The effect of chamomile on nausea and vomiting after laparoscopic cholecystectomy: A triple-blind randomized clinical trial

Year 2023, Volume: 40 Issue: 1, 31 - 36, 18.03.2023

Soheila Bakhtiari Gholamreza Khalili Razieh Salimi Zadak

Abstract

The present study aimed to evaluate the effect of Chamomilla Recutita on nausea and vomiting after laparoscopic cholecystectomy. Chamomilla Recutita (L.) fell into either chamomile or placebo groups randomly. The intervention was performed one hour before the operation. The severity of nausea and the frequency of vomiting was measured using a visual analog scale. Both groups were studied in three stages before the operation, after the operation in recovery, and 2 hours after the operation. Data were analyzed using descriptive and analytical statistics (SPSS). The mean severity of nausea increased significantly over time in both groups; however, this increase was significantly slighter in the chamomile group than that in the placebo group. The frequency of preoperative nausea in the chamomile and placebo groups was 6.2% and 25%, respectively, before being discharged from the recovery. Two hours later, in the surgical ward, this frequency was estimated to be 31.2% in the chamomile group and 75% in the placebo group (P <0.05). The frequency of vomiting in the surgical ward was 15.6% and 56.2% in the chamomile and placebo groups, respectively. Thus, this frequency in the chamomile group was significantly lower than in the placebo group (P<0.001). It seems that in laparoscopic surgeries, the use of chamomile drops as a preventive drug reduces postoperative nausea and vomiting.

Keywords

Chamomilla Recutita (species: M. chamomilla), Nausea, Vomiting, Laparoscopy, Cholecystectomy.

