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Year 2021, Volume: 38 Issue: 2s, 65 - 70, 18.03.2021

Abstract

Project Number

OMU KAEK 2013/301 ETİK KURUL İZİNİ İLE ÇALIŞMA YAPILMIŞTIR.

References

  • References 1. Seip B.,Bretthauer M., Dahler S.Patient satisfaction with on-demand sedation for out patient colonoscopy. Endoscopy, 2010. 42(8): p. 639-46.
  • 2. Akcaboy, Z.N.,Akcaboy, E. Y.Albayrak, D.Altinoren, B.Dikmen, B.Gogus, N.Can remifentanil be a better choice than propofol for colonoscopy during monitored anesthesia care?Acta Anaesthesiol Scand, 2006. 50(6): p. 736-41.
  • 3. Mourad M, El-Hamamsy M, and Anwar M, Low dose ketamine reduces sedative doses of propofol during ambulatory transoesophageal echocardiography. Egypt J Anaesth 2004. 20: p. 41–46.
  • 4. Willman, E.V. and G. Andolfatto, A prospective evaluation of "ketofol" (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department. Ann Emerg Med, 2007. 49(1): p. 23-30.
  • 5. Andolfatto, G. and E. Willman, A prospective case series of single-syringe ketamine-propofol (Ketofol) for emergency department procedural sedation and analgesia in adults. Acad Emerg Med, 2011. 18(3): p. 237-45.
  • 6. Shah A.,Mosdossy G., McLeod S., Lehnhardt K., Peddle M., Rieder M.A blinded, randomized controlled trial to evaluate ketamine/propofol versus ketamine alone for procedural sedation in children.AnnEmergMed, 2011. 57(5): p. 425-33 e2.
  • 7. Andolfatto, G. and E. Willman, A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol). Acad Emerg Med, 2010. 17(2): p. 194-201.
  • 8. Smischney, N.J.,Beach, M. L.Loftus, R. W.Dodds, T. M.Koff, M. Ketamine /propofoladmixture (ketofol) is associated with improved hemodynamics as an inductionagent: a randomized, controlledtrial. J TraumaAcuteCareSurg, 2012. 73(1): p. 94-101.
  • 9. Akin, A.,Esmaoglu A., Tosun Z., Gulcu N., Aydogan H., Boyaci A.Comparison of propofol with propofol-ketamine combination in pediatric patients undergoing auditory brain stem response testing. Int J Pediatr Otorhinolaryngol, 2005. 69(11): p. 1541-5.
  • 10. Frey K.,Sukhani R., Pawlowski J., Pappas A.L., Mikat-Stevens M., Slogoff S.Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedationquality, intraocular pressure changes, and recovery profiles. AnesthAnalg, 1999. 89(2): p. 317-21.
  • 11. Slavik, V.C. and P.J. Zed, Combination ketamine and propofol for procedural sedation and analgesia. Pharmacotherapy, 2007. 27(11): p. 1588-98.
  • 12. David, H. and J. Shipp, A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. Ann Emerg Med, 2011. 57(5): p. 435-41.
  • 13. Dereli N, Babayiğit M, and Horasanı E. The comparison of the efficacy of different sedation protocols in colonoscopy. Gülhane Tıp Derg 2016. 58: p. 3-147.
  • 14. Khajavi M.,Emami A., Etezadi F., Safari, S.Sharifi A., ShariatMoharari R.ConsciousSedationandAnalgesia in Colonoscopy: Ketamine/Propofol Combination has SuperiorPatientSatisfactionVersusFentanyl/Propofol.AnesthPainMed, 2013. 3(1): p. 208-13.
  • 15. Aydogmus, M.T.,Turk, H. S., Oba S., Gokalp, O.A comparison of differentproportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy. Arch Med Sci, 2015. 11(3): p. 570-6.
  • 16. Green, S.M., G. Andolfatto, and B. Krauss, Ketofol for procedural sedation? Pro and con. Ann Emerg Med, 2011. 57(5): p. 444-8.
  • 17. Miner J.R.,Moore J.C., Austad E.J., Plummer D., Hubbard L., Gray R.O. Randomized, double-blinded, clinicaltrial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department. Ann Emerg Med, 2015. 65(5): p. 479-488 e2.
  • 18. Badrinath S.,Avramov M.N., Shadrick M., Witt, T. R., Ivankovich, A. D.Theuse of a ketamine-propofol combination during monitored anesthesia care. Anesth Analg, 2000. 90(4): p. 858-62.
  • 19. Kwok R.F.,Lim, J., Chan M.T., Gin T., Chiu W. K. Preoperative ketamine improves post operative analgesi aafter gynecologic laparoscopic surgery. Anesth Analg, 2004. 98(4): p. 1044-9,
  • 20. Messenger D.W.,Murray H.E., Dungey P.E., Van Vlymen J., Sivilotti M. L. Subdissociative-dose ketamine versus fentanyl for analgesia during propofol procedural sedation: a randomized clinical trial .Acad Emerg Med, 2008. 15(10): p. 877-86.
  • 21. Friedberg, B.L., Propofol-ketamine technique. Aesthetic Plast Surg, 1993. 17(4): p. 297-300.
  • 22. Loh, G. and D. Dalen, Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department. Ann Pharmacother, 2007. 41(3): p. 485-92.
  • 23. Aouad, M.T.Moussa, A. R.Dagher, C. M, et al.,Addition of ketamine to propofol for initiation of procedural anesthesia in children reduces propofol consumption and preserves hemodynamic stability. Acta Anaesthesiol Scand, 2008. 52(4): p. 561-5.

