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Year 2021, Volume: 38 Issue: 2, 125 - 131, 03.04.2021

Abstract

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References

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Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital

Year 2021, Volume: 38 Issue: 2, 125 - 131, 03.04.2021

Abstract

Since December 2019, 2019 outbreak of coronavirus (Covid-19) spread all over the world as well as in Turkey.In this study, we aimed to investigate the clinical and laboratory effects of covid 19 disease on children. The epidemiological, laboratory, radiological, and treatment features of the 30 pediatric patients with covid-19 evaluated retrospectively. The median age of the patients was 10 years, boys and girls ratio was 1.5 (18/12). Of the patients, 80.7% had family contact and 11.5% had comorbidity. The most common symptom was fever (84.6%), and cough was the second frequency (57.7%). All patients except 1 patient had a mild course, 5 were asymptomatic. One patient needed intensive care who had underlying chronic disease. Neutropenia was the most common laboratory anomaly (36.6%). Increased D-dimer levels were observed in 9 patients (30%), decreased leukocyte was in 7 patients (23.3%) and increased lactate dehydrogenaz level was in 8 patients (26.6%). Chest computed tomography was taken 14 patients who had an abnormal X-rays, and ground-glass opacities were seen in 6 patients (20%). Hydroxychlorachine and azithromycin treatment was given to the necessary patients. In conclusion, pediatric covid 19 is mostly transmitted by family contact and has a mild course if there is no underlying disease. The most common symptoms are fever and cough. Ground glass densities on lung tomography are similar to adult. The mean PCR negative time in the treated symptomatic group was 8.8 +5.34 day, while in the untreated asymptomatic group it was 12 + 5.19 day and there was no statistically significant difference (p=0.154). The correlation between PCR negative time and clinical, laboratory, and radiological findings was examined and no correlation was found.

