Evaluation of patients admitted to the emergency department after Coronavac (Sinovac) vaccination?

Year 2023, Volume: 40 Issue: 1, 80 - 84, 18.03.2023

Bahadir Taslidere Ertan Sönmez Serdar Özdemir

Abstract

To evaluate the symptoms and laboratory parameters of patients admitted to the emergency department after CoronaVac (Sinovac) vaccination. Complaints, demographic characteristics, laboratory tests, interventions, and outcomes of patients admitted to the emergency department within seven days of receiving the CoronaVac (Sinovac) were all evaluated. Pain at the injection site, swelling, redness, and pain in the injected arm were expected side effects of the vaccination. In this study, a total of six people had syncope following the vaccination, one of whom developed an allergic reaction. The most common adverse events in non-geriatrics were fatigue, headache, fever, and abdominal pain, while in geriatric patients’ fatigue, headache, chest pain, and dyspnea were most common, with fever falling in the last place. Rare symptoms following vaccination included syncope and urticaria. It is necessary to be prepared for the side effects that may occur during mass vaccination against COVID-19. In this study, the body’s response to the vaccine in geriatric patients was atypical in vital signs and laboratory values.

Keywords

Emergency department, SARS-CoV-2, COVID-19, vaccine, side effect

References

• Canoui E, Launay O. History and principles of vaccination. Rev Mal Respir. 2019;36(1):74-81
• Saatçi E, Şen SK, Öztürk YK. The COVID-19 Pandemic and Health Workers. Türk Aile Hek Derg. 2020;24:172-4
• Yen JS, Wang IK, Yen TH. COVID-19 vaccination and dialysis patients: why the variable response. QJM. 2021 Nov 5;114(7):440-444.
• Dhillon P, Altmann D, Male V. COVID-19 vaccines: what do we know so far? FEBS J. 2021 Sep;288(17):4996-5009.
• Xia S, Zhang Y, Wang Y, Wang H, Yang Y, Gao GF, et al. Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebocontrolled, phase 1/2 trial. Lancet Infect Dis. 2020;21:39–51
• Kahraman EP, Altındis M. COVID-19 Aşıları; Pandemide Sona Doğru? J Biotechnol and Strategic Health Res. 2020;4:240-9
• Rossen LM, Branum AM, Ahmad FB, Sutton P, Anderson RN. Excess deaths associated with COVID-19, by age and race and ethnicity—United States, January 26–October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1522–7
• Bsoul EA, Loomer PM. COVID-19 vaccination experience among United States dental professionals and students: Safety, confidence, concerns, and side effects. PLoS One. 2022 Feb 22;17(2):e0264323.
• Djanas D, Martini RD, Putra H, Zanir A, Nindrea RD. Survey Data of COVID-19 Vaccine Side Effects among Hospital Staff in a National Referral Hospital in Indonesia. Data Br. 2021;36,107098
• Guimaraes LE, Baker B, Perricone C, Shoenfeld Y. Vaccines, adjuvants and autoimmunity. Pharmacol Res. 2015;100:190-209
• Nittner-Marszalska M, Rosiek-Biegus M, Kopec A, Pawlowicz R, Kosinska M. Pfizer-BioNTech COVID-19 Vaccine Tolerance in Allergic versus Non-Allergic Individuals. Vaccines (Basel). 2021;9(6):553.
• McNeil MM, DeStefano F. Vaccine-associated hypersensitivity. J Allergy. Clin Immunol. 2018;141:463–72.
• Bellomo RG, Gallenga CE, Caraffa A, Tete G, Ronconi G, Conti P. Anaphylaxis is a rare reaction in COVID-19 vaccination. J Biol Regul Homeost Agents. 2021;35(1):1-4.
• Shimabukuro T, Nair N. Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine. JAMA. 2021;23:780-1.
• Garvey LH, Dewachter P, Hepner DL. Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations. Br J Anaesth. 2019;123:50–64.
• El Chakhtoura NG, Bonomo RA, Jump RLP. Influence of Aging and Environment on Presentation of Infection in Older Adults. Infect Dis Clin North Am. 2017;31(4):593-608.
• Spangler R, Pham TV, Khoujah D, Martinez JP. Abdominal emergencies in the geriatric patient. Int J Emerg Med. 2014;7:43.
• Meo S, Bukhari I, Akram J, Meo A, Klonoff D. COVID-19 vaccines: Comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. Eur. Rev. Med. Pharmacol. Sci. 2021;25;1663–9.
• Torjesen I. Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination. BMJ. 2021;372:149.