In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated. With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified. In continuation of the study; the antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells were evaluated by Caspase 3, Annexin V / PI Apoptosis / Necrosis analysis, Apopxin Green and 7-AAD Apoptosis / Necrosis analysis. The antiproliferative, apop- totic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined.
Primary Language | English |
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Subjects | Health Care Sciences and Services |
Journal Section | Experimental Research |
Authors |
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Supporting Institution | Istanbul Medipol Ünivesitesi |
Project Number | Bap 2016/18 |
Publication Date | November 18, 2019 |
Application Date | August 26, 2019 |
Acceptance Date | September 24, 2019 |
Published in Issue | Year 2018, Volume 35, Issue 4 |
Bibtex | @research article { omujecm610727, journal = {Journal of Experimental and Clinical Medicine}, issn = {1309-4483}, eissn = {1309-5129}, address = {}, publisher = {Ondokuz Mayıs University}, year = {2019}, volume = {35}, number = {4}, pages = {101 - 109}, title = {Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells}, key = {cite}, author = {Bülbül, Muhammet Volkan and Özbek, Hanefi and Bahadır Acıkara, Ozlem and Ozbılgın, Serkan and Ergene Oz, Burcın and Kurtul, Ekın and Keskın, İlknur} } |
APA | Bülbül, M. V. , Özbek, H. , Bahadır Acıkara, O. , Ozbılgın, S. , Ergene Oz, B. , Kurtul, E. & Keskın, İ. (2019). Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells . Journal of Experimental and Clinical Medicine , 35 (4) , 101-109 . Retrieved from https://dergipark.org.tr/en/pub/omujecm/issue/50137/610727 |
MLA | Bülbül, M. V. , Özbek, H. , Bahadır Acıkara, O. , Ozbılgın, S. , Ergene Oz, B. , Kurtul, E. , Keskın, İ. "Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells" . Journal of Experimental and Clinical Medicine 35 (2019 ): 101-109 <https://dergipark.org.tr/en/pub/omujecm/issue/50137/610727> |
Chicago | Bülbül, M. V. , Özbek, H. , Bahadır Acıkara, O. , Ozbılgın, S. , Ergene Oz, B. , Kurtul, E. , Keskın, İ. "Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells". Journal of Experimental and Clinical Medicine 35 (2019 ): 101-109 |
RIS | TY - JOUR T1 - Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells AU - Muhammet Volkan Bülbül , Hanefi Özbek , Ozlem Bahadır Acıkara , Serkan Ozbılgın , Burcın Ergene Oz , Ekın Kurtul , İlknur Keskın Y1 - 2019 PY - 2019 N1 - DO - T2 - Journal of Experimental and Clinical Medicine JF - Journal JO - JOR SP - 101 EP - 109 VL - 35 IS - 4 SN - 1309-4483-1309-5129 M3 - UR - Y2 - 2019 ER - |
EndNote | %0 Journal of Experimental and Clinical Medicine Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells %A Muhammet Volkan Bülbül , Hanefi Özbek , Ozlem Bahadır Acıkara , Serkan Ozbılgın , Burcın Ergene Oz , Ekın Kurtul , İlknur Keskın %T Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells %D 2019 %J Journal of Experimental and Clinical Medicine %P 1309-4483-1309-5129 %V 35 %N 4 %R %U |
ISNAD | Bülbül, Muhammet Volkan , Özbek, Hanefi , Bahadır Acıkara, Ozlem , Ozbılgın, Serkan , Ergene Oz, Burcın , Kurtul, Ekın , Keskın, İlknur . "Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells". Journal of Experimental and Clinical Medicine 35 / 4 (November 2019): 101-109 . |
AMA | Bülbül M. V. , Özbek H. , Bahadır Acıkara O. , Ozbılgın S. , Ergene Oz B. , Kurtul E. , Keskın İ. Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells. J. Exp. Clin. Med.. 2019; 35(4): 101-109. |
Vancouver | Bülbül M. V. , Özbek H. , Bahadır Acıkara O. , Ozbılgın S. , Ergene Oz B. , Kurtul E. , Keskın İ. Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells. Journal of Experimental and Clinical Medicine. 2019; 35(4): 101-109. |
IEEE | M. V. Bülbül , H. Özbek , O. Bahadır Acıkara , S. Ozbılgın , B. Ergene Oz , E. Kurtul and İ. Keskın , "Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells", Journal of Experimental and Clinical Medicine, vol. 35, no. 4, pp. 101-109, Nov. 2019 |