References

  • 1- Jiatong, S., Wenjun, L., 2020. Epidemiological characteristics and prevention and control measures of Corona Virus Disease 2019 in children. J. Trop. Med. 20,153-156.
  • 2- She, J., Liu, L., Liu, W., 2020. COVID-19 epidemic: Disease characteristics in children. J. Med. Virol.92,747-754.
  • 3- World Health Organization (WHO). WHO characterizes COVID‐19 as a pandemic [EB/OL]. Geneva, Switzerland: World Health Organization; 2020. https://www.who.int/emergencies/diseases/novel‐coronavirus‐2019/events‐as‐they‐happen
  • 4- World Health Organization. Novel coronavirus (COVID-19) situation. https://covid19.who.int/. Updated 2020. Accessed May 18, 2020.
  • 5- Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., et al., 2020. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 395:507-513.
  • 6- Lu, X., Zhang, L., Du, H., Zhang, J., Li, YY., Qu, J., et al., 2020. SARS-CoV-2 Infection in Children. N. Engl. J. Med.38,1663-1665.
  • 7- Qiu, H., Wu, J., Hong, L., Luo, Y., Song, Q., Chenet, D., 2020. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet. Infect. Dis.20,689-696.
  • 8- Parry, J., 2020. Wuhan: Britons to be evacuated as scientists estimate 44 000 cases of 2019nCOV in the city. Brit. Med. J.368,351.
  • 9- Riou, J., Althaus, CL., 2020. Pattern of early humantohuman transmission of Wuhan 2019 novel coronavirus (2019nCoV), December 2019 to January 2020. Euro. Surveill. 25,7-11.
  • 10- Hui, DS., Azhar, EI., Madani, TA., Ntoumi, F., Kock, R., Dar, O., et al., 2020. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-the latest 2019 novel coronavirus outbreak inWuhan, China. Int. J. Infect. Dis. 91,264-266
  • 11- Garazzino, S., Montagnani, C., Donà, D., Meini, A., Felici, E., Vergine, G., et al.,2020. Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020. Euro. Surveill.25,2000600.
  • 12- Zhou, P., Yang, XL., Wang, XG., Hu, B., Zhang, L., Zhang, W., et al., 2020. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature.579,270-273.
  • 13- Zhang, H., Kang, Z., Gong, H., Xu, D., Wang, J., Li, Z., et al., 2020. The digestive system is a potential route of 2019‐nCov infection: a bioinformatics analysis based on single‐cell transcriptomes. Gut.0,1-9.
  • 14- Guo, L., Ren, L., Yang, S., Xiao, M., Chang, D., Yang, F., et al.,2020 Profiling early humoral response to diagnose novel coronavirus disease (COVID-19). Clin. Infect. Dis. 71, 778-785.
  • 15- Yang, PU., Liu, P., Li, D.,Zhao D., 2020. Corona Virus Disease 2019, a growing threat to children? J. Infect. 80,671-693.
  • 16- Dong, Y., Mo, X., Hu, Y., Qi, X., Jiang, F., Jiang, Z., et al.,2020. Epidemiology of COVID-19 among children in China. Pediatrics.14,20200702.
  • 17- Wei, M., Yuan, J., Liu, YU., Fu, T., Yu, X., Zhang, ZJ., 2020. Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 14, 14.
  • 18- Lu, X., Xing, Y., Wong, GW., 2020. COVID-19: lessons to date from China. Arch Dis Child. Arch. Dis. Child.0,1–5.
  • 19- Jiehao, C., Jin, X., Daojiong, L., Zhi, Y., Lei, X., Zhenghai, Q., et al., 2020. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin. Infect. Dis. 28,28.
  • 20- WHO. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19. (https://www.who.int/docs/defaultsource/coronaviruse/who-china-joint-mission-on-covid-19-finalreport.pdf; accessed: March 19, 2020), 2020
  • 21- Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Chang, G., et al., 2020. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl. Pediatr. 9,51-60.
  • 22- Qiu, H., Wu, J., Hong, L., Luo, Y., Song, Q., Chen, D.,2020.Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China:an observational cohort study. Lancet. Infect. Dis. 20, 689-696.
  • 23- Korkmaz, MF., Türe, E., Dorum, BA., Kılıç, ZB., 2020. The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study. J. Korean. Med. Sci. 35, e236.
  • 24- Babyn, PS., Chu, WC., Tsou, IY., Wansaicheong, GK., Allen, U., Bitnun, A., et al., 2004. Severe acute respiratory syndrome (SARS): chest radiographic features in children.Pediatr. Radiol.34,47–58.
  • 25- Xia, W., Shao, J., Guo, YU., Peng, X., Li, Z., Hu, D., 2020. Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. Pediatr. Pulmonol. 05, 05.
  • 26- Yeo, C., Kaushal, S., Yeo, D., 2020. Enteric involvement of coronaviruses: is fecal‐oral transmission of SARS‐CoV‐2 possible. Lancet Gastroenterology& Hepatology. 5,335‐337.
  • 27- Henry, BM., Lippi, G., Plebani, M., 2020. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin. Chem. Lab. Med. 16,16.
  • 28- Li, W., Cui, H., Li, K., Fang, Y., L,i S., 2020. Chest computed tomography in children with COVID-19 respiratory infection. Pediatr. Radiol.50,796-799.
  • 29- Zhang, C., Gu, J., Chen, Q., Deng, N., Li, J., Huang, L., Zhou, X., 2020. Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series. PLoS. Med.17, e1003130. 10
  • 30- Gautret, P., Lagier, JC., Parola, P., Hoang, VT., Meddeb, L., Mailhe, M., et al. 2020. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int. J. Antimicrob. Agents. 56, 105949.
  • 31- Jin, YH., Cai, L., Cheng, ZS., Cheng, H., Deng, T., Fan, YP., et al., 2020. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil. Med. Res.7, 4.
There are 31 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Esra Akyüz Özkan 0000-0001-9412-8010

Emine Hafize Erdeniz This is me 0000-0003-2669-0890

Publication Date April 3, 2021
Submission Date September 26, 2020
Acceptance Date December 9, 2020
Published in Issue Year 2021 Volume: 38 Issue: 2

Cite

APA Akyüz Özkan, E., & Erdeniz, E. H. (2021). Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital. Journal of Experimental and Clinical Medicine, 38(2), 125-131.
AMA Akyüz Özkan E, Erdeniz EH. Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital. J. Exp. Clin. Med. April 2021;38(2):125-131.
Chicago Akyüz Özkan, Esra, and Emine Hafize Erdeniz. “Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital”. Journal of Experimental and Clinical Medicine 38, no. 2 (April 2021): 125-31.
EndNote Akyüz Özkan E, Erdeniz EH (April 1, 2021) Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital. Journal of Experimental and Clinical Medicine 38 2 125–131.
IEEE E. Akyüz Özkan and E. H. Erdeniz, “Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital”, J. Exp. Clin. Med., vol. 38, no. 2, pp. 125–131, 2021.
ISNAD Akyüz Özkan, Esra - Erdeniz, Emine Hafize. “Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital”. Journal of Experimental and Clinical Medicine 38/2 (April 2021), 125-131.
JAMA Akyüz Özkan E, Erdeniz EH. Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital. J. Exp. Clin. Med. 2021;38:125–131.
MLA Akyüz Özkan, Esra and Emine Hafize Erdeniz. “Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital”. Journal of Experimental and Clinical Medicine, vol. 38, no. 2, 2021, pp. 125-31.
Vancouver Akyüz Özkan E, Erdeniz EH. Evaluation of Children Followed up for Covid 19 in a Tertiary Hospital. J. Exp. Clin. Med. 2021;38(2):125-31.