Investigating the role of microRNAs, inflammation, and Helicobacter pylori in Epstein-Barr virus associated gastric cancer

Amin Ebadi; Reyhaneh Rasizadeh; Parisa Shiri Aghbash; Nima Hemmat; Hossein Bannazadeh Baghi

Review

Investigating the role of microRNAs, inflammation, and Helicobacter pylori in Epstein-Barr virus associated gastric cancer

Year 2023, Volume: 40 Issue: 3, 646 - 658, 30.09.2023

Amin Ebadi Reyhaneh Rasizadeh , Parisa Shiri Aghbash , Nima Hemmat Hossein Bannazadeh Baghi

Abstract

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a distinct subtype that accounts for nearly 10% of gastric carcinomas. This type of gastric cancer has no relation to any mutation in chromosomal genes, and EBV causes cancer by affecting the epigenetics of host cells through methylation and inactivation of the promoter of tumor suppressor genes. This suggests that EBV infection precedes the clonal growth of EBV-infected cells and subsequently develops carcinoma. Chronic gastritis in the background of EBVaGC might enhance the chance of interaction between gastric epithelial cells and B lymphocytes, and cytokines produced by inflammatory cells might support the growth of EBV-infected gastric epithelial cells. Numerous modifiable risk factors have been identified for gastric cancer (GC).
Inflammation is a complicated host immune response to biological, chemical, and physical invasions. Chronic inflammation, which is caused by genetic mutations, autoimmune diseases, constant exposure to environmental factors, and viral infections, can significantly increase the risk of cancer. According to epidemiologic studies, chronic infection and inflammation are considered the main risk factors for different types of cancer. Furthermore, although oncogenic viruses stimulate inflammation by dint of different mechanisms, they generally activate certain signaling pathways, including NF-κB and STAT3, in charge of cancer development. The role of EBV in chronic gastric inflammation has received little attention. However, several studies have indicated EBV as well as Helicobacter pylori to be initially involved in the oncogenic process of gastric cancer by increasing chronic inflammation and tissue damage. Moreover, other risk factors including lifestyle and HPV infection play a role in the progress of gastric cancer.

Keywords

Epstein Barr Virus, Helicobacter Pylori, Gastric cancer, Inflammation, MicroRNA

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Year 2023, Volume: 40 Issue: 3, 646 - 658, 30.09.2023

Amin Ebadi Reyhaneh Rasizadeh , Parisa Shiri Aghbash , Nima Hemmat Hossein Bannazadeh Baghi

Abstract

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Primary Language	English
Subjects	Health Care Administration
Journal Section	Review Articles
Authors	Amin Ebadi This is me 0000-0001-9807-4080 Reyhaneh Rasizadeh 0000-0003-0734-8168 Parisa Shiri Aghbash 0000-0001-6733-4556 Nima Hemmat This is me 0000-0001-6432-9647 Hossein Bannazadeh Baghi 0000-0002-2513-5361
Early Pub Date	October 6, 2023
Publication Date	September 30, 2023
Submission Date	October 31, 2022
Acceptance Date	July 6, 2023
Published in Issue	Year 2023 Volume: 40 Issue: 3

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APA	Ebadi, A., Rasizadeh, R., Shiri Aghbash, P., Hemmat, N., et al. (2023). Investigating the role of microRNAs, inflammation, and Helicobacter pylori in Epstein-Barr virus associated gastric cancer. Journal of Experimental and Clinical Medicine, 40(3), 646-658.
AMA	Ebadi A, Rasizadeh R, Shiri Aghbash P, Hemmat N, Bannazadeh Baghi H. Investigating the role of microRNAs, inflammation, and Helicobacter pylori in Epstein-Barr virus associated gastric cancer. J. Exp. Clin. Med. September 2023;40(3):646-658.
Chicago	Ebadi, Amin, Reyhaneh Rasizadeh, Parisa Shiri Aghbash, Nima Hemmat, and Hossein Bannazadeh Baghi. “Investigating the Role of MicroRNAs, Inflammation, and Helicobacter Pylori in Epstein-Barr Virus Associated Gastric Cancer”. Journal of Experimental and Clinical Medicine 40, no. 3 (September 2023): 646-58.
EndNote	Ebadi A, Rasizadeh R, Shiri Aghbash P, Hemmat N, Bannazadeh Baghi H (September 1, 2023) Investigating the role of microRNAs, inflammation, and Helicobacter pylori in Epstein-Barr virus associated gastric cancer. Journal of Experimental and Clinical Medicine 40 3 646–658.
IEEE	A. Ebadi, R. Rasizadeh, P. Shiri Aghbash, N. Hemmat, and H. Bannazadeh Baghi, “Investigating the role of microRNAs, inflammation, and Helicobacter pylori in Epstein-Barr virus associated gastric cancer”, J. Exp. Clin. Med., vol. 40, no. 3, pp. 646–658, 2023.
ISNAD	Ebadi, Amin et al. “Investigating the Role of MicroRNAs, Inflammation, and Helicobacter Pylori in Epstein-Barr Virus Associated Gastric Cancer”. Journal of Experimental and Clinical Medicine 40/3 (September 2023), 646-658.
JAMA	Ebadi A, Rasizadeh R, Shiri Aghbash P, Hemmat N, Bannazadeh Baghi H. Investigating the role of microRNAs, inflammation, and Helicobacter pylori in Epstein-Barr virus associated gastric cancer. J. Exp. Clin. Med. 2023;40:646–658.
MLA	Ebadi, Amin et al. “Investigating the Role of MicroRNAs, Inflammation, and Helicobacter Pylori in Epstein-Barr Virus Associated Gastric Cancer”. Journal of Experimental and Clinical Medicine, vol. 40, no. 3, 2023, pp. 646-58.
Vancouver	Ebadi A, Rasizadeh R, Shiri Aghbash P, Hemmat N, Bannazadeh Baghi H. Investigating the role of microRNAs, inflammation, and Helicobacter pylori in Epstein-Barr virus associated gastric cancer. J. Exp. Clin. Med. 2023;40(3):646-58.

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