A comparison of propofol with ketofol for sedation quality and side effects in patients undergoing colonoscopy.

Year 2021, Volume: 38 Issue: 2s, 65 - 70, 18.03.2021

Abstract

Colonoscopy is an endoscopic method and ıt is better to perform this procedure under sedoanalgesia in order to eliminate patients’ anxiety, the colic-like pain and discomfort that occur during the procedure [1].
The aim of this study was to compare the effects of propofol and propofol+ketamine (ketofol) on sedation and side effects in patients undergoing colonoscopy.
Material-Method: 50 patients with ASA I-II that are between the ages of 18-65. The patients in the propofol group and Ketofol group were given 0.1mL/kg of drug and/or combination of drugs. The vital parameters, injection pain, spontaneous time of opening eyes, the time of Modified Aldrete Score (MAS) ≥ 9 and the amount of medication used during the procedure and in the recovery room were recorded.
Results: There was no significant difference between the two groups during the procedure and in the recovery room (p<0.05). It was shown that the ketamine reduces the amount of propofol by 50% and propofol induced injection pain. Ketofol had no positive effects on hemodynamic and respiratory parameters.
Conclusion: We assert that the ratio of combinations will vary depending on the necessary sedation level and analgesic need of the procedure to be performed and depending on the frequency of the administration of additional doses. Although ketofol is being used in different procedures and different age groups in the recent years, there is still need for studies conducted with different drug dosages of this combination.

Project Number

OMU KAEK 2013/301 ETİK KURUL İZİNİ İLE ÇALIŞMA YAPILMIŞTIR.

References

  • References 1. Seip B.,Bretthauer M., Dahler S.Patient satisfaction with on-demand sedation for out patient colonoscopy. Endoscopy, 2010. 42(8): p. 639-46.
  • 2. Akcaboy, Z.N.,Akcaboy, E. Y.Albayrak, D.Altinoren, B.Dikmen, B.Gogus, N.Can remifentanil be a better choice than propofol for colonoscopy during monitored anesthesia care?Acta Anaesthesiol Scand, 2006. 50(6): p. 736-41.
  • 3. Mourad M, El-Hamamsy M, and Anwar M, Low dose ketamine reduces sedative doses of propofol during ambulatory transoesophageal echocardiography. Egypt J Anaesth 2004. 20: p. 41–46.
  • 4. Willman, E.V. and G. Andolfatto, A prospective evaluation of "ketofol" (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department. Ann Emerg Med, 2007. 49(1): p. 23-30.
  • 5. Andolfatto, G. and E. Willman, A prospective case series of single-syringe ketamine-propofol (Ketofol) for emergency department procedural sedation and analgesia in adults. Acad Emerg Med, 2011. 18(3): p. 237-45.
  • 6. Shah A.,Mosdossy G., McLeod S., Lehnhardt K., Peddle M., Rieder M.A blinded, randomized controlled trial to evaluate ketamine/propofol versus ketamine alone for procedural sedation in children.AnnEmergMed, 2011. 57(5): p. 425-33 e2.
  • 7. Andolfatto, G. and E. Willman, A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol). Acad Emerg Med, 2010. 17(2): p. 194-201.
  • 8. Smischney, N.J.,Beach, M. L.Loftus, R. W.Dodds, T. M.Koff, M. Ketamine /propofoladmixture (ketofol) is associated with improved hemodynamics as an inductionagent: a randomized, controlledtrial. J TraumaAcuteCareSurg, 2012. 73(1): p. 94-101.
  • 9. Akin, A.,Esmaoglu A., Tosun Z., Gulcu N., Aydogan H., Boyaci A.Comparison of propofol with propofol-ketamine combination in pediatric patients undergoing auditory brain stem response testing. Int J Pediatr Otorhinolaryngol, 2005. 69(11): p. 1541-5.
  • 10. Frey K.,Sukhani R., Pawlowski J., Pappas A.L., Mikat-Stevens M., Slogoff S.Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedationquality, intraocular pressure changes, and recovery profiles. AnesthAnalg, 1999. 89(2): p. 317-21.
  • 11. Slavik, V.C. and P.J. Zed, Combination ketamine and propofol for procedural sedation and analgesia. Pharmacotherapy, 2007. 27(11): p. 1588-98.
  • 12. David, H. and J. Shipp, A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. Ann Emerg Med, 2011. 57(5): p. 435-41.
  • 13. Dereli N, Babayiğit M, and Horasanı E. The comparison of the efficacy of different sedation protocols in colonoscopy. Gülhane Tıp Derg 2016. 58: p. 3-147.
  • 14. Khajavi M.,Emami A., Etezadi F., Safari, S.Sharifi A., ShariatMoharari R.ConsciousSedationandAnalgesia in Colonoscopy: Ketamine/Propofol Combination has SuperiorPatientSatisfactionVersusFentanyl/Propofol.AnesthPainMed, 2013. 3(1): p. 208-13.
  • 15. Aydogmus, M.T.,Turk, H. S., Oba S., Gokalp, O.A comparison of differentproportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy. Arch Med Sci, 2015. 11(3): p. 570-6.
  • 16. Green, S.M., G. Andolfatto, and B. Krauss, Ketofol for procedural sedation? Pro and con. Ann Emerg Med, 2011. 57(5): p. 444-8.
  • 17. Miner J.R.,Moore J.C., Austad E.J., Plummer D., Hubbard L., Gray R.O. Randomized, double-blinded, clinicaltrial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department. Ann Emerg Med, 2015. 65(5): p. 479-488 e2.
  • 18. Badrinath S.,Avramov M.N., Shadrick M., Witt, T. R., Ivankovich, A. D.Theuse of a ketamine-propofol combination during monitored anesthesia care. Anesth Analg, 2000. 90(4): p. 858-62.
  • 19. Kwok R.F.,Lim, J., Chan M.T., Gin T., Chiu W. K. Preoperative ketamine improves post operative analgesi aafter gynecologic laparoscopic surgery. Anesth Analg, 2004. 98(4): p. 1044-9,
  • 20. Messenger D.W.,Murray H.E., Dungey P.E., Van Vlymen J., Sivilotti M. L. Subdissociative-dose ketamine versus fentanyl for analgesia during propofol procedural sedation: a randomized clinical trial .Acad Emerg Med, 2008. 15(10): p. 877-86.
  • 21. Friedberg, B.L., Propofol-ketamine technique. Aesthetic Plast Surg, 1993. 17(4): p. 297-300.
  • 22. Loh, G. and D. Dalen, Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department. Ann Pharmacother, 2007. 41(3): p. 485-92.
  • 23. Aouad, M.T.Moussa, A. R.Dagher, C. M, et al.,Addition of ketamine to propofol for initiation of procedural anesthesia in children reduces propofol consumption and preserves hemodynamic stability. Acta Anaesthesiol Scand, 2008. 52(4): p. 561-5.
There are 23 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Ender Çam 0000-0002-5271-4692

