109.
Vancouver Bülbül M. V. , Özbek H. , Bahadır Acıkara O. , Ozbılgın S. , Ergene Oz B. , Kurtul E. , Keskın İ. Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells. Journal of Experimental and Clinical Medicine. 2019; 35(4): 101-109.
IEEE M. V. Bülbül , H. Özbek , O. Bahadır Acıkara , S. Ozbılgın , B. Ergene Oz , E. Kurtul and İ. Keskın , "Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells", Journal of Experimental and Clinical Medicine, vol. 35, no. 4, pp. 101-109, Nov. 2019