Case Report
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Two Different Regenerative Injections in Patients Diagnosed with Secondary Hip Osteoarthritis: A Report of Two Cases

Year 2021, Volume: 38 Issue: 2, 204 - 207, 03.04.2021

Abstract

Non-surgical treatment options are limited in hip osteoarthritis secondary to developmental dysplasia of the hip (DDH). Treatment of Autologous Conditioned Serum (ACS) is based on the high level of anti-inflammatory cytokine production of leukocytes in peripheral blood. It is an effective treatment option which contains the cytokines and the growth factors. Platelet Rich Plasma (PRP) is a form of treatment that stimulates natural healing steps through growth factors in platelets. In this case report we aimed to present the results of ACS and PRP injection in two patients who developed secondary coxarthrosis after DDH surgery. At the 1-year follow-up examination, patient’s functional scores improved and requirement for non-steroid anti- inflammatory drugs had significantly reduced. Regenerative injections either autologous conditioned serum or platelet rich plasma treatments are safe and effective treatments and can be recommended particularly for cases of secondary hip osteoarthritis associated with DDH.

References

  • Referans1: Abate, M., et al., 2008. Viscosupplementation with hyaluronic acid in hip osteoarthritis (a review). Ups J Med Sci. 113, 261-77.
  • Referans2: Alsousou, J., et al., 2009. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br. 91, 987-96.
  • Referans3: Andia, I., Sanchez, M., Maffulli, N., 2012. Joint pathology and platelet-rich plasma therapies. Expert Opin Biol Ther. 12, 7-22.
  • Referans4: Arend, W.P., et al., 1998. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 16, 27-55.
  • Referans5: Auw Yang, K.G., et al., 2008. Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthritis Cartilage. 16, 498-505.
  • Referans6: Baltzer, A.W., et al., 2009. Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthritis Cartilage. 17, 152-60.
  • Referans7: Baltzer, A.W., et al., 2013. A new treatment for hip osteoarthritis: clinical evidence for the efficacy of autologous conditioned serum. Orthop Rev (Pavia). 5, 59-64.
  • Referans8: Dallari, D., et al., 2016. Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study. Am J Sports Med. 44, 664-71.
  • Referans9: Evans, C.H., 2005. Novel biological approaches to the intra-articular treatment of osteoarthritis. BioDrugs. 19, 355-62.
  • Referans10: Fajardo, M., Di Cesare, P.E., 2005. Disease-modifying therapies for osteoarthritis : current status. Drugs Aging. 22, 141-61.
  • Referans11: Frizziero, A., et al., 2013. Autologous conditioned serum for the treatment of osteoarthritis and other possible applications in musculoskeletal disorders. Br Med Bull. 105, 169-84.
  • Referans12: Goldring, M.B., 2001. Anticytokine therapy for osteoarthritis. Expert Opin Biol Ther. 1, 817- 29.
  • Referans13: Harirforoosh, S., Asghar, W., Jamali, F., 2013. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 16, 821-47.
  • Referans14: Kosuge, D., et al., 2013. Management of developmental dysplasia of the hip in young adults: current concepts. Bone Joint J. 95-B, 732-7.
  • Referans15: Kruse, D.W., 2008. Intraarticular cortisone injection for osteoarthritis of the hip. Is it effective? Is it safe? Curr Rev Musculoskelet Med. 1, 227-33.
  • Referans16: Lopez-Vidriero, E., et al., 2010. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy. 26, 269-78.
  • Referans17: Sanchez, M., et al., 2009. Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med. 39, 345-54.
  • Referans18: Sanchez, M., et al., 2012. Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. Rheumatology (Oxford). 51, 144-50.
  • Referans19: Say, F., et al., 2013. Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis. Acta Chir Orthop Traumatol Cech. 80, 278-83.
  • Referans20: Tassara, M., et al., 2018. Autologous conditioned serum (ACS) for intra-articular treatment inOsteoarthritis: Retrospective report of 28 cases. Transfus Apher Sci. 57, 573-577.
  • Referans21: Tetlow, L.C., Adlam, D.J., Woolley, D.E., 2001. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum. 44, 585-94.
  • Referans22: Wehling, P., et al., 2007. Autologous conditioned serum in the treatment of orthopedic diseases:the orthokine therapy. BioDrugs. 21, 323-32.
Year 2021, Volume: 38 Issue: 2, 204 - 207, 03.04.2021