Deniz Karakaya This is me

Sibel Baris

Project Number OMU KAEK 2013/301 ETİK KURUL İZİNİ İLE ÇALIŞMA YAPILMIŞTIR.
Publication Date March 18, 2021
Submission Date August 19, 2020
Acceptance Date January 2, 2021
Published in Issue Year 2021 Volume: 38 Issue: 2s

Cite

APA Çam, E., Karakaya, D., & Baris, S. (2021). A comparison of propofol with ketofol for sedation quality and side effects in patients undergoing colonoscopy. Journal of Experimental and Clinical Medicine, 38(2s), 65-70.
AMA Çam E, Karakaya D, Baris S. A comparison of propofol with ketofol for sedation quality and side effects in patients undergoing colonoscopy. J. Exp. Clin. Med. March 2021;38(2s):65-70.
Chicago Çam, Ender, Deniz Karakaya, and Sibel Baris. “A Comparison of Propofol With Ketofol for Sedation Quality and Side Effects in Patients Undergoing Colonoscopy”. Journal of Experimental and Clinical Medicine 38, no. 2s (March 2021): 65-70.
EndNote Çam E, Karakaya D, Baris S (March 1, 2021) A comparison of propofol with ketofol for sedation quality and side effects in patients undergoing colonoscopy. Journal of Experimental and Clinical Medicine 38 2s 65–70.
IEEE E. Çam, D. Karakaya, and S. Baris, “A comparison of propofol with ketofol for sedation quality and side effects in patients undergoing colonoscopy”., J. Exp. Clin. Med., vol. 38, no. 2s, pp. 65–70, 2021.
ISNAD Çam, Ender et al. “A Comparison of Propofol With Ketofol for Sedation Quality and Side Effects in Patients Undergoing Colonoscopy”. Journal of Experimental and Clinical Medicine 38/2s (March 2021), 65-70.
JAMA Çam E, Karakaya D, Baris S. A comparison of propofol with ketofol for sedation quality and side effects in patients undergoing colonoscopy. J. Exp. Clin. Med. 2021;38:65–70.
MLA Çam, Ender et al. “A Comparison of Propofol With Ketofol for Sedation Quality and Side Effects in Patients Undergoing Colonoscopy”. Journal of Experimental and Clinical Medicine, vol. 38, no. 2s, 2021, pp. 65-70.
Vancouver Çam E, Karakaya D, Baris S. A comparison of propofol with ketofol for sedation quality and side effects in patients undergoing colonoscopy. J. Exp. Clin. Med. 2021;38(2s):65-70.