References

• 1. Amirshahi M, Behnamfar N, Badakhsh M, Rafiemanesh H, Keikhaie KR, Sheyback M, et al. Prevalence of postoperative nausea and vomiting: A systematic review and meta-analysis. Saudi journal of anaesthesia. 2020;14(1):48.
• 2. Eslami J, Darvishi I, Ebrahimi A, Akbarzadeh M. Effect of acupressure in Pericardium 6 acupoint on nausea and vomiting after general surgery. Nursing and Midwifery Studies. 2019;8(3):143-8.
• 3. Gan TJ, Belani KG, Bergese S, Chung F, Diemunsch P, Habib AS, et al. Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesthesia & Analgesia. 2019;131(2):411-48.
• 4. Lee H-M, Kil HK, Koo BN, Song MS, Park JH. Comparison of Sufentanil-and Fentanyl-based Intravenous Patient-controlled Analgesia on Postoperative Nausea and Vomiting after Laparoscopic Nephrectomy: A Prospective, Double-blind, Randomized-controlled Trial. International journal of medical sciences. 2020;17(2):207.
• 5. Turgut HC, Arslan M. An overview of treatment options for postoperative nausea and vomiting after laparoscopic surgical procedures. Anaesthesia, Pain & Intensive Care. 2019:193-200.
• 6. Wanjura V. Register-based studies on cholecystectomy: Quality of life after cholecystectomy, and cholecystectomy incidence and complications after gastric bypass: Örebro University; 2017.
• 7. O’Rourke N, van Rensburg A. Post Cholecystectomy Symptoms. The Management of Gallstone Disease: Springer; 2018.
• 8. Hines S, Steels E, Chang A, Gibbons K. Aromatherapy for treatment of postoperative nausea and vomiting. Cochrane Database of Systematic Reviews. 2018(3).
• 9. Shahinfar J, ZERAATI H, VAFAEI S, HASHEMI F, GHORBANZADEH M. Compare adequate intraoperative fluid therapy with Ondansetron on the incidence and severity of nausea and vomiting after general surgery. 2016.
• 10. Hosseini FS, Adib-Hajbaghery M. Ginger essence effect on nausea and vomiting after open and laparoscopic nephrectomies. Nursing and midwifery studies. 2015;4(2).
• 11. Ebrahimi SM, Parsa-Yekta Z, Nikbakht-Nasrabadi A, Hosseini SM, Sedighi S, Salehi-Surmaghi M-H. Ginger effects on control of chemotherapy induced nausea and vomiting. Tehran University Medical Journal. 2013;71(6).
• 12. Modarres M, Mirmohhamad AM, Oshrieh Z, Mehran A. Comparison of the effect of mefenamic acid and matricaria camomilla capsules on primary dysmenorrhea. 2011.
• 13. Mortajia Z, Emaratkar E, Jodeiric B, Jafarid F. Assessment of reasons and treatment of bloating from the perspective of traditional Iranian medicine. Journal of Islamic and Iranian Traditional Medicine. 2018;8(4):415-22.
• 14. Darvishpor S, Hosseini A, Davoodi A, Salehifar E, Akbari J, Azadbakht M. A review on medicinal plants used for nausea and vomiting in Persian medicine. Global Journal of Medical Research: B Pharma, Drug Discovery, Toxicology & Medicine. 2018;18(1):30-40.
• 15. Bahrani SS, Varkaneh ZK, Sabziani Z, Bagheri Z, Mohamadi MA, Azami H. A Systematic Review of the Role of Medicinal Plants in the Treatment of Chemotherapy Induced Nausea and Vomiting. International Journal of Psychosocial Rehabilitation. 2020;24(4):7888-96.
• 16. Rabiei Z, Rafieian M. A review on the pharmacological effects of Matricaria chamomilla. Iranian Journal of Physiology and Pharmacology. 2019;2(4):248-0.
• 17. Chauhan ES, Jaya A. Chamomile an Ancient Aromatic Plant-A Review. Journal of Ayurveda Medical Sciences. 2017;2(4).
• 18. Albrecht U, Müller V, Schneider B, Stange R. Efficacy and safety of a herbal medicinal product containing myrrh, chamomile and coffee charcoal for the treatment of gastrointestinal disorders: a non-interventional study. BMJ open gastroenterology. 2014;1(1).
• 19. Sanaati F, Najafi S, Kashaninia Z, Sadeghi M. Effect of ginger and chamomile on nausea and vomiting caused by chemotherapy in Iranian women with breast cancer. Asian Pacific Journal of Cancer Prevention. 2016;17(8):4125-9.
• 20. Sharafzadeh S, Alizadeh O. German and Roman chamomile. Journal of applied pharmaceutical science. 2011;1(10):01-5.
• 21. Molavi Vardanjnai M, Sasani L. Effects of Matricaria Chamomilla on the Severity of Nausea and Vomiting Due to Chemotherapy. Avicenna Journal of Nursing and Midwifery Care. 2017;25(4):140-6.
• 22. Pakniat H, Memarzadeh MR, Azh N, Mafi M, Ranjkesh F. Comparison of the effect of chamomile, Ginger and vitamin B6 on treatment of nausea and vomiting in pregnancy: a randomized clinical trial. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2018;21(8):47-54.
• 23. Zargaran A, Borhani-Haghighi A, Salehi-Marzijarani M, Faridi P, Daneshamouz S, Azadi A, et al. Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study. Neurological Sciences. 2018;39(8):1345-53.
• 24. Johnson ES, Hylands PJ, nee Jessup DMH. Oil extract of tanacetum parthenium for treating migraine. Google Patents; 1988.
• 25. Putri IN, Amelia R, Rahayu S. The chamomile aromatherapy reduce the scale of nausea. International Journal of Public Health Science. 2019;8(3):294-9.
• 26. Hannani S, Arbkhazaie A, Sadati L, Arbkhazaie A. Determining operating room technologists' clinical competence in educational care hospitals of Iran University of Medical Sciences in the year is 2017. Journal of Advanced Pharmacy Education & Research| Apr-Jun. 2019;9(S2):71.
• 27. Montazeri A, Raei M, Hamidzadeh A, Hamzekhani M, Soozani A, Kalatejari M. effect of ginger on postoperative nausea and vomiting. . Knowledge and Health. 2012;7(3):118-23.
• 28. Tavasoli A, KHAJE DM, Alipour M, Bigdeli N. Comparison of ondansetron and the combination of dexametasone-metocholopromide on post operative nausea and vomiting. 2011.
• 29. Matthews A, Haas DM, O'Mathúna DP, Dowswell T. Interventions for nausea and vomiting in early pregnancy. Cochrane Database of Systematic Reviews. 2015(9).