Abstract

References

  • Referans1: Abate, M., et al., 2008. Viscosupplementation with hyaluronic acid in hip osteoarthritis (a review). Ups J Med Sci. 113, 261-77.
  • Referans2: Alsousou, J., et al., 2009. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br. 91, 987-96.
  • Referans3: Andia, I., Sanchez, M., Maffulli, N., 2012. Joint pathology and platelet-rich plasma therapies. Expert Opin Biol Ther. 12, 7-22.
  • Referans4: Arend, W.P., et al., 1998. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 16, 27-55.
  • Referans5: Auw Yang, K.G., et al., 2008. Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthritis Cartilage. 16, 498-505.
  • Referans6: Baltzer, A.W., et al., 2009. Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthritis Cartilage. 17, 152-60.
  • Referans7: Baltzer, A.W., et al., 2013. A new treatment for hip osteoarthritis: clinical evidence for the efficacy of autologous conditioned serum. Orthop Rev (Pavia). 5, 59-64.
  • Referans8: Dallari, D., et al., 2016. Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study. Am J Sports Med. 44, 664-71.
  • Referans9: Evans, C.H., 2005. Novel biological approaches to the intra-articular treatment of osteoarthritis. BioDrugs. 19, 355-62.
  • Referans10: Fajardo, M., Di Cesare, P.E., 2005. Disease-modifying therapies for osteoarthritis : current status. Drugs Aging. 22, 141-61.
  • Referans11: Frizziero, A., et al., 2013. Autologous conditioned serum for the treatment of osteoarthritis and other possible applications in musculoskeletal disorders. Br Med Bull. 105, 169-84.
  • Referans12: Goldring, M.B., 2001. Anticytokine therapy for osteoarthritis. Expert Opin Biol Ther. 1, 817- 29.
  • Referans13: Harirforoosh, S., Asghar, W., Jamali, F., 2013. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 16, 821-47.
  • Referans14: Kosuge, D., et al., 2013. Management of developmental dysplasia of the hip in young adults: current concepts. Bone Joint J. 95-B, 732-7.
  • Referans15: Kruse, D.W., 2008. Intraarticular cortisone injection for osteoarthritis of the hip. Is it effective? Is it safe? Curr Rev Musculoskelet Med. 1, 227-33.
  • Referans16: Lopez-Vidriero, E., et al., 2010. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy. 26, 269-78.
  • Referans17: Sanchez, M., et al., 2009. Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med. 39, 345-54.
  • Referans18: Sanchez, M., et al., 2012. Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. Rheumatology (Oxford). 51, 144-50.
  • Referans19: Say, F., et al., 2013. Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis. Acta Chir Orthop Traumatol Cech. 80, 278-83.
  • Referans20: Tassara, M., et al., 2018. Autologous conditioned serum (ACS) for intra-articular treatment inOsteoarthritis: Retrospective report of 28 cases. Transfus Apher Sci. 57, 573-577.
  • Referans21: Tetlow, L.C., Adlam, D.J., Woolley, D.E., 2001. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum. 44, 585-94.
  • Referans22: Wehling, P., et al., 2007. Autologous conditioned serum in the treatment of orthopedic diseases:the orthokine therapy. BioDrugs. 21, 323-32.
There are 22 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Report
Authors

Ferhat Say

İsmail Büyükceran This is me

Sina Coşkun 0000-0003-2965-3112

Publication Date April 3, 2021
Submission Date April 14, 2020
Acceptance Date December 16, 2020
Published in Issue Year 2021 Volume: 38 Issue: 2

Cite

APA Say, F., Büyükceran, İ., & Coşkun, S. (2021). Two Different Regenerative Injections in Patients Diagnosed with Secondary Hip Osteoarthritis: A Report of Two Cases. Journal of Experimental and Clinical Medicine, 38(2), 204-207.
AMA Say F, Büyükceran İ, Coşkun S. Two Different Regenerative Injections in Patients Diagnosed with Secondary Hip Osteoarthritis: A Report of Two Cases. J. Exp. Clin. Med. April 2021;38(2):204-207.
Chicago Say, Ferhat, İsmail Büyükceran, and Sina Coşkun. “Two Different Regenerative Injections in Patients Diagnosed With Secondary Hip Osteoarthritis: A Report of Two Cases”. Journal of Experimental and Clinical Medicine 38, no. 2 (April 2021): 204-7.
EndNote Say F, Büyükceran İ, Coşkun S (April 1, 2021) Two Different Regenerative Injections in Patients Diagnosed with Secondary Hip Osteoarthritis: A Report of Two Cases. Journal of Experimental and Clinical Medicine 38 2 204–207.
IEEE F. Say, İ. Büyükceran, and S. Coşkun, “Two Different Regenerative Injections in Patients Diagnosed with Secondary Hip Osteoarthritis: A Report of Two Cases”, J. Exp. Clin. Med., vol. 38, no. 2, pp. 204–207, 2021.
ISNAD Say, Ferhat et al. “Two Different Regenerative Injections in Patients Diagnosed With Secondary Hip Osteoarthritis: A Report of Two Cases”. Journal of Experimental and Clinical Medicine 38/2 (April 2021), 204-207.
JAMA Say F, Büyükceran İ, Coşkun S. Two Different Regenerative Injections in Patients Diagnosed with Secondary Hip Osteoarthritis: A Report of Two Cases. J. Exp. Clin. Med. 2021;38:204–207.
MLA Say, Ferhat et al. “Two Different Regenerative Injections in Patients Diagnosed With Secondary Hip Osteoarthritis: A Report of Two Cases”. Journal of Experimental and Clinical Medicine, vol. 38, no. 2, 2021, pp. 204-7.
Vancouver Say F, Büyükceran İ, Coşkun S. Two Different Regenerative Injections in Patients Diagnosed with Secondary Hip Osteoarthritis: A Report of Two Cases. J. Exp. Clin. Med. 2021;38(2):204-7.